Background: Population-based data on the burden of chronic kidney disease (CKD) in sub-Saharan Africa
is still very limited. We assessed the prevalence and determinants of CKD, and evaluated the
concordance of commonly ...
Kotze, Maritha J.Van Rensburg, Susan J.(SpringerLink, 2012-04)
Chronic, multi-factorial conditions caused by a
complex interaction between genetic and environmental risk
factors frequently share common disease mechanisms, as
evidenced by an overlap between genetic risk factors ...
Petersen, Desiree C.Libiger, OndrejTindall, Elizabeth A.Hardie, Rae-AnneHannick, Linda I.Glashoff, Richard H.Mukerji, MitaliIndian Genome Variation ConsortiumFernandez, PedroHaacke, WilfridSchork, Nicholas J.Hayes, Vanessa M.(PLOS, 2013-03)
Within-population genetic diversity is greatest within Africa, while between-population genetic diversity is directly
proportional to geographic distance. The most divergent contemporary human populations include the ...
The diversity of HIV-1 sequences derived from patients in Bushbuckridge, Mpumalanga, was investigated. The gag p24, pol p10 and p66/p51, pol p31 and env gp41 gene fragments from 51 patients were amplified and sequenced. ...
The efficiency in which HIV-1 can infect, spread and evade the attack of therapeutic
agents can be attributed to a high mutation rate and frequent recombination events.
These factors have collectively contributed to the ...
Background: Sub-Saharan Africa is the world’s worst HIV-AIDS affected region. More interventions to manage this
pandemic are urgently required. Transmission of the virus through an exchange of saliva is rarely known to ...
ENGLISH ABSTRACT: Despite the availability of Hepatitis B virus (HBV) vaccination for over three decades, this infection remains a major public health problem. Whilst the WHO recommends giving a birth dose of the vaccine, ...
ENGLISH ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the world. The disease spectrum of NAFLD extends from steatosis (types 1,2) to non-alcoholic steatohepatitis (NASH) ...
ENGLISH ABSTRACT: The purpose of this study was to investigate the association of the selected MYH9 single nucleotide polymorphisms (SNPs) with chronic kidney disease (CKD) and its related co-morbidities in the South African ...
ENGLISH ABSTRACT: Infection is a major cause of morbidity and mortality in infants within the first few months of life. Susceptibility to infectious disease in this vulnerable population is more prevalent in resource-limited ...
ENGLISH ABSTRACT: Introduction
Acute respiratory tract infections cause significant morbidity and mortality worldwide, and are
the main reason for the utilisation of health care services. Identifying the aetiological ...
ENGLISH ABSTRACT: Background/Aims: Obesity has increased rapidly in South African children and adolescents with
significant variability observed among racial groups. Genes that regulate appetite have been studied in
different ...
Background: HbA1c has been the gold standard for glycaemic control follow-up for decades. In 2009, a level of 6.5%
(48 mmol/mol) was proposed as diagnostic for diabetes. We test this cut-off in our community.
Methods: ...
ENGLISH ABSTRACT: Introduction: Flow cytometry has progressively replaced many traditional laboratory
tests due to its greater accuracy, sensitivity and rapidity in the routine clinical settings
especially clinical trails. ...
ENGLISH ABSTRACT: The aim of this study was to investigate the effect of MBV and Coley’s Toxin on dendritic
cells in vitro. The dendritic cell system of antigen presenting cells is the initiator and
modulator of the ...