• Risk factors for infection and disease in child contacts of multidrug-resistant tuberculosis : a cross-sectional study 

  Seddon, James A.   Hesseling, Anneke C.   Godfrey-Faussett, Peter   Fielding, Katherine   Schaaf, H. S. (BioMed Central, 2013-08)

  Background: Young children exposed to Mycobacterium tuberculosis have a high risk of disease progression following infection. This study aimed to determine risk factors for M. tuberculosis infection and disease in children ...
• The prevalence of symptoms associated with pulmonary tuberculosis in randomly selected children from a high burden community 

  Marais, B. J.   Obihara, C. C.   Gie, R. P.   Schaaf, H. S.   Hesseling, A. C.   Lombard, C.   Enarson, D.   Bateman, E.   Beyers, N. (BMJ Publishing Group, 2005-11)

  Background: Diagnosis of childhood tuberculosis is problematic and symptom based diagnostic approaches are often promoted in high burden settings. This study aimed (i) to document the prevalence of symptoms associated ...
• Exercise-induced asthma (EIA) -- Pathogenesis 

  Kling, Sharon (Health and Medical Publishing Group (HMPG), 2008-04)

  Exercise-induced asthma (EIA) is defined as ‘the condition in which exercise induces symptoms of asthma in patients who have asthma’.1 The question is whether EIA is a distinct phenotype of asthma or whether it is ...
• The characteristics of juvenile myasthenia gravis among South Africans 

  Heckmann, J. M.   Hansen, P.   Van Toorn, R.   Lubbe, E.   Janse Van Rensburg, E.   Wilmshurst, J. M. (Health and Medical Publishing Group (HMPG), 2012-06)

  Objectives. To report the characteristics of juvenile-onset (<20 years) myasthenia gravis (MG) in Africa. Subjects and methods. Six South African centres collected data which included acetylcholine receptor-antibody ...
• Incorrectly diagnosing children as HIV-infected : experiences from a large paediatric antiretroviral therapy site in South Africa 

  Feucht, Ute Dagmar   Thomas, Ute Dagmar   Forsyth, Brian William Cameron   Kruger, Mariana (Health and Medical Publishing Group (HMPG), 2012-08)

  Objective. To assess the extent to which children may be falsely diagnosed as HIV-infected, using data from an antiretroviral therapy (ART) site in Pretoria, South Africa. Methods. This was a retrospective patient record ...
• Aminoglycoside-induced hearing loss in HIV-positive and HIV-negtive multidrug-resistant tuberculosis patients 

  Harris, Tashneem   Bardien, Soraya   Schaaf, H. Simon   Petersen, Lucretia   De Jong, Greetje   Fagan, Johannes J. (Health and Medical Publishing Group (HMPG), 2012-06)

  Background. Ototoxicity following aminoglycoside treatment for multidrug-resistant tuberculosis (MDR-TB), is a significant problem. This study documents the incidence of ototoxicity in HIVpositive and HIV-negative ...
• Effect of Ascaris Lumbricoides specific IgE on tuberculin skin test responses in children in a high-burdensetting : a cross-sectional community-based study 

  Van Soelen, Nelda   Mandalakas, Anna M.   Kirchner, H. L.   Walzl, Gerhard   Grewal, Harleen M. S.   Jacobsen, Marc   Hesseling, Anneke C. (BioMed Central, 2012-09)

  ABSTRACT:M.tuberculosis (M.tb) is associated with enhanced T helper cell type 1 (Th1) immune responses while helminth infection is associated with T helper cell type 2 (Th2) immune responses. Our aim was to investigate ...
• Juvenile idiopathic arthritis in two tertiary centres in the Western Cape, South Africa 

  Weakley, Kate   Esser, Monika   Scott, Christiaan (BioMed Central, 2012-10)

  BACKGROUND: Juvenile idiopathic arthritis (JIA) is a disease that shows wide variations between differing populations. Since the recent international consensus on classification criteria, JIA has been widely described ...
• Paradoxical helminthiasis and giardiasis in Cape Town, South africa : epidemiology and control 

  Adams, Vera J.   Markus, Miles B.   Adams, Joanita F. A.   Jordaan, Esme   Curtis, Bronwyn   Dhansay, Muhammad A.   Obihara, Charlie C.   Fincham, John E. (Makerere University Medical School, 2005-06)

  Background. South Africa has endorsed a World Health Assembly (WHA) resolution calling for control of soil-transmitted helminths (STHs). In Cape Town, services and housing that exist in old-established suburbs should ...
• The effect of a peptide-containing synthetic lung surfactant on gas exchange and lung mechanics in a rabbit model of surfactant depletion 

  Van Zyl, Johann M.   Smith, Johan   Hawtrey, Arthur (Dovepress, 2013-03)

