• 

  Staff testing for COVID-19 via an online pre-registration form 

  Moolla, Muhammad Saadiq; Parker, Arifa; Parker, Mohammed Aslam; Sithole, Sthembiso; Amien, Leila; Chiecktey, Rubeena; Bawa, Tasneem; Mowlana, Abdurasiet (medRxiv, 2020)

  Background: Healthcare workers are at increased risk of contracting SARS-CoV-2 and potentially causing institutional outbreaks. Staff testing is critical in identifying and isolating infected individuals while also reducing ...
• 

  Accelerating clinical evaluation of repurposed combination therapies for COVID-19 

  Rayner, Craig R.; Dron, Louis; Park, Jay J. H.; Decloedt, Eric H.; Cotton, Mark F.; Niranjan, Vis; Smith, Patrick F.; Dodds, Michael G.; Brown, Fran; Reis, Gilmar; Wesche, David; Mills, Edward J. (American Society of Tropical Medicine and Hygiene, 2020-08-21)

  As the global COVID-19 pandemic continues, unabated and clinical trials demonstrate limited effective pharmaceutical interventions, there is a pressing need to accelerate treatment evaluations. Among options for accelerated ...
• 

  Artemisia Spp. derivatives for COVID-19 treatment : anecdotal use, political hype, treatment potential, challenges, and road map to randomized clinical trials 

  Kapepula, Paulin M.; Kabengele, Jimmy K.; Kingombe, Micheline; Van Bambeke, Francoise; Tulkens, Paul M.; Kishabongo, Antoine Sadiki; Decloedt, Eric; Zumla, Adam; Tiberi, Simon; Suleman, Fatima; Tshilolo, Leon; Muyembe-TamFum, Jean-Jacques; Zumla, Alimuddin; Nachega, Jean B. (American Society of Tropical Medicine and Hygiene, 2020)

  The world is currently facing a novel COVID-19 pandemic caused by SARS-CoV-2 that, as of July 12, 2020, has caused a reported 12,322,395 cases and 556,335 deaths. To date, only two treatments, remdesivir and dexamethasone, ...
• 

  High HIV prevalence in an early cohort of hospital admissions with COVID-19 in Cape Town, South Africa 

  Parker, A.; Koegelenberg, C. F. N.; Moolla, M. S.; Louw, E. H.; Mowlana, A.; Nortje, A.; Ahmed, R.; Brittain, N.; Lalla, U.; Allwood, B. W.; Prozesky, H.; Schrueder, N.; Taljaard, J. J. (Health & Medical Publishing Group, 2020)

  Background. South Africa (SA) has a high prevalence of HIV and tuberculosis. Cape Town was the SA metropole most affected in the early stages of the COVID-19 pandemic. Early observational data from Africa may provide ...
• 

  Transition from restrictive to obstructive lung function impairment during treatment and follow-up of active tuberculosis 

  Allwood, Brian W.; Maasdorp, Elizna; Kim, Grace J.; Cooper, Christopher B.; Goldin, Jonathan; Van Zyl-Smit, Richard N.; Bateman, Eric D.; Dawson, Rodney (Dove Medical Press, 2020)

  Background: Pulmonary tuberculosis (PTB) is associated with many forms of chronic lung disease including the development of chronic airflow obstruction (AFO). However, the nature, evolution and mechanisms responsible for ...
• 

  Screening strategies for adults with type 2 diabetes mellitus : a systematic review protocol 

  Mearns, Helen; Otiku, Paul K.; Shelton, Mary; Kredo, Tamara; Kagina, Benjamin M.; Schmidt, Bey-Marrie (BMC (part of Springer Nature), 2020-07-13)

  Background: There is limited evidence on whether screening for type 2 diabetes mellitus affects health outcomes. A recent systematic review of randomised clinical trials found only one trial that met their inclusion ...
• 

  A massive pericardial effusion in South Africa is not always due to tuberculosis 

  Ntshalintshali, Sipho; Mhlana, Nontembiso; Moosajee, Farzana; Abousriwiel, Riyad; George, Kiran; Du Toit, Riette (South African Heart Association, 2020)

  South Africa (SA) has a high incidence of tuberculosis. Medical conditions mimicking tuberculosis often result in erroneous treatment with antitubercular therapy (ATT) before a definitive diagnosis is made. We report on 2 ...
• 

  Mobile health technology for enhancing the COVID-19 response in Africa : a potential game changer? 

