Department of Medicine
Sub-communities within this community
Recent Submissions
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Aberrant apoptotic response of colorectal cancer cells to novel nucleoside analogues
(Public Library of Science, 2015)Despite the increased understanding of colorectal cancer and the introduction of targeted drug therapy, the metastatic phase of the disease remains refractory to treatment. Since the deregulation of normal apoptosis ...
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Application of Caco-2 cell line in herb-drug interaction studies : current approaches and challenges
(Canadian Society for Pharmaceutical Sciences, 2014-01)The Caco-2 model is employed in pre-clinical investigations to predict the likely gastrointestinal permeability of drugs because it expresses cytochrome P450 enzymes, transporters, microvilli and enterocytes of identical ...
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Biomarkers of HIV-associated cancer
(Libertas Academica, 2014)Cancer biomarkers have provided great opportunities for improving the management of cancer patients by enhancing the efficiency of early detection, diagnosis, and efficacy of treatment. Every cell type has a unique molecular ...
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Low-Pass filtering approach via empirical mode decomposition improves short-scale entropy-based complexity estimation of QT interval variability in long QT syndrome type 1 patients
(MDPI, 2014-09-05)Entropy-based complexity of cardiovascular variability at short time scales is largely dependent on the noise and/or action of neural circuits operating at high frequencies. This study proposes a technique for canceling ...
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Validation of a severity-of-illness score in patients with tuberculosis requiring intensive care unit admission
(Health & Medical Publication Group, 2015-05-27)Background. There is a paucity of data on the determinants of mortality due to tuberculosis (TB) in the intensive care unit (ICU). Objective. To develop a simple severity-of-illness score for use in patients with TB admitted ...
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Inhibitory effect of selected herbal supplements on CYP450-mediated metabolism : an in vitro approach
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: INTRODUCTION Herbal products are popularly used as complementary and alternative medicines to treat a variety of conditions. Often patients use them in conjunction with conventional medicines. Herbal ...
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The role of Phosphodiesterase (PDE3) in heart protection.
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction: During a heart attack the blood supply to the heart is reduced significantly, known as ischemia (Reimer & Jennings, 1991). Energy generating pathways that require oxygen become inhibited in ...
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Evaluating a bioprosthetic anterior mitral valve leaflet made from autologous jugular vein and expanded polytetrafluoroethylene (Gore-Tex) chordae in a sheep model
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: The purpose of this study was to evaluate whether an autologous vein graft supported by expanded polytetrafluoroethylene (Gore-Tex) chordae can be used to replace an anterior mitral valve leaflet and ...
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Multiscale complexity analysis of the cardiac control identifies asymptomatic and symptomatic patients in long QT syndrome type 1
(PLoS, 2014-04-04)The study assesses complexity of the cardiac control directed to the sinus node and to ventricles in long QT syndrome type 1 (LQT1) patients with KCNQ1-A341V mutation. Complexity was assessed via refined multiscale entropy ...
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A putative founder effect for Parkinson’s disease in South African Afrikaners
(Health & Medical Publishing Group, 2014-06)There is evidence for a founder effect for Parkinson’s disease in South African Afrikaners. This finding is of importance for two reasons. Firstly, given that established genetic causes of PD have not been identified in ...
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Biomarkers of HIV associated malignancies and of drug interaction between anti-retrovirals (ARVs) and chemotherapy
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: INTRODUCTION: Altered immune mechanisms play a critical role in the pathogenesis of Non-Hodgkin lymphoma (NHL), as evidenced by increased rates of NHL among HIV+ patients [De Roos et al., 2012; Mellgren ...
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Aetiopathogenesis of atopic dermatitis
(Health & Medical Publishing Group, 2014-10)The aetiopathogenesis of atopic dermatitis (AD) is complex and during recent years much has been learnt regarding the genetic predisposition to the development of this condition and how its interaction with the environment ...
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Development and usability evaluation of a multimedia e-learning resource for electrolyte and acid-base disorders
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH ABSTRACT: We have developed an innovative multimedia e-learning resource, the Electrolyte Workshop, to provide students and clinicians with instruction and the opportunity for simulated practice in managing ...
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Pharmacokinetic herb-drug interaction study of selected traditional medicines used as complementary and alternative medicine (CAM) for HIV/AIDS
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH ABSTRACT: Introduction The increasing intake of traditional medicines among HIV/AIDS patients in sub-Saharan Africa needs urgent consideration by clinicians and other healthcare providers since the safety of such ...
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A historical perspective of allogeneic and autologous immunohaematopoietic stem cell transplantation in South Africa and a study of the non-haematologic consequences
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH ABSTRACT: HISTORICAL PERSPECTIVE Stem cell therapy was commenced after using rabbits as research models. Once this process was successful, the first human transplant was done in 1974. Certain prerequisites were ...
