Department of Medicine
Sub-communities within this community
Recent Submissions
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Redefining effusive-constrictive pericarditis with echocardiography
(Korean Society of Journal of Cardiovascular Ultrasound Office, 2016-12)Background: Effusive-constrictive pericarditis (ECP) is traditionally diagnosed by using the expensive and invasive technique of direct pressure measurements in the pericardial space and the right atrium. The aim of this ...
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Tuberculous pericarditis : challenges and controversies in the modern era
(South African Heart Association, 2016)Tuberculous pericarditis (TBP) continues to wreak havoc across Sub-Saharan Africa (SSA). Despite more than 5 decades of treatment and research into TBP, we are not much closer to alleviating the suffering and mortality ...
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Persistant left superior vena cava – the value of an agitated saline contrast study
(South African Heart Association, 2014)A persistant left superior vena cava (PLSVC) draining to the coronary sinus (CS) is the most common venous anomaly of the thorax, affecting approximately 0.5% - 2% of the general population, and is present in up to 10% of ...
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Management of aortic stenosis in pregnancy
(South African Heart Association, 2014)Aortic stenosis in pregnancy is most commonly related to congenital or bicuspid aortic stenosis, which is associated with an aortopathy and ascending aortic dilatation. The management of AS in pregnancy is based on a few ...
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Closure of pulmonary arterio-venous malformations in a patient with a novel form of Hereditary Haemorrhagic Telangiectasia
(South African Heart Association, 2014)Image in Cardiology: Hereditary Haemorrhagic Telangiectasia.
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Intervention for congenital and structural heart disease : beyond the cradle
(South African Heart Association, 2014)During the last four decades we have seen an exponential growth in interventions (both medical and invasive) to diagnose and treat adult cardiac disorders. Coronary stents are in their fourth generation and the developments ...
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Screening for asymptomatic rheumatic heart disease : understanding the mechanisms key to the diagnostic criteria
(South African Heart Association, 2015)This focussed review describes important problems experienced in the world of echocardiographic screening for asymptomatic rheumatic heart disease (RHD). It offers a critical appraisal of the screening criteria and their ...
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Post-traumatic, intrapulmonary arteriovenous fistula : diagnosis by trans-oesophageal echocardiography
(South African Heart Association, 2015)Abstract not available
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Evaluation of the SUNHEART cardiology outreach programme
(South African Heart Association, 2015)Introduction: The demand for advanced cardiac care and specialised interventions is on the increase and this results in bottlenecks and increased waiting times for patients who require advanced cardiac care. By decentralising ...
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The association between tissue non-specific alkaline phosphatase expression and differentiation of mesenchymal stromal cells
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH SUMMARY: Diseases resulting from the dysregulation of adipocyte and osteoblast differentiation include diabetes type II and osteoporosis. Both adipocytes and osteoblasts are derived from the same progenitor cell ...
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Survival and re-aerosolization in dust of mycobacterium smegmatis - a surrogate for mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH SUMMARY : Background: Mycobacterium tuberculosis (M. tuberculosis) is essentially an airborne pathogen transmitted via aerosols. It remains viable in the soil and outside its hosts for extended periods of time. It ...
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Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa
(BioMed Central, 2016-03-11)Introduction: Tuberculosis (TB) is a leading cause of morbidity and mortality in South Africa. Clinical parameters are important objective outcomes in TB; however they often are not directly correlated with subjective ...
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Preparedness of institutions around the world for managing patients with Ebola virus disease: an infection control readiness checklist
(BioMed Central, 2015-06-08)Background: In response to global concerns about the largest Ebola virus disease (EVD), outbreak to-date in West Africa documented healthcare associated transmission and the risk of global spread, the International Society ...
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Quality of life in patients on chronic dialysis in South Africa : a comparative mixed methods study
(BioMed Central, 2017-01-05)Background: The increasing prevalence of treated end-stage renal disease and low transplant rates in Africa leads to longer durations on dialysis. Dialysis should not only be aimed at prolonging lives but also improve ...
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A 3-year survey of acute poisoning exposures in infants reported in telephone calls made to the Tygerberg Poison Information Centre, South Africa
(Health & Medical Publishing Group, 2016-03)ENGLISH ABSTRACT: Background. Infants undergo rapid development changes and are particularly vulnerable to toxic chemicals. Identifying and evaluating the toxic risks that exist in this age group could be very valuable ...
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The implications of HIV treatment on the HIV-malaria coinfection dynamics : a modeling perspective
(Hindawi, 2015-07)Most hosts harbor multiple pathogens at the same time in disease epidemiology. Multiple pathogens have the potential for interaction resulting in negative impacts on host fitness or alterations in pathogen transmission ...
