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Safety of pleurodesis with talc poudrage in malignant pleural effusion: a prospective cohort study

dc.contributor.authorJanssen J.P.
dc.contributor.authorCollier G.
dc.contributor.authorAstoul P.
dc.contributor.authorTassi G.F.
dc.contributor.authorNoppen M.
dc.contributor.authorRodriguez-Panadero F.
dc.contributor.authorLoddenkemper R.
dc.contributor.authorHerth F.J.
dc.contributor.authorGasparini S.
dc.contributor.authorMarquette C.H.
dc.contributor.authorBecke B.
dc.contributor.authorFroudarakis M.E.
dc.contributor.authorDriesen P.
dc.contributor.authorBolliger C.T.
dc.contributor.authorTschopp J.-M.
dc.date.accessioned2011-05-15T16:17:18Z
dc.date.available2011-05-15T16:17:18Z
dc.date.issued2007
dc.identifier.citationLancet
dc.identifier.citation369
dc.identifier.citation9572
dc.identifier.issn01406736
dc.identifier.other10.1016/S0140-6736(07)60708-9
dc.identifier.urihttp://hdl.handle.net/10019.1/14156
dc.description.abstractBackground: Talc is the most effective chemical pleurodesis agent for patients with malignant pleural effusion. However, concerns have arisen about the safety of intrapleural application of talc, after reports of development of acute respiratory distress syndrome in 1-9% of treated patients. Our aim was to establish whether use of large-particle-size talc is safe in patients with malignant pleural effusion. Methods: We did a multicentre, open-label, prospective cohort study of 558 patients with malignant pleural effusion who underwent thoracoscopy and talc poudrage with 4 g of calibrated French large-particle talc in 13 European hospitals, and one in South Africa. The primary endpoint was the occurrence of acute respiratory distress syndrome after talc pleurodesis. Findings: No patients developed acute respiratory distress syndrome (frequency 0%, one-sided 95% CI 0-0·54%). 11 (2%) patients died within 30 days. Additionally, seven patients had non-fatal post-thoracoscopy complications (1·2%), including one case of respiratory failure due to unexplained bilateral pneumothorax. Interpretation: Use of large-particle talc for pleurodesis in malignant pleural effusion is safe, and not associated with the development of acute respiratory distress syndrome. © 2007 Elsevier Ltd. All rights reserved.
dc.subjectantibiotic agent
dc.subjectdiuretic agent
dc.subjecttalc
dc.subjectadult
dc.subjectadult respiratory distress syndrome
dc.subjectaged
dc.subjectarticle
dc.subjectclinical trial
dc.subjectcohort analysis
dc.subjectcongestive heart failure
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdisease course
dc.subjectfemale
dc.subjectfever
dc.subjecthuman
dc.subjecthypoxemia
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality
dc.subjectmulticenter study
dc.subjectpericardial effusion
dc.subjectpleura biopsy
dc.subjectpleura effusion
dc.subjectpleurodesis
dc.subjectpneumothorax
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectrecurrent disease
dc.subjectrespiratory failure
dc.subjectSouth Africa
dc.subjectthoracoscopy
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectParticle Size
dc.subjectPleural Effusion, Malignant
dc.subjectPleurodesis
dc.subjectProspective Studies
dc.subjectRespiratory Distress Syndrome, Adult
dc.subjectSafety
dc.subjectTalc
dc.subjectThoracoscopy
dc.subjectTreatment Outcome
dc.titleSafety of pleurodesis with talc poudrage in malignant pleural effusion: a prospective cohort study
dc.typeArticle
dc.description.versionArticle


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