Department of Paediatrics and Child Health
Collections in this community
Recent Submissions
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Intracranial complications of Serratia marcescens infection in neonates
(Health & Medical Publishing Group, 2016)Even though Serratia marcescens is not one of the most common causes of infection in neonates, it is associated with grave morbidity and mortality. We describe the evolution of brain parenchymal affectation observed in ...
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Socioeconomic factors associated with asthma prevalence and severity among children living in low-income South African communities
(Health & Medical Publishing Group, 2016)Background. Rates of asthma, poverty and social deprivation are high among young people in South Africa (SA), yet asthma interventions largely remain focused on biomedical factors. Objective. To investigate associations ...
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Burkitt’s lymphoma patients in Northwest Cameroon have a lower incidence of sickle cell trait (Hb AS) than healthy controls
(Health & Medical Publishing Group, 2016)Contradictory findings have been reported from Africa with regard to the risk of developing Burkitt’s lymphoma (BL) in sickle cell trait (AS) carriers. Haemoglobin electrophoresis was performed in 78 BL patients in the ...
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Tuberculosis disease during pregnancy and treatment outcomes in HIV-infected and uninfected women at a referral hospital in Cape Town
(Public Library of Science, 2016)Background: Tuberculosis during pregnancy and treatment outcomes are poorly defined in high prevalence tuberculosis and HIV settings. Methods: A prospective cohort study of pregnant and postpartum women identified ...
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Low vitamin-D levels combined with PKP3-SIGIRR-TMEM16J host variants is associated with tuberculosis and death in HIV-infected and -exposed infants
(Public Library of Science, 2016)Background: This study examined the associations of 25-hydroxyvitamin D and specific host genetic variants that affect vitamin D levels or its effects on immune function, with the risk of TB or mortality in children. ...
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Pattern of infectious morbidity in HIV-exposed uninfected infants and children
(Frontiers Media, 2016)Background: Almost 30% of children in Southern Africa are HIV exposed but uninfected (HEU) and experience exposures that could increase vulnerability to infectious diseases compared to HIV unexposed (HU) children. The ...
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Optimizing research methods to understand HIV-exposed uninfected infant and child morbidity : report of the second HEU infant and child workshop
(Frontiers Media, 2016)The first HIV Exposed Uninfected (HEU) Infant and Child Workshop was held in Vancouver in July 2015, hosted by the Child and Family Research Institute at the British Columbia Children’s Hospital and University of British ...
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The association of hyperglycaemia with prevalent tuberculosis : a population-based cross-sectional study
(BioMed Central, 2016)Background: Systematic reviews suggest that the incidence of diagnosed tuberculosis is two- to- three times higher in those with diabetes mellitus than in those without. Few studies have previously reported the ...
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Cerebrospinal fluid in tuberculous meningitis exhibits only the L-enantiomer of lactic acid
(BioMed Central, 2016)Background: The defining feature of the cerebrospinal fluid (CSF) collected from infants and children with tuberculous meningitis (TBM), derived from an earlier untargeted nuclear magnetic resonance (NMR) metabolomics study, ...
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Missed opportunities of inclusion in a cohort of HIV-infected children to initiate antiretroviral treatment before the age of two in West Africa, 2011 to 2013
(International AIDS Society, 2016-03-23)Introduction: The World Health Organization (WHO) 2010 guidelines recommended to treat all HIV-infected children less than two years of age. We described the inclusion process and its correlates of HIV-infected children ...
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Informing curriculum development in health sciences
(Publisher's version, 2011)INTRODUCTION: The education of future medical professionals has to ensure that their knowledge and skills are relevant to the health care needs of their future patients, in a context of continuous change of society, science, ...
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The role of traditional healers in the diagnosis and management of Burkitt lymphoma in Cameroon : understanding the challenges and moving forward
(BioMed Central, 2017-04-11)Background Burkittlymphoma(BL) is the most common childhood cancer in Cameroon with a reported incidence of 3 per 100,000 children under 15 years in the Northwest region. Treatment at three Baptist mission hospitals has ...
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Symptom screening rules to identify active pulmonary tuberculosis : findings from the Zambian South African Tuberculosis and HIV/ AIDS Reduction (ZAMSTAR) trial prevalence surveys
(Public Library of Science, 2017-03-03)Background: High tuberculosis (TB) burden countries should consider systematic screening among adults in the general population. We identified symptom screening rules to be used in addition to cough ≥2 weeks, in a context ...
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Incomplete childhood immunization in Nigeria: a multilevel analysis of individual and contextual factors
(BioMed Central, 2017-03)ENGLISH SUMMARY : Background: Under-five mortality remains high in sub-Saharan Africa despite global decline. One quarter of these deaths are preventable through interventions such as immunization. The aim of this study ...
