Department of Medicine

The current aetiology of malignant pleural effusion in the Western Cape Province, South Africa

Koegelenberg, C. F. N.; Bennji, S. M.; Boer, E.; Schubert, P. T.; Shaw, J. A.; Allwood, B. W.; Irusen, E. M. (Health & Medical Publishing Group, 2018-04)

Background: Malignant pleural effusion (MPE) represents a very common cause of pleural exudates, and is one of the most challenging pleural disorders to manage. This could be attributed to the paucity of high-quality ...

Inter-scallop separations of the posterior leaflet of the mitral valve : an important cause of pathological mitral regurgitation in rheumatic heart disease screening

Hunter, L. D.; Monaghan, M.; Lloyd, G.; Pecoraro, A. J. K.; Doubell, A. F.; Herbst, P. G. (BioScientifica, 2018)

The 2012 World Heart Federation (WHF) criteria for echocardiographic diagnosis of rheumatic heart disease (RHD) identify that the finding of ‘pathological’ mitral regurgitation (MR) in a screened individual increases the ...

Atrialised right ventricular myxoma in a patient with Ebstein’s anomaly

John, T. J.; Snyman, H. W.; Janson, J.; Pecoraro, A. J. K. (BioScientifica, 2018)

Ebstein’s anomaly is a rare entity affecting around 1 in 200,000 live births and accounts for less than 1% of congenital heart diseases. Ebstein’s anomaly with an associated right-sided myxoma is extremely rare, with only ...

Patterns of biopsy-proven renal disease in Cape Town, South Africa, from 1995 to 2017

Esmail, Ahmed M (Stellenbosch : Stellenbosch University, 2019-12)

Introduction: The causes, prevalence and outcomes of renal disease in developing countries may differ compared to developed countries. In most African countries, little data on the topic is available because of the lack ...

Deposition and transport of linezolid mediated by a synthetic surfactant Synsurf® within a pressurized metered dose inhaler : a Calu-3 model

Van Rensburg, Lyne; Van Zyl, Johann M.; Smith, Johan (Dove Medical Press, 2018)

Background: Previous studies in our laboratory demonstrated that a synthetic peptide containing lung surfactant enhances the permeability of chemical compounds through bronchial epithelium. The purpose of this study was ...

Teaching medical students in a new rural longitudinal clerkship : opportunities and constraints

De Villiers, Marietjie; Conradie, Hoffie; Van Schalkwyk, Susan (Levy Library Press, 2018)

Background: Medical schools in Africa are responding to the call to increase numbers of medical graduates by up-scaling decentralized clinical training. One approach to decentralized clinical training is the longitudinal ...

Introducing an e-learning solution for medical education in Liberia

Walsh, S.; De Villiers, M. R.; Golakai, V. K. (Levy Library Press, 2018)

Background: The Ebola virus epidemic and civil war in Liberia left the country in need of strengthening the health workforce. E-learning in medical education provides relevant learning opportunities for students, develops ...

Toxicity related to standard TB therapy for pulmonary tuberculosis and treatment outcomes in the REMoxTB study according to HIV status

Tweed, Conor D.; Crook, Angela M.; Dawson, Rodney; Diacon, Andreas H.; McHugh, Timothy D.; Mendel, Carl M.; Meredith, Sarah K.; Mohapi, Lerato; Murphy, Michael E.; Nunn, Andrew J.; Phillips, Patrick P. J.; Singh, Kasha P.; Spigelman, Melvin; Gillespie, Stephen H. (BMC (part of Springer Nature), 2019-08-14)

Background: The phase III REMoxTB study prospectively enrolled HIV-positive (with CD4+ count > 250 cells, not on anti-retroviral therapy) and HIV-negative patients. We investigated the incidence of adverse events and cure ...

