Medical Physiology
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Ataxia-Telangiectasia Mutated is located in cardiac mitochondria and impacts oxidative phosphorylation
(Springer Nature, 2019)The absence of Ataxia-Telangiectasia mutated protein kinase (ATM) is associated with neurological, metabolic and cardiovascular defects. The protein has been associated with mitochondria and its absence results in mitochondrial ... -
The effect of lipid modifying drugs on male reproductive parameters
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: The risk of cardiovascular disease (CVD) is prevalent and on the increase globally. Lipid-lowering drugs, have been found to reduce CVD. They act by either reducing LDL or increasing HDL. Thus reducing ... -
An investigation into the role of ATM protein in mitochondrial defects associated with cardiovascular pathology resulting from insulin resistance
(Stellenbosch : Stellenbosch University, 2019-04)Background: Ataxia-telangiectasia (A-T) is a rare, recessive disorder that develops in the absence of Ataxia-Telangiectasia Mutated protein kinase (ATM). This complex disease is characterised by neurodegeneration, increased ... -
Quantification of positron emission tomography brain imaging using 18F-Fallypride: a simulation
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: 18F-fallypride is of interest in neurological and psychiatric diseases to visualise dopamine D2/D3 receptors in striatal and extrastriatal regions. Several simplified methods of quantifying positron ... -
ATM Expression in peripheral blood mononuclear cells as a biomarker of insulin resistance
(Stellenbosch : Stellenbosch University, 2019-04)Introduction: The Ataxia Telangiectasia Mutated (ATM) gene codes for the 350 kDa ATM protein kinase. ATM gene mutations cause inactivity/deficiency of the ATM protein, resulting in the autosomal recessive disease Ataxia ... -
Investigating the onset of insulin resistance and non-alcoholic fatty liver disease in obesity-induced cardiac dysfunction
(Stellenbosch : Stellenbosch University, 2019-04)Introduction: The global obesity epidemic has been associated with various metabolic disorders, including insulin resistance and non-alcoholic fatty liver disease (NAFLD). Insulin resistance is thought be a hallmark of ... -
The Effects of HIV-1-proteins and Antiretroviral Therapy on Aortic Endothelial Cells (AECs) – A Mechanistic in vitro Approach
(Stellenbosch : Stellenbosch University, 2019-04)Introduction: Endothelial dysfunction is an early precursor of cardiovascular disease characterized by decreased nitric oxide (NO) levels following the development of oxidative stress. Oxidative stress has been shown to ... -
In vitro assessment of aspalathin-enriched Rooibos (Aspalathus linearis) extract treatment in statin-induced hepatotoxicity
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: Rooibos (Aspalathus linearis) has been shown to have various health benefits including antidiabetic, lipid-lowering, and hepatoprotective properties. Although anecdotally Rooibos consumption is regarded ... -
Cardioprotective potential of N-acetyl cysteine against hyperglycaemia-induced oxidative damage : a protocol for a systematic review
(BMC (part of Springer Nature), 2017)Background: Hyperglycaemia-induced oxidative damage is a well-established factor implicated in the development of diabetic cardiomyopathy (DCM) in diabetic individuals. Some of the well-known characteristics of DCM ... -
Treatment with a fixed dose combination antiretroviral therapy drug containing tenofovir, emtricitabine and efavirenz is associated with cardioprotection in high calorie diet-induced obese rats
(Public Library of Science, 2018-12-05)HIV-infection, certain antiretroviral drug classes, especially protease inhibitors (PI), and obesity are associated with increased ischaemic heart disease (IHD) risk. However, the effect of PI-free fixed dose combination ... -
Xpert MTB/RIF assay shows faster clearance of Mycobacterium tuberculosis DNA with higher levels of rifapentine exposure
(American Society for Microbiology, 2016-12)The Xpert MTB/RIF assay is both sensitive and specific as a diagnostic test. Xpert also reports quantitative output in cycle threshold (CT ) values, which may provide a dynamic measure of sputum bacillary burden when used ... -
Toxicity associated with tuberculosis chemotherapy in the REMoxTB study
(BioMed Central, 2018-07-11)Background: The incidence and severity of tuberculosis chemotherapy toxicity is poorly characterised. We used data available from patients in the REMoxTB trial to provide an assessment of the risks associated with the ... -
Investigating the modulating effects of Afriplex GRT Extract on vascular function and antioxidant status in obese Wistar rat
(Stellenbosch : Stellenbosch University, 2018-03)Introduction Obesity is associated with the development of metabolic syndrome, a conglomerate of cardiometabolic risk factors, which synergistically result in cardiovascular diseases (CVDs), the major leading cause of ... -
The effects of melatonin supplementation on vascular tissue during first line ART: an in vivo, ex vivo and in vitro study
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: Although Antiretroviral therapy (ART) has dramatically reduced HIVassociated morbidity and mortality, non-HIV-related conditions and comorbidities continue to rise in this population. Cardiovascular disease ... -
The effect of hypoxia on protein phosphatase 2A (PP2A) in MDA-MB-231 cells, and, a pilot study to establish a primary breast cancer cell model from Fine Needle Aspirations.
(Stellenbosch : Stellenbosch University, 2018-03)Background: Cancerous tumours are characterised by areas of insufficient blood supply, with resulting hypoxia and nutrient deprivation. The mechanisms by which cancer cells adapt to these conditions are of interest due ... -
The Significance of Mitophagy in Myocardial Ischaemia/ Reperfusion: the effect of melatonin
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: Myocardial ischaemia and concomitant cell damage are caused by a reduction in the blood supply to the heart. To date, the most effective strategy to salvage the myocardium is timely reperfusion which is ... -
Basic semen parameters assisted by Computer-Aided sperm analysis (CASA) and their correlations with advanced semen parameters in normozoospermic men with different abstinence periods
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: Affordable basic semen analysis remains a fundamental procedure to be performed routinely during the diagnosis of male infertility. Advanced semen analyses, provide valuable clinical insights in treatment ... -
Short abstinence: Impact on the seminal plasma proteome and accessory sex gland secretions
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Various studies have sought to determine the typical versus optimal abstinence period after which semen samples should be collected, and many have been found to be contradictory. Several factors influence ... -
The effect of chronic ingestion of afriplex grt™ on myocardial insulin resistance and mitochondrial function – a preclinical study.
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: Obesity is an excessive fat accumulation in the body, known to be a significant precursor to insulin resistance and type 2 diabetes. Complications associated with obesity can contribute to the development of ... -
Aspalathin reverts doxorubicin-induced cardiotoxicity through increased autophagy and decreased expression of p53/mTOR/p62 signaling
(MDPI, 2017-11-01)ENGLISH ABSTRACT: Doxorubicin (Dox) is an effective chemotherapeutic agent used in the treatment of various cancers. Its clinical use is often limited due to its potentially fatal cardiotoxic side effect. Increasing evidence ...
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