• Nitric oxide and the endothelium : characterisation of in vitro nitric oxide detection techniques and an ex vivo method of measuring endothelial function 

  Loubser, Dirk Jacobus (Stellenbosch : Stellenbosch University, 2014-04)

  ENGLISH ABSTRACT: Introduction: Nitric oxide (NO) is an important chemical messenger in the cardiovascular system. Despite considerable progress in this field, there remains an on-going need for affordable and user-friendly ...
• Identifying appropriate attachment factors for isolated adult rat cardiomyocyte culture and experimentation 

  Lumkwana, Dumisile (Stellenbosch : Stellenbosch University, 2014-04)

  ENGLISH ABSTRACT: Introduction: Primary culture of isolated adult rat cardiomyocytes (ARCMs) is an important model for cardiovascular research, but successful maintenance of these cells in culture for their use in experiments ...
• The role of Protein Phosphatase 2A (PP2A) in myocardial ischaemia/reperfusion injury 

  Van Vuuren, Derick (Stellenbosch : Stellenbosch University, 2014-04)

  ENGLISH ABSTRACT: Ischaemic heart disease is a major contributor to global morbidity and mortality rates. Manoeuvres such as ischaemic preconditioning confer cardioprotection against ischaemia/reperfusion (I/R) injury ...
• The role of melatonin in cardioprotection : an investigation into the mechanisms involved in glucose homeostasis, microvascular endothelial function and mitochondrial function in normal and insulin resistant states 

  Nduhirabandi, Frederic (Stellenbosch : Stellenbosch University, 2014-04)

  ENGLISH ABSTRACT: Introduction: The cardioprotective actions of the hormone melatonin against myocardial ischaemiareperfusion injury (IRI) are well-established. It has recently been shown to prevent the harmful effects ...
• Exposure of cardiac microvascular endothelial cells to harmful stimuli : a study of the cellular responses and mechanisms 

  Genis, Amanda (Stellenbosch : Stellenbosch University, 2014-04)

  ENGLISH ABSTRACT: Exposure to harmful stimuli can render vascular endothelial cells dysfunctional, characterised by reduced nitric oxide (NO) bioavailibility. Endothelial dysfunction (ED) is a reversible precursor ...
• Proteomic analysis of seminal fluid from men exhibiting oxidative stress 

  Sharma, Rakesh   Agarwal, Ashok   Mohanty, Gayatri   Du Plessis, Stefan S.   Gopalan, Banu   Willard, Belinda   Yadav, Satya P.   Sabanegh, Edmund (BioMed Central, 2013-09)

  ABSTRACT: Background: Seminal plasma serves as a natural reservoir of antioxidants. It helps to remove excessive formation of reactive oxygen species (ROS) and consequently, reduce oxidative stress. Proteomic profiling of ...
• Gender selection: separation techniques for X- and Y-chromosome bearing human spermatozoa 

  Van Der Linde, Michelle (Stellenbosch : Stellenbosch University, 2013-12)

  ENGLISH ABSTRACT: Preconceptual sex selection is an ethically justifiable process whereby X- and Y-chromosome bearing spermatozoa are isolated prior to fertilization of the oocyte in order to generate either a male or a ...
• Investigating the effects of nicotine on the male reproductive system 

  Maartens, Pieter Johann (Stellenbosch : Stellenbosch University, 2013-12)

  ENGLISH ABSTRACT: Much has been documented about the detrimental effects of adverse lifestyle factor exposure on the body. Exposure to factors, such as cigarette smoke, have proved to not only be a burden on global health ...
• Ischaemic preconditioning : an investigation of the patterns of kinase activation and protein expression profiles during reperfusion in the rat heart 

  Hattingh, Susanna Maria (Suzel) (Stellenbosch : Stellenbosch University, 2013-12)

  ENGLISH ABSTRACT: Introduction: Coronary heart disease (CHD) is the leading cause of death worldwide with 3.8 million men and 3.4 million women dying globally each year. Although existing myocardial reperfusion strategies ...
• Proteomic analysis of human spermatozoa proteins with oxidative stress 

