Department of Medicine
Sub-communities within this community
Recent Submissions
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Strengthening renal registries and ESRD research in Africa
(Elsevier, 2017)ENGLISH ABSTRACT: In Africa the combination of non-communicable diseases, infectious diseases, exposure to environmental toxins and acute kidney injury related to trauma and childbirth are driving an epidemic of chronic ...
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An effective approach to chronic kidney disease in South Africa
(Health & Medical Publishing Group, 2016)ENGLISH ABSTRACT: Very few patients with end-stage kidney disease in South Africa receive renal replacement treatment (RRT), despite the rapidly growing demand, because of resource constraints. Nephrologists who agonise ...
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An approach to the patient with suspected pericardial disease
(Health & Medical Publishing Group, 2016)ENGLISH ABSTRACT: Diseases of the pericardium commonly manifest in one of three ways: acute pericarditis, pericardial effusion and constrictive pericarditis. In the developed world, the most common cause of acute pericarditis ...
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The impact of HIV infection on the presentation of lung cancer in South Africa
(Health & Medical Publishing Group, 2016)ENGLISH ABSTRACT: Background. Despite the very high background prevalence of HIV and smoking-related diseases in sub-Saharan Africa, very little is known about the presentation of lung cancer in HIV-infected individuals. ...
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The heart team, TAVI and natural selection
(South African Heart Association, 2016)ENGLISH ABSTRACT: The announcement in 2002 that Alan Cribier had performed the first Transcatheter Aortic Valve Implantation (TAVI) ranked right up there with the announcement that the first heart transplant had been ...
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Delivering cardiac care : the next frontier
(South African Heart Association, 2016)ENGLISH ABSTRACT: The 17th annual South African Heart congress, co-hosted with the annual meeting of the World Society of Cardiothoracic surgery, brings together both local and international pioneers in the field of ...
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Cardiology training in South Africa – on the brink?
(South African Heart Association, 2016)ENGLISH ABSTRACT: More often than not, when we use the expression “on the brink”, we are referring to an impending bad situation. On the edge of a cliff without wings so to speak…, on the brink of disaster…, on the brink ...
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Patient-reported barriers to adherence to antiretroviral therapy : a systematic review and meta-analysis
(Public Library of Science, 2016)ENGLISH SUMMARY : Background: Maintaining high levels of adherence to antiretroviral therapy (ART) is a challenge across settings and populations. Understanding the relative importance of different barriers to adherence ...
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Peritoneal dialysis technique survival at Tygerberg Hospital in Cape Town, South Africa
(African Association of NephrologyPublisher's version, 2017)Background: The use of peritoneal dialysis (PD) as a treatment modality for patients with end-stage renal disease (ESRD) has been declining in many countries over the past few years. One of the reasons is technique failure, ...
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Peritoneal dialysis technique survival at Tygerberg hospital in Cape Town, South Africa
(Stellenbosch : Stellenbosch University, 2017-03)Background: Peritoneal dialysis (PD) technique failure invariably occurs in patients with end-stage renal disease who are treated with this modality and results in increased morbidity and mortality. Various factors have ...
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A renal registry for Africa : first steps
(Oxford University Press European Renal Association, 2016)ENGLISH ABSTRACT: There is a dearth of data on end-stage renal disease (ESRD) in Africa. Several national renal registries have been established but have not been sustainable because of resource limitations. The African ...
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Ultrathin bronchoscopy for solitary pulmonary lesions in a region endemic for tuberculosis : a randomised pilot trial
(BioMed Central, 2016)Background: The evaluation of solitary pulmonary lesions (SPL) requires a balance between procedure-related morbidity and diagnostic yield, particularly in areas where tuberculosis (TB) is endemic. Data on ultrathin ...
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Epidemiology of lower respiratory infection and pneumonia in South Africa (1997 – 2015) : a systematic review protocol
(BMJ Publishing Group, 2016)Introduction: Lower respiratory infections (LRIs) and pneumonia are among the leading causes of death worldwide, especially in children aged under 5 years, and these patterns are reflected in the South African population. ...
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Modelling the healthcare costs of skin cancer in South Africa
(BioMed Central, 2016)Background: Skin cancer is a growing public health problem in South Africa due to its high ambient ultraviolet radiation environment. The purpose of this study was to estimate the annual health system costs of ...
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Inhibitory interactions of Aspalathus linearis (Rooibos) extracts and compounds, aspalathin and Z-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid, on cytochromes metabolizing hypoglycemic and hypolipidemic drugs
(MDPI, 2016-11-12)Rooibos extract, due to its glucose and lipid lowering effects, has potential as a nutraceutical for improvement of metabolic dysfunction. Potential herb-drug interactions as a result of the use of natural products are of ...