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Integrated management of childhood illness indicators of childhood tuberculous meningitis at a tertiary hospital in the Western Cape Province of South Africa
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT : BACKGROUND: Tuberculous meningitis (TBM) is the most common type of bacterial meningitis in the Western Cape of South Africa. Early clinical diagnosis is notoriously difficult and often delayed, with ...
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Socioeconomic factors associated with asthma prevalence and severity among children living in low-income South African communities
(Health & Medical Publishing Group, 2016-03-09)Background. Rates of asthma, poverty and social deprivation are high among young people in South Africa (SA), yet asthma interventions largely remain focused on biomedical factors. Objective. To investigate associations ...
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Children with disabling chronic conditions in the Western health subdistrict of Cape Town, South Africa : estimating numbers and service gaps
(Health & Medical Publishing Group, 2016-02-22)Background. Children with disabling chronic conditions often have extensive, complex and unmet healthcare and educational needs. They can be defined as a subset of the group of children with chronic health conditions whose ...
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Missing HIV prevention opportunities in South African children – A 7-year review
(BioMed Central, 2014-12-13)Background: The prevention of mother-to-child transmission (PMTCT) program in South Africa is now successful in ensuring HIV-free survival for most HIV-exposed children, but gaps in PMTCT coverage remain. The study ...
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It’s complicated : why do tuberculosis patients not initiate or stay adherent to treatment? a qualitative study from South Africa
(BioMed Central, 2016-11-25)Background: Individuals who test positive for active tuberculosis (TB) but do not initiate treatment present a challenge to TB programmes because they contribute to ongoing transmission within communities. To better understand ...
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Prevention and treatment of perinatal and infant tuberculosis in the HIV era
(Stellenbosch : Stellenbosch University, 2016-11-18)ENGLISH ABSTRACT : Infants (<12 months) born to women with tuberculosis are at high risk of Mycobacterium tuberculosis (M. tuberculosis) exposure, infection and disease early in life. In settings with high prevalence of ...
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The management of persistent pulmonary hypertension of the newborn : a review
(Health & Medical Publishing Group, 2016-12-14)Persistent pulmonary hypertension of the newborn is a neonatal emergency with a high mortality rate in spite of several advances in the management thereof. The underlying pathophysiology is complex and multifactorial. The ...
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Outcome of children admitted to a general highcare unit in a regional hospital in the Western Cape, South Africa
(Health & Medical Publishing Group, 2016-10-03)Background. Critically ill children are often managed in non-tertiary general intensive care units admitting both adults and children, but few data are currently available regarding paediatric outcomes in these general ...
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The complex relationship between human immunodeficiency virus infection and death in adults being treated for tuberculosis in Cape Town, South Africa
(BioMed Central, 2015)Background: Despite recognised treatment strategies, mortality associated with tuberculosis (TB) remains significant. Risk factors for death during TB treatment have been described but the complex relationship between TB ...
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Availability and acceptability of HIV counselling and testing services. a qualitative study comparing clients’ experiences of accessing HIV testing at public sector primary health care facilities or non-governmental mobile services in Cape Town, South Africa
(BioMed Central, 2015)Background: The South African government is striving for universal access to HIV counselling and testing (HCT), a fundamental component of HIV care and prevention. In the Cape Town district, Western Cape Province of South ...
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Pathways to multidrug-resistant tuberculosis diagnosis and treatment initiation : a qualitative comparison of patients’ experiences in the era of rapid molecular diagnostic tests
(BioMed Central, 2015-10-28)Background Although new molecular diagnostic tests such as GenoType MTBDRplus and Xpert® MTB/RIF have reduced multidrug-resistant tuberculosis (MDR-TB) treatment initiation times, patients’ experiences of diagnosis and ...
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HIV treatment-as-prevention research : taking the right road at the crossroads
(Public Library of Science, 2015)No abstract available
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Optimizing mycobacterial culture in smear- negative, human immunodeficiency virus- infected tuberculosis cases
(Public Library of Science, 2015)Introduction: Tuberculosis (TB) is a significant public health problem and the diagnosis in human immunodeficiency virus (HIV)—infected individuals is challenging. The use of mycobacterial culture remains an important ...
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Early ART results in greater immune reconstitution benefits in HIV-infected infants : working with data missingness in a longitudinal dataset
(Public Library of Science, 2015)Background: Early initiation of anti-retroviral treatment (ART) decreases mortality as compared to deferred treatment, but whether it preserves immune cells from early loss or promotes their recovery remains undefined. ...
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HIV testing and antiretroviral therapy initiation at birth : views from a primary care setting in Khayelitsha
(AOSIS Publishing, 2015-04-28)No abstract available.
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H1N1 influenza (‘swine ‘flu’) in the paediatric ICU in South Africa
(Health & Medical Publishing Group, 2015-09-18)No abstract available.
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