Oestrogen supplementation in gamete intrafallopian transfer (GIFT) - A prospective randomised study
Date
2005
Authors
de Decker A.P.H.
Kruger T.F.
Siebert T.I.
van der Merwe J.P.
Lombard C.J.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objective. To investigate the impact of oestrogen supplementation from the early luteal to the late proliferative phase on biochemical and ongoing pregnancy rates in gamete intrallopian transfer [GIFT]. Methods. Ninety-five patients were assigned to clomiphene citrate-human menopausal gonadotrophin (hMG)-induced GIFT cycles, with or without the use of oestrogen support (oral administration of estradiol valerate). The main outcome measure were biochemical pregnancy rate and clinical pregnancy rate. Results. The biochemical pregnancy rate was 38.09% in the oestrogen group v. 22.9% in the control group (p = 0.096, 96% CI: 5.7 - 37.3%). The clinical pregnancy rate in the oestrogen supplementation group was 23.8% v. 14.58% in the control group (p = 0.1988, 95% CI: 10.3 - 31.7%. Conclusion. Although the results of this study shows no significant difference, there is a clinical trend in favour of giving oestrogen support.
Description
Keywords
chorionic gonadotropin, clomifene citrate, estradiol valerate, follitropin, human menopausal gonadotropin, luteinizing hormone, perganol, progesterone, adult, article, biochemistry, clinical trial, confidence interval, controlled clinical trial, controlled study, drug response, female, female infertility, gamete intrafallopian transfer, human, luteal phase, major clinical study, oocyte maturation, pregnancy rate, prospective study, randomized controlled trial, statistical analysis, statistical significance, treatment indication
Citation
South African Journal of Obstetrics and Gynaecology
11
1
11
1