Relative fetal hypoxia as a contributing factor to fetal macrosomia in diabetic pregnancy
Date
1983
Authors
McFarlane C.M.
Tsakalakos N.
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Abstract
It has been shown that the initial increase in fetal size in the macrosomic neonates of diabetic mothers occurs after approximately 26 weeks gestation, and that a further more dramatic increase occurs at approximately 34 weeks until term. It is proposed that the initial increase is caused by fetal hyperinsulinism (Pedersen Hypothesis), and that the latter increase results from an induced relative fetal hypoxia. It is suggested that the mechanism responsible for the latter increase in fetal size is an increase in the amount of fetal glucose which is metabolized through the hexose monophosphate shunt pathway.
Description
Keywords
congenital disorder, diabetes mellitus, endocrine system, etiology, fetus, fetus growth, fetus hypoxia, gigantism, high birth weight, human, hyperinsulinism, hypoxia, maternal disease, pregnancy, Adolescent, Adult, Birth Weight, Female, Fetal Anoxia, Fetal Diseases, Fetus, Gestational Age, Glucose, Growth, Human, Hyperglycemia, Hyperinsulinism, Maternal-Fetal Exchange, Models, Biological, Pregnancy, Pregnancy in Diabetics
Citation
Medical Hypotheses
11
3
11
3