Department of Pathology
Sub-communities within this community
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Anatomical Pathology [65]
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Chemical Pathology [87]
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Forensic Medicine [17]
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Medical Microbiology [94]
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Medical Virology [168]
Recent Submissions
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Peripheral blood lymphocyte proviral DNA predicts neurocognitive impairment in clade C HIV
(Springer, 2020-07)It is not known if proviral DNA in the periphery corresponds to cognitive status in clade C as it does in clade B and recombinant forms. A cross-sectional study was conducted on participants investigated for HIV-associated ... -
Characterisation of follicular helper T (Tfh) cells in early treated HIV-infected children: relationship to immune activation and inflammation.
(Stellenbosch : Stellenbosch University, 2022-11-24)ENGLISH ABSTRACT: Background: South Africa has a high burden of Human Immunodefiency Virus (HIV) infection. Babies of HIV-positive pregnant women can become HIV-infected or exposed through vertical transmission. Follicular ... -
The role of underdiagnosed viruses in neonatal sepsis
(Stellenbosch : Stellenbosch University, 2022-12)ENGLISH ABSTRACT: Background Neonatal sepsis is a clinical syndrome that is difficult to diagnose due to the unspecific symptoms that patients present with. Several different diagnostic techniques are used to diagnose ... -
Femicide in the Eastern Metropole of Cape Town : A 5-year retrospective analysis
(Stellenbosch : Stellenbosch University, 2022-11)ENGLISH ABSTRACT: Background: Violence against woman continues to be a global health problem with formicide being its most severe form, especially in a country with one of the world's highest homicide rates. Aim: To ... -
Comparison of commercial assays and two-step approach to detect Clostridioides difficile in South Africa
(AOSIS, 2022-09)Background: Clostridioides difficile is the number one cause of hospital-acquired diarrhoea. Accurate diagnosis of C. difficile is of utmost importance as it guides patient management and infection control practices. Studies ... -
Delays in HIV-1 infant polymerase chain reaction testing may leave children without confirmed diagnoses in the Western Cape province, South Africa
(AOSIS, 2022-06)Background: Early diagnosis and confirmation of HIV infection in newborns is crucial for expedited initiation of antiretroviral therapy. Confirmatory testing must be done for all children with a reactive HIV PCR result. ... -
Establishing Ghanaian adult reference intervals for hematological parameters controlling for latent anemia and inflammation
(Wiley, 2020-09)Background: In Ghana, diagnostic laboratories rely on reference intervals (RIs) provided by manufacturers of laboratory analyzers which may not be appropriate. This study aimed to establish RIs for hematological ... -
The association between pathogen factors and clinical outcomes in patients with Staphylococcus aureus bacteraemia in a tertiary hospital, Cape Town
(Elsevier, 2019-11)Background: Staphylococcus aureus is a serious pathogen, able to cause life-threatening infections such as bacteraemia. The association between S. aureus microbial characteristics and clinical outcomes is under-investigated ... -
Clonal expansion of colistin-resistant Acinetobacter baumannii isolates in Cape Town, South Africa
(Elsevier, 2020-02)Objectives: To describe colistin-resistant Acinetobacter baumannii isolates in Cape Town, South Africa. Methods: A. baumannii isolates identified on Vitek 2 Advanced Expert System were collected from Tygerberg Hospital ... -
Endobronchial masses encountered on fine-needle aspiration biopsy : a focus on unusual entities
(2020-04-24)Fine-needle aspiration biopsy (FNAB) is a useful technique in the evaluation of central lung tumors which is commonly encountered in clinical cytology practice. Some of these tumors may show endobronchial, polypoid growth ... -
Circulating miR-30a-5p and miR-182-5p in prediabetes and screen-detected diabetes mellitus
(Dove Press, 2020-12)Background: microRNAs (miRNAs) have been touted as potential diagnostic and prognostic biomarkers for various diseases. The aim of the present study was to evaluate the diagnostic value of miR-30a-5p and miR-182-5p for ... -
Effusion cytology of a mucinous borderline ovarian tumour : Pitfall or controversy? a case report with insight into the newly proposed international system for reporting serous fluid cytology
(WileyBritish Society for Clinical Cytology, 2021-11)A case report of effusion cytology of a mucinous neoplasm is illustrated. The authors share their insight into adapting the newly proposed international system for reporting serous fluid cytology. -
Drug resistance mutations against protease, reverse transcriptase and integrase inhibitors in people living with HIV-1 receiving boosted protease inhibitors in South Africa
(Frontiers Media, 2020-03)The South African national combination antiretroviral therapy (cART) roll-out program started in 2006, with over 4.4 million people accessing treatment since it was first introduced. HIV-1 drug resistance can hamper the ... -
Molecules in pathogenesis: angiotensin converting enzyme 2 (ACE2)
(BMJ Publishing Group Ltd & Association of Clinical Pathologists, 2021-04)The renin–angiotensin system is mainly associated with the regulation of blood pressure, but recently many other functions of this system have been described. ACE2, an 805-amino acid monocarboxypeptidase type I transmembrane ... -
Assessment of the association of plant- based diets with cardiovascular disease risk profile in Africa: a systematic review and meta-analysis protocol
(BMJ Publishing, 2020-06)Introduction Cardiovascular disease (CVD) is currently the leading cause of death worldwide. In Africa where infectious diseases are still the leading cause of death, the contribution of non-communicable diseases led by ... -
A method comparison study of a point-of-care blood gas analyser with a laboratory auto-analyser for the determination of potassium concentrations during hyperkalaemia in patients with kidney disease
(2020-07)Introduction: Hyperkalaemia is a common electrolyte disorder that may cause life-threatening cardiac arrythmias. We aimed to determine the agreement of potassium concentrations between GEM premier 3500 point-of-care blood ... -
Postmortem lung biopsies from four patients with COVID-19 at a tertiary hospital in Cape Town, South Africa
(Health & Medical Publishing Group, 2020-10-19)Background. An outbreak of a novel coronavirus in China in late 2019 has resulted in a global pandemic. The virus (SARS-CoV-2) causes a severe acute respiratory syndrome and had been responsible for >14 000 deaths in South ... -
Bimodal distribution and set point HBV DNA viral loads in chronic infection : retrospective analysis of cohorts from the UK and South Africa
(Wellcome Open Research, 2020-10-14)ENGLISH ABSTRACT: Hepatitis B virus (HBV) viral load (VL) is used as a biomarker to assess risk of disease progression, and to determine eligibility for treatment. While there is a well recognised association between VL ... -
Structural comparison of diverse HIV-1 subtypes using molecular modelling and docking analyses of integrase inhibitors
(MDPI, 2020-08-26)ENGLISH ABSTRACT: The process of viral integration into the host genome is an essential step of the HIV-1 life cycle. The viral integrase (IN) enzyme catalyzes integration. IN is an ideal therapeutic enzyme targeted by ... -
Responding to the Challenge of the Dual COVID-19 and Ebola Epidemics in the Democratic Republic of Congo—Priorities for Achieving Control
(2020)Abstract. As of June 11, 2020, the Democratic Republic of the Congo (DRC) has reported 4,258 COVID-19 cases with 90 deaths. With other African countries, the DRC faces the challenge of striking a balance between easing ...
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