Cavitating pulmonary tuberculosis in children: Correlating radiology with pathogenesis

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Show simple item record Griffith-Richards S.B. Goussard P. Andronikou S. Gie R.P. Przybojewski S.J. Strachan M. Vadachia Y. Kathan D.L. 2011-05-15T16:17:41Z 2011-05-15T16:17:41Z 2007
dc.identifier.citation Pediatric Radiology
dc.identifier.citation 37
dc.identifier.citation 8
dc.identifier.issn 03010449
dc.identifier.other 10.1007/s00247-007-0496-z
dc.description.abstract Background: Cavitating pulmonary tuberculosis (PTB) is generally known as a disease of adults, with children typically having features of primary PTB. Objective: To group children with PTB and cavities according to possible pathogenesis by evaluating the clinical and radiological findings. Materials and methods: The clinical and radiological findings in ten randomly selected children with PTB and cavitations on chest radiographs were retrospectively reviewed and evaluated. Results: Three groups emerged: group 1 (four children) had cavities, usually single and unilateral in the classic upper lobe distribution of postprimary PTB; group 2 (three children) developed progressive primary spread of disease with extensive and bilateral pulmonary cavities; and group 3 (three children) developed cavities secondary to airway obstruction by mediastinal lymph nodes with consequent distal collapse and consolidation. Children in group 1 responded well to treatment and had unremarkable recoveries. Children in group 2 were all below 2 years of age with complicated recoveries. Children in group 3 had frequent complications resulting in one fatality. Conclusion: Cavities in PTB inchildren may arise by one of three possible mechanisms with a relatively equal incidence. A study is underway to determine the incidence of cavity formation associated with mediastinal lymphadenopathy and airway obstruction. © Springer-Verlag 2007.
dc.subject antibiotic agent
dc.subject adolescent
dc.subject antibiotic resistance
dc.subject article
dc.subject bacterium culture
dc.subject child
dc.subject childhood disease
dc.subject childhood mortality
dc.subject clinical article
dc.subject clinical assessment
dc.subject clinical feature
dc.subject computer assisted tomography
dc.subject controlled study
dc.subject disease classification
dc.subject female
dc.subject human
dc.subject incidence
dc.subject infant
dc.subject lung tuberculosis
dc.subject lymphadenopathy
dc.subject male
dc.subject mediastinum lymph node
dc.subject Mycobacterium tuberculosis
dc.subject nonhuman
dc.subject outcome assessment
dc.subject pathogenesis
dc.subject priority journal
dc.subject retrospective study
dc.subject thorax radiography
dc.subject Adolescent
dc.subject Child
dc.subject Child, Preschool
dc.subject Diagnosis, Differential
dc.subject Female
dc.subject Humans
dc.subject Infant
dc.subject Male
dc.subject Retrospective Studies
dc.subject Tomography, X-Ray Computed
dc.subject Tuberculosis, Pulmonary
dc.title Cavitating pulmonary tuberculosis in children: Correlating radiology with pathogenesis
dc.type Article
dc.description.version Article
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