Department of Medicine
Sub-communities within this community
Recent Submissions
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Speckle tracking echocardiography in acute lupus myocarditis : comparison to conventional echocardiography
(BioScientifica, 2017)Aims: Lupus myocarditis occurs in 5–10% of patients with systemic lupus erythematosus (SLE). No single feature is diagnostic of lupus myocarditis. Speckle tracking echocardiography (STE) can detect subclinical left ...
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A retrospective analysis of mitral valve pathology in the setting of bicuspid aortic valves
(BioScientifica, 2017)The therapeutic implications of bicuspid aortic valve associations have come under scrutiny in the transcatheter aortic valve implantation era. We evaluate the spectrum of mitral valve disease in patients with bicuspid ...
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Pyoderma gangrenosum, acne, and suppurative hidradenitis syndrome in end-stage renal disease successfully treated with adalimumab
(University of California, 2017)PASH syndrome (pyoderma gangrenosum, acne, and suppurative hidradenitis) forms part of the spectrum of autoinflammatory diseases. We report an unusual case of PASH syndrome in a patient with end-stagerenal disease (ESRD) ...
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Screening for rheumatic heart disease : is a paradigm shift required?
(BioScientifica, 2017)This focused review presents a critical appraisal of the World Heart Federation criteria for the echocardiographic diagnosis of rheumatic heart disease (RHD) and its performance in African RHD screening programmes. It ...
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Shifting tasks from pharmacy to nonpharmacy personnel for providing antiretroviral therapy to people living with HIV : a systematic review and metaanalysis
(BMJ Publishing Group, 2017-8)Objectives Lay people or non-pharmacy health workers with training could dispense antiretroviral therapy (ART) in resource-constrained countries, freeing up time for pharmacists to focus on more technical tasks. ...
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Rheumatic heart disease screening : current concepts and challenges
(Medknow Publications, 2017)Rheumatic heart disease (RHD) is a disease of poverty, is almost entirely preventable, and is the most common cardiovascular disease worldwide in those under 25 years. RHD is caused by acute rheumatic fever (ARF) which ...
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A Validated stable HPLC method for the simultaneous determination of rifampicin and 25-O-desacetyl rifampicin – evaluation of in vitro metabolism
(Akademiai Kiado, 2017)A simple, efficient, and stable high-performance liquid chromatography (HPLC) separation method for a combination of rifampicin (RIF), its major metabolite 25-O-desacetyl rifampicin (25ODESRIF), and neostigmine (NEO) was ...
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Lipoatrophy/lipohypertrophy outcomes after antiretroviral therapy switch in children in the UK/Ireland
(Public Library of Science, 2017)Background: Following widespread use of stavudine, a thymidine analogue, in antiretroviral therapy (ART) over the past three decades, up to a third of children developed lipoatrophy (LA) and/or lipohypertrophy (LH). ...
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A refined multiscale self-entropy approach for the assessment of cardiac control complexity : application to long QT syndrome type 1 patients
(MDPI, 2015-11-13)ENGLISH ABSTRACT: The study proposes the contemporaneous assessment of conditional entropy (CE) and self-entropy (sE), being the two terms of the Shannon entropy (ShE) decomposition, as a function of the time scale via ...
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Residual renal function in chronic dialysis is not associated with reduced erythropoietin-stimulating agent dose requirements : a cross-sectional study
(BioMed Central, 2017-11-25)Background: Anaemia is a very common problem in patients with end-stage kidney disease (ESKD) and the use of erythropoietin-stimulating agents (ESA) has revolutionised its treatment. Residual renal function (RRF) is ...
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Strengthening renal registries and ESRD research in Africa
(Elsevier, 2017)ENGLISH ABSTRACT: In Africa the combination of non-communicable diseases, infectious diseases, exposure to environmental toxins and acute kidney injury related to trauma and childbirth are driving an epidemic of chronic ...
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An overview of the biological disease modifying drugs available for arthritic conditions in South Africa
(Taylor & Francis, 2016)ENGLISH ABSTRACT: The past decade has seen a major change in the treatment options and strategies for rheumatoid arthritis (RA) and the other immune-mediated arthritic diseases. The disease modifying antirheumatic drugs ...
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An effective approach to chronic kidney disease in South Africa
(Health & Medical Publishing Group, 2016)ENGLISH ABSTRACT: Very few patients with end-stage kidney disease in South Africa receive renal replacement treatment (RRT), despite the rapidly growing demand, because of resource constraints. Nephrologists who agonise ...
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An approach to the patient with a suspected tachycardia in the emergency department
(Health & Medical Publishing Group, 2016)ENGLISH ABSTRACT: Patients present to the emergency department with either an ongoing tachycardia or a history suspicious of a tachycardia. Either way, the tachycardia needs to be documented, preferably on a 12-lead ...
