Tremor in Parkinson's disease
Date
2002
Authors
Carr J.
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Abstract
Rest tremor is a common feature of Parkinson's disease, but its underlying pathophysiology remains unknown. This review hypothesizes that tremor is related to selective loss of components of the substantia nigra. The relative scarcity of tremor in related Parkinsonian conditions may indicate a dissociation associated with different pathological involvement of the substantia nigra and its connections. Connections of the subthalamic nucleus with the pallidum, modified by cortical and nigral inputs, allow for the transfer of tremorogenic activity to the thalamus. Thalamo-cortical interactions, tempered by cerebellar input, generate the final common pathway for tremor production. © 2002 Elsevier Science Ltd. All rights reserved.
Description
Keywords
clinical feature, globus pallidus, human, Parkinson disease, pathophysiology, priority journal, review, substantia nigra, subthalamic nucleus, thalamocortical tract, thalamus, tremor, Animals, Cerebral Cortex, Humans, Models, Neurological, Parkinson Disease, Substantia Nigra, Thalamus, Tremor
Citation
Parkinsonism and Related Disorders
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