  Sharma, Rakesh   Agarwal, Ashok   Mohanty, Gayatri   Hamada, Alaa J.   Gopalan, Banu   Willard, Belinda   Yadav, Satya   Du Plessis, Stefan (BioMed Central, 2013-05)

  Background: Oxidative stress plays a key role in the etiology of male infertility. Significant alterations in the sperm proteome are associated with poor semen quality. The aim of the present study was to examine if elevated ...
• A critical analysis of mitochondrial functioning and associated proteins in obesity-related cardiomyopathy 

  George, Siddiqah (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: INTRODUCTION: The mechanism behind obesity-related cardiomyopathies is at present not completely known, however, cardiac insulin resistance has been implicated as one of the main arbitrators of obesity-related ...
• Utilization of antigen-specific host responses in the evaluation of Mycobacterium tuberculosis infection, development of disease and treatment effect 

  Menezes, Angela Maria (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: Setting This study was conducted in the Tygerberg district, Cape Town, in the Western Cape, South Africa Background The evaluation of early tuberculosis (TB) treatment response is based on month 2 ...
• An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet 

  Rengan, A. K.   Agarwal, A.   van der Linde, M.   du Plessis, S. S. (BioMed Cenral, 2012-11-17)

  Recent studies have shown cytoplasmic droplets to be normal morphological occurrences in human male spermatozoa. When the cytoplasm around the sperm midpiece is present in large amounts, however, pathological effects may ...
• Violence against women : impact on reproductive health and pregnancy outcome 

  Schoeman, Jeanne (Stellenbosch : Stellenbosch University, 2003-03)

  ENGLISH ABSTRACT: Introduction Worldwide, up to 25% of women are assaulted during pregnancy, with estimates varying between populations. Violence has been associated with adverse pregnancy outcome, including preterm ...
• A study of the intracellular signalling events involved in the zona pellucida-induced acrosome reaction in human spermatozoa 

  Du Plessis, S. S.(Simon Stephanus) (Stellenbosch : Stellenbosch University, 2002-12)

  ENGLISH ABSTRACT: In this study the author presents new data that will shed light on the fairly nebulous knowledge of intracellular pathways involved in the physiologically induced acrosome reaction and the subsequent ...
• Abnormalities of bone and mineral metabolism in patients with eating disorders 

  Conradie, Maria Martha (Stellenbosch : Stellenbosch University, 2001)

  ENGLISH ABSTRACT: Osteopenia is a well documented complication of anorexia nervosa (AN). The pathogenesis of this bone loss is presently poorly defined in the literature. Pathogenetic mechanisms that have been implicated ...
• Body composition in women with HIV/AIDS : the relevance of exercise 

  Myburgh, Kathryn H.   De Bruto, Petro C. (Health and Medical Publishing Group (HMPG), 2008-07)

  Untreated infection with the human immunodeficiency virus (HIV) leads to severe physical debilitation, culminating in the acquired immune deficiency syndrome (AIDS). Multiple infections, body mass loss, physical weakness ...
• Minimum Information About a Simulation Experiment (MIASE) 

  Waltemath, Dagmar   Adams, Richard (Public Library of Science (PLOS), 2011-04)

  Reproducibility of experiments is a basic requirement for science. Minimum Information (MI) guidelines have proved a helpful means of enabling reuse of existing work in modern biology. The Minimum Information Required in ...
• The role of protein phosphatases in myocardial ischaemia and reperfusion 

  Fan, Wen Jun (Stellenbosch : Stellenbosch University, 2008-03)

  ENGLISH ABSTRACT: Protein kinases and phosphatases play important roles in the phosphorylation state of intracellular proteins under both physiologic and pathophysiologic conditions. Compared to the large number of studies ...
• Creatine and exercise – strong evidence for stronger heart muscle 

  Webster, Ingrid   Huisamen, Barbara   Du Toit, Eugene F. (American Society of Exercise Physiologists, 2011-10)

  There has been a dramatic increase in the use of dietary creatine supplementation among sports men and women, and by clinicians as a therapeutic agent in muscular and neurological diseases. The effects on skeletal muscles ...

View more