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Lack of effect of bilateral locus coeruleus lesion and antidepressant treatment on gamma-aminobutyric acid(B) receptors in the rat frontal cortex

Lack of effect of bilateral locus coeruleus lesion and antidepressant treatment on gamma-aminobutyric acid(B) receptors in the rat frontal cortex

dc.contributor.authorEngelbrecht A.H.
dc.contributor.authorRussell V.A.
dc.contributor.authorTaljaard J.J.F.
dc.contributor.authorEngelbrecht A.H.
dc.contributor.authorRussell V.A.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:26Z
dc.date.accessioned2011-05-15T16:17:26Z
dc.date.available2011-05-15T16:17:26Z
dc.date.available2011-05-15T16:17:26Z
dc.date.issued1994
dc.date.issued1994
dc.identifier.citationNeurochemical Research
dc.identifier.citation19
dc.identifier.citation9
dc.identifier.citationNeurochemical Research
dc.identifier.citation19
dc.identifier.citation9
dc.identifier.issn03643190
dc.identifier.issn03643190
dc.identifier.urihttp://hdl.handle.net/10019.1/14214
dc.identifier.urihttp://hdl.handle.net/10019.1/14214
dc.description.abstractThe aim of the present study was to investigate whether a disturbance of the central noradrenergic (NA) system could cause changes in gamma- aminobutyric acid(B) (GABA(B)) receptors in the rat frontal cortex. Manipulation of the NA projection to the frontal cortex was achieved by bilateral lesion of the locus coeruleus with 6-hydroxydopamine (6-OHDA) or chronic treatment with the NA reuptake blocker and antidepressant drug, desipramine. Precautions were taken to ensure that the GABA(B) receptor assay was performed optimally and was not confounded by the presence of endogenously generated GABA. The results show conclusively that manipulation of the NA projection did not result in any significant change in the number (Bmax) or affinity (Kd) of GABA(B) receptors in the frontal cortex. These results do not support the hypothesis that hypoactivity of the central NA system can lead to changes in cortical GABA(B) receptors and that antidepressant drugs act by increasing GABA(B) receptor binding in the frontal cortex.
dc.description.abstractThe aim of the present study was to investigate whether a disturbance of the central noradrenergic (NA) system could cause changes in gamma- aminobutyric acid(B) (GABA(B)) receptors in the rat frontal cortex. Manipulation of the NA projection to the frontal cortex was achieved by bilateral lesion of the locus coeruleus with 6-hydroxydopamine (6-OHDA) or chronic treatment with the NA reuptake blocker and antidepressant drug, desipramine. Precautions were taken to ensure that the GABA(B) receptor assay was performed optimally and was not confounded by the presence of endogenously generated GABA. The results show conclusively that manipulation of the NA projection did not result in any significant change in the number (Bmax) or affinity (Kd) of GABA(B) receptors in the frontal cortex. These results do not support the hypothesis that hypoactivity of the central NA system can lead to changes in cortical GABA(B) receptors and that antidepressant drugs act by increasing GABA(B) receptor binding in the frontal cortex.
dc.subjectdesipramine; oxidopamine; animal model; animal tissue; article; controlled study; depression; frontal cortex; locus ceruleus; male; nonhuman; noradrenergic system; priority journal; rat; receptor affinity; receptor binding; receptor density; receptor upregulation; synaptic membrane; Animal; Cryopreservation; Desipramine; Frontal Lobe; Laterality; Locus Coeruleus; Male; Rats; Rats, Wistar; Receptors, GABA-A; Support, Non-U.S. Gov't
dc.subjectdesipramine
dc.subjectoxidopamine
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdepression
dc.subjectfrontal cortex
dc.subjectlocus ceruleus
dc.subjectmale
dc.subjectnonhuman
dc.subjectnoradrenergic system
dc.subjectpriority journal
dc.subjectrat
dc.subjectreceptor affinity
dc.subjectreceptor binding
dc.subjectreceptor density
dc.subjectreceptor upregulation
dc.subjectsynaptic membrane
dc.subjectAnimal
dc.subjectCryopreservation
dc.subjectDesipramine
dc.subjectFrontal Lobe
dc.subjectLaterality
dc.subjectLocus Coeruleus
dc.subjectMale
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, GABA-A
dc.subjectSupport, Non-U.S. Gov't
dc.titleLack of effect of bilateral locus coeruleus lesion and antidepressant treatment on gamma-aminobutyric acid(B) receptors in the rat frontal cortex
dc.titleLack of effect of bilateral locus coeruleus lesion and antidepressant treatment on gamma-aminobutyric acid(B) receptors in the rat frontal cortex
dc.typeArticle
dc.typeArticle
dc.description.versionArticle
dc.description.versionArticle


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