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An approach to the patient with suspected pericardial disease
(Health & Medical Publishing Group, 2016)ENGLISH ABSTRACT: Diseases of the pericardium commonly manifest in one of three ways: acute pericarditis, pericardial effusion and constrictive pericarditis. In the developed world, the most common cause of acute pericarditis ...
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The impact of HIV infection on the presentation of lung cancer in South Africa
(Health & Medical Publishing Group, 2016)ENGLISH ABSTRACT: Background. Despite the very high background prevalence of HIV and smoking-related diseases in sub-Saharan Africa, very little is known about the presentation of lung cancer in HIV-infected individuals. ...
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Clinical findings and genetic screening for copy number variation mutations in a cohort of South African patients with Parkinson’s disease
(Health & Medical Publishing Group, 2016)ENGLISH ABSTRACT: Background. Parkinson’s disease (PD), with a prevalence of up to 4% in Western countries, appears to be less common in Africa, possibly in part because of genetic factors. African studies investigating ...
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Angio-oedema associated with colistin
(Health & Medical Publishing Group, 2016)ENGLISH ABSTRACT: A 50-year-old woman known to have type 1 diabetes mellitus presented with a rare case of angio-oedema associated with colistin use. The angio-oedema was temporally associated with the use and discontinuation ...
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The heart team, TAVI and natural selection
(South African Heart Association, 2016)ENGLISH ABSTRACT: The announcement in 2002 that Alan Cribier had performed the first Transcatheter Aortic Valve Implantation (TAVI) ranked right up there with the announcement that the first heart transplant had been ...
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Delivering cardiac care : the next frontier
(South African Heart Association, 2016)ENGLISH ABSTRACT: The 17th annual South African Heart congress, co-hosted with the annual meeting of the World Society of Cardiothoracic surgery, brings together both local and international pioneers in the field of ...
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Tri-leaflet mitral valves – when lightning strikes thrice
(South African Heart Association, 2016)ENGLISH ABSTRACT: Mitral valves are well known to be bi-leaflet structures with attachments from both leaflets (anterior and posterior) to both papillary muscles (anterolateral and posteromedial). Congenital abnormalities ...
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When opportunity knocks
(South African Heart Association, 2016)ENGLISH ABSTRACT: Constrictive pericarditis remains a common medical problem in developing countries where it frequently complicates tuberculous pericarditis. In addition, it is not infrequently seen in the developed world ...
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Cardiology training in South Africa – on the brink?
(South African Heart Association, 2016)ENGLISH ABSTRACT: More often than not, when we use the expression “on the brink”, we are referring to an impending bad situation. On the edge of a cliff without wings so to speak…, on the brink of disaster…, on the brink ...
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Patient-reported barriers to adherence to antiretroviral therapy : a systematic review and meta-analysis
(Public Library of Science, 2016)ENGLISH SUMMARY : Background: Maintaining high levels of adherence to antiretroviral therapy (ART) is a challenge across settings and populations. Understanding the relative importance of different barriers to adherence ...
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How to evaluate health-related quality of life and its association with medication adherence in pulmonary tuberculosis – designing a prospective observational study in South Africa
(Frontiers Media, 2016)Introduction: Health-related quality of life (HRQOL) has become an important measure to identify and shape effective and patient-relevant healthcare interventions innovations through outcomes. Adherence to tuberculosis ...
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Peritoneal dialysis technique survival at Tygerberg Hospital in Cape Town, South Africa
(African Association of NephrologyPublisher's version, 2017)Background: The use of peritoneal dialysis (PD) as a treatment modality for patients with end-stage renal disease (ESRD) has been declining in many countries over the past few years. One of the reasons is technique failure, ...
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Peritoneal dialysis technique survival at Tygerberg hospital in Cape Town, South Africa
(Stellenbosch : Stellenbosch University, 2017-03)Background: Peritoneal dialysis (PD) technique failure invariably occurs in patients with end-stage renal disease who are treated with this modality and results in increased morbidity and mortality. Various factors have ...
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Intradialytic hypertension during chronic haemodialysis and subclinical fluid overload assessed by bioimpedance spectroscopy
(Oxford University Press European Renal Association, 2016-06-19)Background: Intradialytic hypertension (IDH) increases morbidity and mortality. The prevalence in South Africa is unknown. The pathogenesis is unclear, but it has been suggested that IDH may be due to subclinical fluid ...
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A renal registry for Africa : first steps
(Oxford University Press European Renal Association, 2016)ENGLISH ABSTRACT: There is a dearth of data on end-stage renal disease (ESRD) in Africa. Several national renal registries have been established but have not been sustainable because of resource limitations. The African ...
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Ultrathin bronchoscopy for solitary pulmonary lesions in a region endemic for tuberculosis : a randomised pilot trial
(BioMed Central, 2016)Background: The evaluation of solitary pulmonary lesions (SPL) requires a balance between procedure-related morbidity and diagnostic yield, particularly in areas where tuberculosis (TB) is endemic. Data on ultrathin ...
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