  Nachega, Jean B.; Leisegang, Rory; Kallay, Oscar; Mills, Edward J.; Zumla, Alimuddin; Lester, Richard T. (American Society of Tropical Medicine and Hygiene, 2020)

  The WHO Africa Region is experiencing an increase in the number of novel COVID-19 cases. As of May 20, 2020, 63,521 cases with 1,796 deaths (2.8% case fatality) have been reported from 45 countries.1 Although these ...
• 

  COVID-19 in Africa : care and protection for frontline healthcare workers 

  Chersich, Matthew F.; Gray, Glenda; Fairlie, Lee; Eichbaum, Quentin; Mayhew, Susannah; Allwood, Brian W.; English, Rene; Scorgie, Fiona; Luchters, Stanley; Simpson, Greg; Mosalman Haghighi, Marjan; Duc Pham, Minh; Rees, Helen (BioMed Central, 2020)

  Medical staff caring for COVID-19 patients face mental stress, physical exhaustion, separation from families, stigma, and the pain of losing patients and colleagues. Many of them have acquired SARS-CoV-2 and some have ...
• 

  The utility of high-flow nasal cannula oxygen therapy in the management of respiratory failure secondary to COVID-19 pneumonia 

  Lalla, Usha; Allwood, Brian W.; Louw, Elizabeth H.; Nortje, Andre; Parker, Arifa; Taljaard, Jantjie J.; Moodley, Desiree; Koegelenberg, Coenraad F. N. (Health & Medical Publishing Group, 2020-05-07)

  COVID-19 is a potentially fatal infection caused by SARS-CoV-2.[1] As of 4 May 2020, more than 6 000 cases had been confirmed in South Africa (SA) with numbers rising steadily, a situation that will place a major strain ...
• 

  Current evidence for directed and supportive investigational therapies against COVID-19 

  Van Rensburg, R.; Pillay-Fuentes Lorente, V.; Decloedt, E. H. (Health & Medical Publishing Group, 2020-04-30)

  ENGLISH ABSTRACT: Coronavirus disease 2019 (COVID-19) is a global health crisis. There is currently a great need for effective and safe therapies directed at the disease, but no drugs are presently registered for use in ...
• 

  COVID-19 travel restrictions and the International Health Regulations : call for an open debate on easing of travel restrictions 

  Petersen, E.; McCloskey, B.; Hui, D. S.; Kock, R. A.; Ntoumi, F.; Memish, Z. A.; Kapata, N.; Azhar, E. I.; Pollack, M.; Madoff, L. C.; Hamer, D. H.; Nachega, Jean B.; Pshenichnaya, N.; Zumla, A. (Elsevier, 2020)

  ENGLISH ABSTRACT: The COVID-19 pandemic caused by the novel coronavirus (SARS-CoV-2) has caused national governments worldwide to mandate several generic infection control measures such as physical distancing, self-isolation, ...
• 

  Chloroquine and hydroxychloroquine for the prevention or treatment of Novel Coronavirus Disease (COVID-19) in Africa : caution for inappropriate off-label use in healthcare settings 

  Abena, Pascale M.; Decloedt, Eric H.; Bottieau, Emmanuel; Suleman, Fatima; Adejumo, Prisca; Sam-Agudu, Nadia A.; TamFum, Jean-Jacques Muyembe; Seydi, Moussa; Eholie, Serge P.; Mills, Edward J.; Kallay, Oscar; Zumla, Alimuddin; Nachega, Jean B. (American Society of Tropical Medicine and Hygiene, 2020)

