Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting
Date
2008
Authors
Cotton M.F.
Schaaf H.S.
Lottering G.
Weber H.L.
Coetzee J.
Nachman S.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Exposure to TB was quantified by screening human immunodeficiency virus (HIV) exposed infants aged 3-4 months for an isoniazid prophylaxis study where tuberculosis (TB) exposure excluded enrolment. Seventy-seven (10.1%, 95%CI 8.0-12.4) of 766 infants had contact with a TB source case. Nurses and lay counsellors identified 52 infants during pre-screening and doctors identified 25 during formal screening. High exposure may contribute to high rates of TB in HIV-exposed infants. Programs to prevent mother-to-child transmission of HIV offer an important opportunity to screen for TB. In-depth assessment is required for evaluating TB exposure. © 2008 The Union.
Description
Keywords
isoniazid, rifampicin, article, female, human, Human immunodeficiency virus, Human immunodeficiency virus infection, incidence, infant, major clinical study, male, mother child relation, prevalence, priority journal, prophylaxis, screening, treatment outcome, tuberculosis, Adult, Disease Transmission, Vertical, Female, HIV Infections, Humans, Infant, Mass Screening, Maternal Health Services, Pregnancy, Pregnancy Complications, Infectious, Prevalence, South Africa, Tuberculosis, Pulmonary
Citation
International Journal of Tuberculosis and Lung Disease
12
2
12
2