Transcatheter aortic valve in mitral annular calcifi cation (TAV-in-MAC) : a new treatment option for mitral valve replacement in patients with severe annular calcification

Weich, Hellmuth; Van Wyk, Jacques; Hofmeyr, Lou; Vogts, Carl (South African Heart Association, 2019)

ENGLISH ABSTRACT: Severe mitral annular calcification is not an uncommon occurrence in the elderly and up to now, this has often precluded surgical replacement of the mitral valve. Initial attempts at percutaneous placement ...

7-Year experience of transcatheter aortic valve implants (TAVI) in a Western Cape private healthcare setting

Weich, Hellmuth; Liebenberg, Jacques; Van Wyk, Jacques; Vivier, Rocco; Barnard, Barry; Abelson, Mark; Phillips, Andre; Mabin, Tom (South African Heart Association, 2019)

Introduction: We describe the largest South African transcatheter aortic valve implantation (TAVI) outcome report of a single team in the Western Cape, over a 7-year period from 2009 - 2016. Methods: All patients who ...

HIV-positive patients in the intensive care unit

Parker, A.; Lahri, S.; Taljaard, J. J.; Koegelenberg, C. F. N. (Health and Medical Publishing Group, 2017)

No abstract available.

Does access to private healthcare influence potential lung cancer cure rates?

John, Thadathilankal-Jess; Plekker, Dante; Irusen, Elvis M.; Koegelenberg, Coenie F. N. (Health and Medical Publishing Group, 2017)

Background. Numerous studies show a link between poor socioeconomic status (SES) and late-stage cancer diagnosis. However, this has not been consistently shown looking at non-small-cell lung cancer (NSCLC) in isolation. ...

Berg adder (Bitis atropos) : an unusual case of acute poisoning

Wium, C. A.; Marks, C. J.; Du Plessis, C. E.; Muller, G. J. (Health and Medical Publishing Group, 2017)

A 5-year-old boy presented to hospital with mild local cytotoxic and severe neurotoxic symptoms. The neurotoxic symptoms included ptosis, fixed dilated pupils and flaccid paralysis with respiratory failure. Mild hyponatraemia ...

Calcific uraemic arteriolopathy (calciphylaxis) in patients on renal replacement therapy

Sebastian, S.; Jordaan, H. F.; Schneider, J. W.; Moosa, M. R.; Davids, M. R. (Health and Medical Publishing Group, 2017)

Background. Calcific uraemic arteriolopathy (calciphylaxis) is an unusual and potentially fatal condition characterised by small-vessel calcification and ischaemic skin necrosis. It mainly affects patients with end-stage ...

Out of hospital cardiac arrest due to spontaneous left ventricular rupture

Snyman, H.; Du Preez, L.; Pecoraro, Alfonso (South African Heart Association, 2017)

No abstract available

Embracing new techniques and new technologies in cardiac surgery – is it being done responsibly and safely?

Janson, Jacques (South African Heart Association, 2017)

Cardiac surgeons have been pioneers since the inception of this surgical field. Sixty years ago the development of the heart-lung machine paved the way for cardiac surgery. Since then many new innovations have been introduced, ...

Double atrial heart sound in a patient with 2:1 atrioventricular block

Pecoraro, Alfonso J.; Doubell, Anton F.; Herbst, Philip G. (South African Heart Association, 2017)

No abstract available

A rare cause of aortic regurgitation

Kabwe, Lorrita; Pecoraro, Alfonso (South African Heart Association, 2017)

No abstract available

Pharmacokinetic study of anti-tb drug para-aminosalicylic acid and its metabolites: a possible relationship with the development of toxicity

Adams, Kim (Stellenbosch : Stellenbosch University, 2019-04)

Background Para-aminosalicylic acid (PAS) is a bacteriostatic anti-tuberculosis (anti-TB) drug, used in the treatment of multi-drug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). While PAS has ...

Venomous spider bites in south africa: epidemiology and clinical features

Du Plessis, Catharina Elizabeth (Stellenbosch : Stellenbosch University, 2019-04)

Introduction: Worldwide the number of spider bite calls to poison centres comprises less than 2.5% of calls. Only a small proportion of spiders cause serious envenomation in humans. The known medically important spiders ...