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Education and training for medicines development, regulation, and clinical research in emerging countries
(Frontiers Media, 2015)The aim of this satellite workshop held at the 17th World Congress of Basic and Clinical Pharmacology (WCP2014) was to discuss the needs, optimal methods and practical approaches for extending education and teaching of ...
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Validation of two prediction models of undiagnosed chronic kidney disease in mixed-ancestry South Africans
(BioMed Central, 2015-07-04)Background: Chronic kidney disease (CKD) is a global challenge. Risk models to predict prevalent undiagnosed CKD have been published. However, none was developed or validated in an African population. We validated the Korean ...
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A comparison of death recording by health centres and civil registration in South Africans receiving antiretroviral treatment
(International AIDS Society, 2015-12-16)Introduction: There is uncertainty regarding the completeness of death recording by civil registration and by health centres in South Africa. This paper aims to compare death recording by the two systems, in cohorts of ...
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Aberrant apoptotic response of colorectal cancer cells to novel nucleoside analogues
(Public Library of Science, 2015)Despite the increased understanding of colorectal cancer and the introduction of targeted drug therapy, the metastatic phase of the disease remains refractory to treatment. Since the deregulation of normal apoptosis ...
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The role of point-of-care blood testing for ketones in the diagnosis of diabetic ketoacidosis
(Health and Medical Publishing Group, 2015)Background. Urine dipstick testing for ketones is widely used when diabetic ketoacidosis (DKA) is suspected in patients with hyperglycaemia. If urinary ketones are positive, patients are referred for further management – ...
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The diagnostic accuracy of integrated positron emission tomography/computed tomography in the evaluation of pulmonary mass lesions in a tuberculosis-endemic area
(Health and Medical Publishing Group, 2015)Background. Integrated positron emission tomography/computed tomography (PET-CT) is a well-validated modality for assessing pulmonary mass lesions and specifically for estimating risk of malignancy. Tuberculosis (TB) ...
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The real value of endobronchial ultrasound
(Health and Medical Publishing Group, 2015)Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become a standard procedure worldwide, used in conjunction with bronchoscopy to obtain biopsies for mediastinal disorders. A 67-year-old man ...
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Recommendations for the use of bronchial thermoplasty in the management of severe asthma
(Health & Medical Publishing Group, 2015)There are approximately 3 million asthma suffers in South Africa, and the national death rate is ranked as one of the highest in the world. Approximately 5% have severe asthma (uncontrolled despite being adherent on maximal ...
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Meeting the challenges in the diagnosis of inflammatory myopathies
(Health & Medical Publishing Group, 2015)Inflammatory myopathy (IM) is a rubric term to describe a heterogeneous group of muscle diseases typified by dermatomyositis and polymyositis. The current classifications are unsatisfactory, but IM associated with other ...
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Lung volume reduction in chronic obstructive pulmonary disease
(Health & Medical Publishing Group, 2015)Pathognomonic features of advanced emphysema include a markedly reduced alveolar surface area due to the formation of blebs and bullae and significantly reduced elastic recoil. The aim of lung volume reduction, which can ...
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Important causes of chronic kidney disease in South Africa
(Health & Medical Publishing Group, 2015)In hypertensive patients without chronic kidney disease (CKD) the goal is to keep blood pressure (BP) at ≤140/90 mmHg. When CKD is present, especially where there is proteinuria of ≥0.5 g/day, the goal is a BP of ≤130/80 ...
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Application of Caco-2 cell line in herb-drug interaction studies : current approaches and challenges
(Canadian Society for Pharmaceutical Sciences, 2014-01)The Caco-2 model is employed in pre-clinical investigations to predict the likely gastrointestinal permeability of drugs because it expresses cytochrome P450 enzymes, transporters, microvilli and enterocytes of identical ...
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Biomarkers of HIV-associated cancer
(Libertas Academica, 2014)Cancer biomarkers have provided great opportunities for improving the management of cancer patients by enhancing the efficiency of early detection, diagnosis, and efficacy of treatment. Every cell type has a unique molecular ...
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Low-Pass filtering approach via empirical mode decomposition improves short-scale entropy-based complexity estimation of QT interval variability in long QT syndrome type 1 patients
(MDPI, 2014-09-05)Entropy-based complexity of cardiovascular variability at short time scales is largely dependent on the noise and/or action of neural circuits operating at high frequencies. This study proposes a technique for canceling ...
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