High-dose immunoglobulin therapy in four patients with onyalai
Date
1991
Authors
Hesseling P.B.
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Abstract
Onyalai, a form of immune thrombocytopenia in Africa, has a recorded death rate of 9.8% in the acute phase due to haemorrhagic shock or central nervous system bleeding. Four patients with active bleeding and a mean platelet count of 6 x 109/litre were each treated with 0.67 g/kg intravenous globulin (Sandoglobulin®) daily on 3 successive days. Clinical bleeding ceased within 3 d and all patients responded with a rise in the platelet count, which peaked at 19-21 d. No side effect was recorded. Intravenous globulin therapy may reduce the morbidity of the acute phase of onyalai.
Description
Keywords
immunoglobulin, immunoglobulin g, adolescent, adult, article, female, human, human experiment, intravenous drug administration, male, priority journal, thrombocytopenia, Adolescent, Adult, Aged, Case Report, Child, Female, Human, Immunization, Passive, Immunoglobulin G, Immunoglobulins, Intravenous, Infusions, Intravenous, Male, Platelet Count, Purpura, Thrombocytopenic
Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene
85
1
85
1