Release of Enterococcus mundtii Bacteriocin ST4SA from Self-Setting Brushite Bone Cement
Date
2011
Authors
van Staden A.D.
Heunis T.D.J.
Dicks L.M.T.
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Abstract
Maxillofacial and craniofacial surgery is on the increase, which exposes more patients at risk of acquiring microbial infections. The use of antibiotic-loaded calcium phosphate bone cements has been shown to reduce the incidence of infection. A marked increase in antibiotic-resistant pathogens, including multidrug-resistant pathogens, has been reported. This has led to the investigation of various compounds as alternatives to conventional treatments. In this paper, we report on the incorporation and release of a broad-spectrum class II antimicrobial peptide, bacteriocin ST4SA produced by Enterococcus mundtii, into a calcium orthophosphate-based bone cement. Our results suggest class II bacteriocins may be incorporated into self-setting bone cements to produce implants with antimicrobial activity over extended periods of time. © 2011 Springer Science + Business Media, LLC.
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Probiotics and Antimicrobial Proteins
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