  ENGLISH ABSTRACT: The novel severe acute respiratory syndrome-coronavirus-2 pandemic has spread to Africa, where nearly all countries have reported laboratory-confirmed cases of novel coronavirus disease (COVID-19). ...
• 

  Leadership and early strategic response to the SARS-CoV- 2 pandemic at a COVID-19 designated hospital in South Africa 

  Parker, A.; Karamchand, S.; Schrueder, N.; Lahri, S.; Rabie, H.; Aucamp, A.; Abrahams, R.; Ciapparelli, P.; Erasmus, D. S.; Cotton, M. F.; Lalla, U.; Leisegang, Rory; Meintjes, J.; Mistry, R.; Moosa, M. R.; Mowlana, A.; Koegelenberg, C. F. N.; Prozesky, H.; Smith, W.; Van Schalkwyk, M.; Taljaard, J. J. (Health & Medical Publishing Group, 2020-04-23)

  While many countries are preparing to face the COVID-19 pandemic, the reported cases in Africa remain low. With a high burden of both communicable and non-communicable disease and a resource-constrained public healthcare ...
• 

  Renal denervation : mechanisms and clinical aspects 

  Heradien, Marshall J.; Van Der Bijl, Pieter; Brink, Paul A. (African Association of Nephrology, 2020)

  ENGLISH ABSTRACT: Hypertension is a global health issue of paramount importance, which has not spared the African continent where an unacceptably high prevalence of uncontrolled blood pressure prevails among its population. ...
• 

  Optimising influenza vaccination during a SARS-CoV-2 epidemic in South Africa could help maintain the integrity of our healthcare system 

  Preiser, Wolfgang; Mendelson, Marc; Taljaard, Jantjie (Health & Medical Publishing Group, 2020)

  ENGLISH ABSTRACT: The novel infectious disease coronavirus disease 2019 (COVID-19), first reported in late December 2019 in Wuhan, China, seems increasingly unlikely to be contained, resulting in the first pandemic of ...
• 

  Benefit v. risk when using chloroquine in patients with severe COVID-19 disease 

  Decloedt, Eric H.; Allwood, Brian W.; Parker, Arifa; Koegelenberg, Coenraad F. N.; Blockman, Marc; Taljaard, Jantjie; Reuter, Helmuth (Health & Medical Publishing Group, 2020-04-02)

  ENGLISH ABSTRACT: Chloroquine (CQ) is widely advocated as treatment for coronavirus disease 2019 (COVID-19), including the president of the USA publicly supporting the use of hydroxychloroquine (HCQ) as a ‘game-changer’ ...
• 

  Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics 

  Kriel, Jurgen; Muller-Nedebock, Kristian; Maarman, Gerald; Mbizana, Siyasanga; Ojuka, Edward; Klumperman, Bert; Loos, Ben (Nature Research, 2018-07-09)

  Glioblastoma Multiforme (GBM) is known to be one of the most malignant and aggressive forms of brain cancer due to its resistance to chemotherapy. Recently, GBM was found to not only utilise both oxidative phosphorylation ...
• 

  Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson’s Disease, Alzheimer’s Disease and Type 2 Diabetes Mellitus 

  De Waal, Greta M.; Engelbrecht, Lize; Davis, Tanja; De Villiers, Willem J. S.; Kell, Douglas B.; Pretorius, Etheresia (Nature Research, 2018-11-14)

  Many chronic diseases, including those classified as cardiovascular, neurodegenerative, or autoimmune, are characterized by persistent inflammation. The origin of this inflammation is mostly unclear, but it is typically ...
• 

  Evaluation of locally manufactured patient-specific custom made implants for cranial defects using a silicone mould 

  Vlok, A. J.; Naidoo, S.; Kamat, A. S.; Lamprecht, D. (Health and Medical Publishing Group, 2018)

  Background: Cranial vault defects can pose a significant problem for neurosurgeons where autologous bone is no longer available for cranioplasty. Numerous materials exist to create implants which include polymethyl ...

View more