  Background: Currently, a new generation of synthetic pulmonary surfactants is being developed that may eventually replace animal-derived surfactants used in the treatment of respiratory distress syndrome. Enlightened by ...
• Swallowing abnormalities in HIV infected children : an important cause of morbidity 

  Nel, Etienne D.   Ellis, Alida (BioMed Central, 2012-06)

  Background: Swallowing disorders, well recognised in adults, contribute to HIV-infection morbidity. Little data however is available for HIV-infected children. The purpose of this study is to describe swallowing disorders ...
• High prevalence of lipoatrophy in pre-pubertal South African children on antiretroviral therapy : a cross-sectional study 

  Innes, Steve   Cotton, Mark F.   Haubrich, Richard   Conradie, Maria M.   Van Niekerk, Margaret   Edson, Clair   Rabie, Helena   Jain, Sonia   Sun, Xiaoying   Zollner, Ekkehard W.   Hough, Stephen   Browne, Sara H. (BioMed Central, 2012-11)

  Background: Despite changes in WHO guidelines, stavudine is still used extensively for treatment of pediatric HIV in the developing world. Lipoatrophy in sub-Saharan African children can be stigmatizing and have far-reaching ...
• High prevalence of Tuberculosis and insufficient case detection in two communities in the Western Cape, South Africa 

  Claassens, Mareli   Van Schalkwyk, Cari   De Haan, Leonie   Floyd, Sian   Dunbar, Rory   Van Helden, Paul   Godfrey-Faussett, Peter   Ayles, Helen   Borgdorff, Martien   Enarson, Donald   Beyers, Nulda (PLoS ONE, 2013-04)

  Background: In South Africa the estimated incidence of all forms of tuberculosis (TB) for 2008 was 960/100000. It was reported that all South Africans lived in districts with Directly Observed Therapy, Short-course. However, ...
• Bacterial disease and antimicrobial susceptibility patterns in HIV-Infected, hospitalized children: A retrospective cohort study 

  Jaspan, Heather B.   Huang, Lyen C.   Cotton, Mark F.   Whitelaw, Andrew   Myer, Landon (PLOS, 2008-09-24)

  Background: Serious bacterial infections are a major source of morbidity and mortality in HIV-infected children. The spectrum of disease is wide, and responsible organisms vary according to setting. The use of antibiotic ...
• Development and implementation of a national programme for the management of severe and very severe pneumonia in children in Malawi 

  Enarson, Penelope Marjorie   Gie, Robert   Enarson, Donald A.   Mwansambo, Charles (Public Library of Science -- PLOS, 2009-11)

  The reduction of child mortality by two-thirds from its 1990 level by 2015—the fourth United Nations Millennium Development Goal—is a major challenge. Pneumonia accounts for much (≥20%) of this mortality in poor countries, ...
• Lipoatrophy in HIV-infected children on antiretroviral therapy 

  Innes, Steven Eugene Vere (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: Introduction: Lipoatrophy is a common adverse effect of stavudine and this effect is strongly dose-dependent. Stavudine remains the most commonly used paediatric antiretroviral drug in sub-Saharan Africa, ...
• Eating patterns of Indian preschool children between 1-5 years of age in Howick West (Kwa-Zulu Natal) 

  Bux, Fathima (Stellenbosch : Stellenbosch University, 2003-12)

  ENGLISH ABSTRACT: Most of the risk factors for coronary heart disease (CHD) such as hypertension, dyslipidaemia, smoking, non-insulin dependent diabetes mellitus (NIDDM), obesity, physical inactivity and heredity are ...
• The epidemiology and management of drug-resistant tuberculosis in childhood 

  Schaaf, Hendrik Simon (Stellenbosch : Stellenbosch University, 2002-12)

  ENGLISH ABSTRACT: Resistance to antituberculosis agents became evident soon after antituberculosis treatment was introduced for the first time. Combined drug therapy seemed to resolve this problem. Animal experimental ...
• The influence of age on the cellular immune response in patients with tuberculosis and healthy controls 

  Schölvinck, Elisabeth Henriëtte (Stellenbosch : Stellenbosch University, 2002)

  ENGLISH ABSTRACT: Children and adults may differ in their immune function. An adequate function of the individual's immune system is crucial to the risk for development of tuberculosis (TB) after infection with Mycobacterium ...
• A comparison of synthetic surfactants : evaluation of a novel surfactant (1,2-dipalmitoyl-sn-phosphatidycholine and trehalose [C12H22O11]) and comparison with other synthetic formulations 

  Smith, Johan (Stellenbosch : Stellenbosch University, 2002-12)

  ENGLISH ABSTRACT: The aim of this study was to test a synthetic protein-free surfactant preparation, LPM-l, with the same chemical composition as commercially available Exosurf (Glaxo Wellcome), but containing in addition, ...

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