Comparative contraceptive experience with three month and six month medroxyprogesterone acetate regimens
Date
1977
Authors
Rall H.J.S.
Van Niekerk W.A.
Engelbrecht andVan Schalkwyk B.H.J.D.J.
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Journal ISSN
Volume Title
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Abstract
Three month (150 mg) and six month (450 mg) contraceptive regimens of medroxyprogesterone acetate (DMPA) as an intramuscular depot injection are compared in this paper. A total of 19,875 women participated in the study, accounting for 220,530 woman months of use. A Pearl index of 0.1069 for the three month regimen was significantly lower than for the six month group, where the index was 0.4943 (p <0.01). Side effects were limited insofar as personal reasons and loss to follow up were the most important single category for discontinuation of this contraceptive method. No thrombotic incidents occurred. Is is concluded that both contraceptive regimens of DMPA appear to be acceptable with regard to use effectiveness, patient acceptance and prevalence of side effects.
Description
Keywords
contraceptive agent, medroxyprogesterone acetate, progesterone, contraception, drug screening, human, intramuscular drug administration, normal human, pregnancy, Adolescent, Adult, Comparative Study, Female, Follow-Up Studies, Human, Injections, Intramuscular, Medroxyprogesterone, Middle Age, Ovulation, Parity, Pregnancy, Time Factors, Vaginal Smears
Citation
Journal of Reproductive Medicine for the Obstetrician and Gynecologist
18
2
18
2