Seddon, James A.Hesseling, Anneke C.Godfrey-Faussett, PeterFielding, KatherineSchaaf, H. S.(BioMed Central, 2013-08)
Background: Young children exposed to Mycobacterium tuberculosis have a high risk of disease progression
following infection. This study aimed to determine risk factors for M. tuberculosis infection and disease in children ...
Marais, B. J.Obihara, C. C.Gie, R. P.Schaaf, H. S.Hesseling, A. C.Lombard, C.Enarson, D.Bateman, E.Beyers, N.(BMJ Publishing Group, 2005-11)
Background: Diagnosis of childhood tuberculosis is problematic and symptom based diagnostic
approaches are often promoted in high burden settings. This study aimed (i) to document the prevalence
of symptoms associated ...
Kling, Sharon(Health and Medical Publishing Group (HMPG), 2008-04)
Exercise-induced asthma (EIA) is defined
as ‘the condition in which exercise induces
symptoms of asthma in patients who have
asthma’.1 The question is whether EIA is a
distinct phenotype of asthma or whether
it is ...
Heckmann, J. M.Hansen, P.Van Toorn, R.Lubbe, E.Janse Van Rensburg, E.Wilmshurst, J. M.(Health and Medical Publishing Group (HMPG), 2012-06)
Objectives. To report the characteristics of juvenile-onset (<20
years) myasthenia gravis (MG) in Africa.
Subjects and methods. Six South African centres collected data
which included acetylcholine receptor-antibody ...
Feucht, Ute DagmarThomas, Ute DagmarForsyth, Brian William CameronKruger, Mariana(Health and Medical Publishing Group (HMPG), 2012-08)
Objective. To assess the extent to which children may be falsely diagnosed as HIV-infected, using data from an antiretroviral therapy (ART)
site in Pretoria, South Africa.
Methods. This was a retrospective patient record ...
Harris, TashneemBardien, SorayaSchaaf, H. SimonPetersen, LucretiaDe Jong, GreetjeFagan, Johannes J.(Health and Medical Publishing Group (HMPG), 2012-06)
Background. Ototoxicity following aminoglycoside treatment
for multidrug-resistant tuberculosis (MDR-TB), is a significant
problem. This study documents the incidence of ototoxicity in HIVpositive
and HIV-negative ...
Van Soelen, NeldaMandalakas, Anna M.Kirchner, H. L.Walzl, GerhardGrewal, Harleen M. S.Jacobsen, MarcHesseling, Anneke C.(BioMed Central, 2012-09)
ABSTRACT:M.tuberculosis (M.tb) is associated with enhanced T helper cell type 1 (Th1) immune responses while helminth infection is associated with T helper cell type 2 (Th2) immune responses. Our aim was to investigate ...
BACKGROUND: Juvenile idiopathic arthritis (JIA) is a disease that shows wide variations between differing
populations. Since the recent international consensus on classification criteria, JIA has been widely described ...
Adams, Vera J.Markus, Miles B.Adams, Joanita F. A.Jordaan, EsmeCurtis, BronwynDhansay, Muhammad A.Obihara, Charlie C.Fincham, John E.(Makerere University Medical School, 2005-06)
Background. South Africa has endorsed a World Health Assembly (WHA) resolution calling for control of soil-transmitted
helminths (STHs). In Cape Town, services and housing that exist in old-established suburbs should ...
Van Zyl, Johann M.Smith, JohanHawtrey, Arthur(Dovepress, 2013-03)
Background: Currently, a new generation of synthetic pulmonary surfactants is being developed that may eventually replace animal-derived surfactants used in the treatment of respiratory distress syndrome. Enlightened by ...
Background: Swallowing disorders, well recognised in adults, contribute to HIV-infection morbidity. Little data
however is available for HIV-infected children. The purpose of this study is to describe swallowing disorders ...
Innes, SteveCotton, Mark F.Haubrich, RichardConradie, Maria M.Van Niekerk, MargaretEdson, ClairRabie, HelenaJain, SoniaSun, XiaoyingZollner, Ekkehard W.Hough, StephenBrowne, Sara H.(BioMed Central, 2012-11)
Background: Despite changes in WHO guidelines, stavudine is still used extensively for treatment of pediatric HIV in the developing world. Lipoatrophy in sub-Saharan African children can be stigmatizing and have far-reaching ...
Background: In South Africa the estimated incidence of all forms of tuberculosis (TB) for 2008 was 960/100000. It was reported that all South Africans lived in districts with Directly Observed Therapy, Short-course. However, ...
Jaspan, Heather B.Huang, Lyen C.Cotton, Mark F.Whitelaw, AndrewMyer, Landon(PLOS, 2008-09-24)
Background: Serious bacterial infections are a major source of morbidity and mortality in HIV-infected children. The
spectrum of disease is wide, and responsible organisms vary according to setting. The use of antibiotic ...
Enarson, Penelope MarjorieGie, RobertEnarson, Donald A.Mwansambo, Charles(Public Library of Science -- PLOS, 2009-11)
The reduction of child mortality by two-thirds from its 1990 level by 2015—the fourth United Nations Millennium Development Goal—is a major challenge. Pneumonia accounts for much (≥20%) of this mortality in poor countries, ...
Innes, Steven Eugene Vere(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: Introduction:
Lipoatrophy is a common adverse effect of stavudine and this effect is strongly dose-dependent. Stavudine remains the most commonly used paediatric antiretroviral drug in sub-Saharan Africa, ...
Schölvinck, Elisabeth Henriëtte(Stellenbosch : Stellenbosch University, 2002)
ENGLISH ABSTRACT: Children and adults may differ in their immune function. An adequate function of the
individual's immune system is crucial to the risk for development of tuberculosis (TB)
after infection with Mycobacterium ...
Schoeman, JudithDannhauser, AndreKruger, Mariana(Health and Medical Publishing Group (HMPG), 2010-08)
Children more commonly present with protein energy malnutrition (PEM) at diagnosis of cancer in developing countries than in developed countries, depending on the type of cancer and extent of the disease. PEM at cancer ...
Kruger, Mariana(Health and Medical Publishing Group (HMPG), 2010-06)
Leukaemia means white blood. It is a disease of the white blood cells and was first described by Virchow in 1845. Leukaemia can present as an acute disease, occurring more often in the younger age groups, or as a chronic ...
Stefan, Daniela Cristina(Health and Medical Publishing Group (HMPG), 2010-07)
Childhood cancer is relatively rare, comprising less than 1% of
cases of malignant disease. Cancer is the second most common cause of death in children in Western countries, while in Africa it is not even ranked among ...