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Inhibition of CYP2B6 by medicinal plant extracts : implication for use of efavirenz and nevirapine-based highly active anti-retroviral therapy (HAART) in resource-limited settings
(MDPI, 2016-02-16)Highly active antiretroviral therapy (HAART) has greatly improved health parameters of HIV infected individuals. However, there are several challenges associated with the chronic nature of HAART administration. For populations ...
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Moderate to severe HIV-associated neurocognitive impairment : a randomized placebo-controlled trial of lithium
(Wolters Kluwer Health, 2016-11)Background: HIV-associated neurocognitive disorder (HAND) remains highly prevalent despite effective anti-retroviral therapy (ART). A number of adjunctive pharmacotherapies for HAND have been studied with disappointing ...
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Redefining effusive-constrictive pericarditis with echocardiography
(Korean Society of Journal of Cardiovascular Ultrasound Office, 2016-12)Background: Effusive-constrictive pericarditis (ECP) is traditionally diagnosed by using the expensive and invasive technique of direct pressure measurements in the pericardial space and the right atrium. The aim of this ...
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Simulating therapeutic drug monitoring results for dose individualisation to maintain investigator blinding in a randomised controlled trial
(BioMed Central, 2017-06-07)Background: Therapeutic drug monitoring (TDM) is essential practice when dosing drugs with a narrow therapeutic index in order to achieve a plasma drug concentration within a narrow target range above the efficacy concentration ...
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Tuberculous pericarditis : challenges and controversies in the modern era
(South African Heart Association, 2016)Tuberculous pericarditis (TBP) continues to wreak havoc across Sub-Saharan Africa (SSA). Despite more than 5 decades of treatment and research into TBP, we are not much closer to alleviating the suffering and mortality ...
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Persistant left superior vena cava – the value of an agitated saline contrast study
(South African Heart Association, 2014)A persistant left superior vena cava (PLSVC) draining to the coronary sinus (CS) is the most common venous anomaly of the thorax, affecting approximately 0.5% - 2% of the general population, and is present in up to 10% of ...
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Management of aortic stenosis in pregnancy
(South African Heart Association, 2014)Aortic stenosis in pregnancy is most commonly related to congenital or bicuspid aortic stenosis, which is associated with an aortopathy and ascending aortic dilatation. The management of AS in pregnancy is based on a few ...
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Closure of pulmonary arterio-venous malformations in a patient with a novel form of Hereditary Haemorrhagic Telangiectasia
(South African Heart Association, 2014)Image in Cardiology: Hereditary Haemorrhagic Telangiectasia.
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Intervention for congenital and structural heart disease : beyond the cradle
(South African Heart Association, 2014)During the last four decades we have seen an exponential growth in interventions (both medical and invasive) to diagnose and treat adult cardiac disorders. Coronary stents are in their fourth generation and the developments ...
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Screening for asymptomatic rheumatic heart disease : understanding the mechanisms key to the diagnostic criteria
(South African Heart Association, 2015)This focussed review describes important problems experienced in the world of echocardiographic screening for asymptomatic rheumatic heart disease (RHD). It offers a critical appraisal of the screening criteria and their ...
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Post-traumatic, intrapulmonary arteriovenous fistula : diagnosis by trans-oesophageal echocardiography
(South African Heart Association, 2015)Abstract not available
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Evaluation of the SUNHEART cardiology outreach programme
(South African Heart Association, 2015)Introduction: The demand for advanced cardiac care and specialised interventions is on the increase and this results in bottlenecks and increased waiting times for patients who require advanced cardiac care. By decentralising ...
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The association between tissue non-specific alkaline phosphatase expression and differentiation of mesenchymal stromal cells
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH SUMMARY: Diseases resulting from the dysregulation of adipocyte and osteoblast differentiation include diabetes type II and osteoporosis. Both adipocytes and osteoblasts are derived from the same progenitor cell ...
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Survival and re-aerosolization in dust of mycobacterium smegmatis - a surrogate for mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH SUMMARY : Background: Mycobacterium tuberculosis (M. tuberculosis) is essentially an airborne pathogen transmitted via aerosols. It remains viable in the soil and outside its hosts for extended periods of time. It ...
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Retinopathy of prematurity screening criteria and workload implications at Tygerberg Children’s Hospital, South Africa : a cross-sectional study
(Health & Medical Publishing Group, 2016-05-12)Background. Screening guidelines for retinopathy of prematurity (ROP) used in high-income countries are not appropriate for middle- income countries, and screening requirements may vary even between units within one ...
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