Department of Medicine
Sub-communities within this community
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Cardiology [58]
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Dermatology [8]
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Endocrinology [8]
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Gastroenterology [4]
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General Medicine [36]
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Infectious Diseases [24]
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Nephrology [28]
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Neurology [15]
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Pulmonology [37]
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Rheumatology [4]
Recent Submissions
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Current evidence for directed and supportive investigational therapies against COVID-19
(Health & Medical Publishing Group, 2020-04-30)ENGLISH ABSTRACT: Coronavirus disease 2019 (COVID-19) is a global health crisis. There is currently a great need for effective and safe therapies directed at the disease, but no drugs are presently registered for use in ... -
COVID-19 travel restrictions and the International Health Regulations : call for an open debate on easing of travel restrictions
(Elsevier, 2020)ENGLISH ABSTRACT: The COVID-19 pandemic caused by the novel coronavirus (SARS-CoV-2) has caused national governments worldwide to mandate several generic infection control measures such as physical distancing, self-isolation, ... -
Chloroquine and hydroxychloroquine for the prevention or treatment of Novel Coronavirus Disease (COVID-19) in Africa : caution for inappropriate off-label use in healthcare settings
(American Society of Tropical Medicine and Hygiene, 2020)ENGLISH ABSTRACT: The novel severe acute respiratory syndrome-coronavirus-2 pandemic has spread to Africa, where nearly all countries have reported laboratory-confirmed cases of novel coronavirus disease (COVID-19). ... -
Renal denervation : mechanisms and clinical aspects
(African Association of Nephrology, 2020)ENGLISH ABSTRACT: Hypertension is a global health issue of paramount importance, which has not spared the African continent where an unacceptably high prevalence of uncontrolled blood pressure prevails among its population. ... -
Optimising influenza vaccination during a SARS-CoV-2 epidemic in South Africa could help maintain the integrity of our healthcare system
(Health & Medical Publishing Group, 2020)ENGLISH ABSTRACT: The novel infectious disease coronavirus disease 2019 (COVID-19), first reported in late December 2019 in Wuhan, China, seems increasingly unlikely to be contained, resulting in the first pandemic of ... -
Benefit v. risk when using chloroquine in patients with severe COVID-19 disease
(Health & Medical Publishing Group, 2020-04-02)ENGLISH ABSTRACT: Chloroquine (CQ) is widely advocated as treatment for coronavirus disease 2019 (COVID-19), including the president of the USA publicly supporting the use of hydroxychloroquine (HCQ) as a ‘game-changer’ ... -
Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics
(Nature Research, 2018-07-09)Glioblastoma Multiforme (GBM) is known to be one of the most malignant and aggressive forms of brain cancer due to its resistance to chemotherapy. Recently, GBM was found to not only utilise both oxidative phosphorylation ... -
Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson’s Disease, Alzheimer’s Disease and Type 2 Diabetes Mellitus
(Nature Research, 2018-11-14)Many chronic diseases, including those classified as cardiovascular, neurodegenerative, or autoimmune, are characterized by persistent inflammation. The origin of this inflammation is mostly unclear, but it is typically ... -
Evaluation of locally manufactured patient-specific custom made implants for cranial defects using a silicone mould
(Health and Medical Publishing Group, 2018)Background: Cranial vault defects can pose a significant problem for neurosurgeons where autologous bone is no longer available for cranioplasty. Numerous materials exist to create implants which include polymethyl ... -
B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients
(Medpharm Publications, 2018)Background: Altered immune mechanisms play a critical role in the pathogenesis of non-Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive T-cell activation, which can lead to increased ... -
Reconceptualising health professions education in South Africa
(Academy of Science of South Africa, 2018)No abstract available. -
How good are our guidelines? Four years of experience with the SAMJ’s AGREE II review of submitted clinical practice guideline
(Health & Medical Publishing Group, 2018)The South African Medical Journal (SAMJ) is an established source of clinical practice guidelines (CPGs) serving the local healthcare community. CPGs link professional societies and clinicians by guiding best practice ... -
Effect of exogenous surfactant on Paediatric Bronchoalveolar lavage derived macrophages’ cytokine secretion
(BMC (part of Springer Nature), 2019-12-05)Background: Bronchoalveolar lavage is a useful bronchoscopy technique. However, studies in “normal” children populations are few. Furthermore, the anti-inflammatory effects of exogenous pulmonary surfactants on ... -
Contemporary best practice in the management of malignant pleural effusion
(SAGE Publications, 2018)ENGLISH ABSTRACT: Malignant pleural effusion (MPE) affects more than 1 million people globally. There is a dearth of evidence on the therapeutic approach to MPE, and not surprisingly a high degree of variability in the ... -
Pattern of renal amyloidosis in South Africa
(BMC (part of Springer Nature), 2019-11-09)Background: Kidney disease is a serious manifestation of systemic amyloidosis and a major cause of morbidity and mortality. Tuberculosis (TB) occurs up to 27 times more commonly in human immunodeficiency virus (HIV) ... -
Salivary creatinine as a diagnostic tool for evaluating patients with chronic kidney disease
(BMC (part of Springer Nature), 2019-10-29)Background: Preliminary studies have shown the potential use of salivary creatinine concentration in the diagnosis of chronic kidney disease (CKD). For saliva to replace serum as a diagnostic tool, studies must be done ... -
Clinical and pathological features of acral melanoma in a South African population : a retrospective study
(Health & Medical Publishing Group, 2018-08-28)Background. Acral melanoma (AM) is a rare subtype of cutaneous melanoma (CM) that disproportionately affects skin of colour and carries a poorer prognosis than other melanoma subtypes. The poor prognosis is attributed to ... -
Chronic coronary syndromes - time to reassess the evidence
(South African Heart Association, 2018)No abstract available. -
The left atrial appendage - a design flaw or an essential structure
(South African Heart Association, 2018)ENGLISH ABSTRACT: The left atrial appendage (LAA) is considered to be a vestigial remnant of the primitive foetal atrium. It has also been identified as the source of the majority of left atrial thrombi in nonvalvular ... -
An unusual cause for a dilated right heart 33-years post-surgical repair of aortic coarctation
(South African Heart Association, 2018)Prior to planning for the surgical correction of a congenital cardiac defect it is of the utmost importance that additional defects, which themselves might also require surgical correction, be sought and identified. Of ...
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