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Oral versus pulse intravenous cyclophosphamide: a retrospective analysis of adverse events in a high infectious diseases burdened setting
(Stellenbosch : Stellenbosch University, 2014-01-14)ENGLISH ABSTRACT: Background Cyclophosphamide (CPM) is still considered to be the first line treatment of many life-threatening autoimmune conditions. It does however carry significant risk for severe adverse events ...
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Bolus administration of intravenous glucose in the treatment of hyperkalemia : a randomized controlled trial
(Karger, 2014-02)Background: Hyperkalemia is a common medical emergency that may result in serious cardiac arrhythmias. Standard therapy with insulin plus glucose reliably lowers the serum potassium concentration ([K + ]) but carries ...
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Effect of improving the usability of an e-learning resource : a randomized trial
(HighWire, 2014-06)Optimizing the usability of e-learning materials is necessary to reduce extraneous cognitive load and maximize their potential educational impact. However, this is often neglected, especially when time and other resources ...
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South African renal registry annual report 2012
(South African Renal Society, 2012-04)INTRODUCTION: This first report of the new South African Renal Registry provides data on renal replacement therapy (RRT) for patients with end-stage renal disease (ESRD) in South Africa. Our previous registry, the ...
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The effect of highly active antiretroviral therapy on Human Papilloma Virus Infection and Cervical Dysplasia in women living with HIV
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Title The Effect of Highly Active Antiretroviral Therapy on Human Papilloma Virus Infection and Cervical Cytological Abnormalities in Women Living With HIV Background Human Papillomavirus (HPV) infection ...
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Challenges in biobank governance in Sub-Saharan Africa
(BioMed Central, 2013-09)Background: Biological sample and data transfer within and out of Africa is steeped in controversy With the H3Africa project now aiming to establish biobanks in Africa, it is essential that there are ethical and ...
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Discourse of final-year medical students during clinical case presentations
(Health and Medical Publishing Group (HMPG), 2011-06)Introduction: The need for medical students to adopt a discourse appropriate to the field is repeatedly emphasised by teaching staff during lectures and ward rounds. The acquisition of such discourse is often not assessed, ...
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Guideline on the management of psoriasis in South Africa
(Health and Medical Publishing Group (HMPG), 2010-04)Background. Psoriasis vulgaris is a chronic, relapsing, immunemediated, potentially devastating disease, influenced by genetic and environmental factors, that can cause substantial morbidity and psychological stress and ...
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Surfactant treatment before first breath for respiratory distress syndrome in preterm lambs : comparison of a peptide-containing synthetic lung surfactant with porcine-derived surfactant
(Dovepress, 2013-08)Background: In a recent study utilizing a saline-lavaged adult rabbit model, we described a significant improvement in systemic oxygenation and pulmonary shunt after the instillation of a novel synthetic peptide-containing ...
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Adenocarcinoma the most common cell type in patients presenting with primary lung cancer in the Western Cape
(Health and Medical Publishing Group (HMPG), 2011-05)Lung cancer is the most common cause of cancer-related mortality worldwide for men and women, causing approximately 1.2 million deaths per year. The absolute and relative frequencies of lung cancer have risen dramatically ...
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The pharmacokinetics of enteral antituberculosis drugs in patients requiring intensive care
(Health and Medical Publishing Group (HMPG), 2013-06)Background. There is a paucity of data on the pharmacokinetics of fixed-dose combination enteral antituberculosis treatment in critically ill patients. Objectives. To establish the pharmacokinetic profile of a fixed-dose ...
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Pharmacokinetics of twice-daily versus once-daily dosing with granular slow-release para-aminosalicylic acid in adults on second-line anti-tuberculosis and antiretroviral treatment
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Background: Para-aminosalicylic acid (PAS) is one of the first effective anti-tuberculosis agents and has become one of the principal second-line drugs to treat patients with an extended resistance spectrum. ...
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In vitro assessment of some traditional medications used in South Africa for pharmacokinetics drug interaction potential
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Introduction Earlier studies have shown the popularity of herbal products among people as traditional, complementary or alternative medication. One of the major clinical risks in the concomitant administration ...
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Advancing research ethics training in Southern Africa (ARESA)
(Health and Medical Publishing Group (HMPG), 2012-12)Southern Africa is a research-rich environment in which research ethics review is critical. The research ethics review system is well established but considerable variability in capacity and training exists among the various ...
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Snake bites, spider bites and scorpion stings
(Health and Medical Publications Group (HMPG), 2012-10)Exposure of humans to natural toxins occurs via snake bites, spider bites and scorpion stings, or by plant or mushroom poisonings. According to the WHO (http://www.who.int/neglected_diseases/ diseases/snakebites/en/), ...
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