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The effect of partial noradrenergic denervation on corticosterone secretion in the rat

dc.contributor.authorDaniels W.M.U.
dc.contributor.authorJaffer A.
dc.contributor.authorSearson A.
dc.contributor.authorRussell V.A.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:28Z
dc.date.available2011-05-15T16:17:28Z
dc.date.issued1989
dc.identifier.citationNeurochemical Research
dc.identifier.citation14
dc.identifier.citation12
dc.identifier.issn03643190
dc.identifier.urihttp://hdl.handle.net/10019.1/14228
dc.description.abstractDSP4 (N-(-2-chloroethyl)-N-ethyl-2-bromobenzylamine) treatment significantly decreased the noradrenaline content in the hippocampus, frontal cortex and hypothalamus of the rat brain. DSP4 treatment did not affect plasma corticosterone levels. Clonidine, an α2-adrenoceptor agonist, had no effect on corticosterone secretion in either DSP4- or saline-treated rats. Isoproterenol, a β-adrenoceptor agonist, significantly stimulated corticosterone secretion. This effect was inhibited by the prior administration of the β-adrenoceptor antagonist propranalol. DSP4 treatment did not alter the isoproterenol-induced stimulation of corticosterone secretion. The administration of a high dose of dexamethasone (100 μg/kg, i.p.) significantly decreased the plasma corticosterone concentration of saline-treated controls, while an intermediate dose (25 μg/kg, i.p.) did not suppress corticosterone release significantly. DSP4-treatment did not influence dexamethasone-induced suppression of corticosterone secretion. These results show that significant decreases in noradrenaline content in the hippocampus, frontal cortex and hypothalamus appear to have no effect on the regulation of corticosterone secretion and that corticosterone secretion may be stimulated by catecholamines via β-adrenoceptors.
dc.subjectalpha 2 adrenergic receptor
dc.subjectbeta adrenergic receptor
dc.subjectnoradrenalin
dc.subjectanimal experiment
dc.subjectarticle
dc.subjectbrain cortex
dc.subjectcorticosterone release
dc.subjecthippocampus
dc.subjecthypothalamus
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectAdrenergic Fibers
dc.subjectAnimal
dc.subjectBenzylamines
dc.subjectBrain
dc.subjectClonidine
dc.subjectCorticosterone
dc.subjectIsoproterenol
dc.subjectMale
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectSupport, Non-U.S. Gov't
dc.subjectAnimalia
dc.titleThe effect of partial noradrenergic denervation on corticosterone secretion in the rat
dc.typeArticle
dc.description.versionArticle


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