Medical Physiology
Collections in this community
Recent Submissions
-
Aspalathin, a C-glucosyldihydrochalcone from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic (db/db) mice
(Institute of Physiology, The Czech Academy of Sciences, 2018-07-25)ENGLISH ABSTRACT: Metformin is the first line therapy of type 2 diabetics, but continued reduction of their life expectancy warrants further investigation into alternative treatment strategies. This study reports on the ... -
Antioxidant activities of Basella alba aqueous leave extract in blood, pancreas, and gonadal tissues of diabetic male Wistar rats
(Wolters Kluwer, 2018)Background: Oxidative stress is frequently identified as a key element in the pathophysiology of many complications of diabetes mellitus, including reproductive complications. The antioxidant potential of medicinal ... -
DNA methylation of FKBP5 in South African women : associations with obesity and insulin resistance
(BMC (part of Springer Nature), 2020-09-21)Background: Disruption of the hypothalamic–pituitary–adrenal (HPA) axis, a neuroendocrine system associated with the stress response, has been hypothesized to contribute to obesity development. This may be mediated through ... -
Vascular function and cardiovascular risk in a HIV infected and HIV free cohort of African ancestry : baseline profile, rationale and methods of the longitudinal EndoAfrica-NWU study
(BioMed Central, 2020-07-03)Background: People living with the Human Immunodeficiency Virus (PLHIV) have an increased susceptibility to develop non-communicable diseases such as cardiovascular disease (CVD). Infection with HIV contributes to the ... -
Investigating the Modulating effects of Fermented Rooibos (Aspalathus linearis) and Fermented Honeybush (Cyclopia intermedia) on aortic endothelial function and antioxidant status in Streptozotocin (STZ) – induced diabetic Wistar rats
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Introduction: Diabetes mellitus is a metabolic disorder that causes chronic hyperglycaemia due to insulin resistance and deficiency. The implications that chronic hyperglycaemia has on vascular function ... -
Epacs exchange protein directly activated by cAMP role in obesity-induced cardiovascular diseases
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Introduction and aims: The strong association between obesity and cardiovascular diseases (CVD) stresses the necessity of elucidating the underlying molecular mechanisms linking these pathologies. ... -
HIV/AIDS and air pollution as emerging cardiovascular risk factors in Cape Town populations : is endothelial function a marker of effect
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Background: HIV and antiretroviral therapy (ART) are associated with cardiovascular disease (CVD). Concomitantly,air pollution is a global health concern and associated with CVD. Although South Africa ... -
The Possible Ameliorating effects of Rooibos, Honeybush and Sutherlandia on diabetes-induced reproductive impairment in adult male Wistar rats
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: The global prevalence of infertility is on the rise, and so is male factor infertility. Out of the approximately 72.4 million infertile couples worldwide, male factor is responsible for 50%. It has ... -
Investigating the ameliorative potential of Aspalathus linearis and Cyclopia intermedia against lipid accumulation, lipolysis, oxidative stress and inflammation
(Stellenbosch : Stellenbosch University, 2020-03)Background Despite the availability of several treatment regimens, obesity continues to be one of the greatest health challenges of the 21st century. In recent years, plant polyphenols have attracted increasing attention ... -
Chronic stress and semen parameters
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: It has been well documented that stress has adverse effects on the body and can lead to various health issues. Stress has been investigated as a cause for unexplained infertility in both men and women. ... -
Highly active antiretroviral therapy alters sperm parameters and testicular antioxidant status in diet-induced obese rats
(Korean Society of Toxicology, 2018)The efficacy of highly active antiretroviral therapy (HAART) has led to an increase demand for therapeutic use, thereby necessitating investigation into drug toxicity. This study was designed to investigate the in vivo ... -
Nutritional support in sepsis : when less may be more
(BMC (part of Springer Nature), 2020-02-14)Despite sound basis to suspect that aggressive and early administration of nutritional support may hold therapeutic benefits during sepsis, recommendations for nutritional support have been somewhat underwhelming. ... -
Investigating the effect of simulated Ischemia on phosphatases : comparing a cardiomyocytes (H9c2) cell line with a breast cancer (MDA-MB 231) cell line
(Stellenbosch : Stellenbosch University, 2020-03)Background: Reversible phosphorylation is responsible for an estimated 30% of protein regulation. Protein phosphorylation is catalysed by protein kinases and dephosphorylation by protein phosphatases. Ischemia, which is ... -
Protein phosphorylation in Ischaemia and reperfusion of the heart : a focus on protein phosphatase 2A
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Understanding the mechanism and signalling pathways involved in myocardial ischaemia/reperfusion (I/R) injury is a prerequisite for elucidating any novel therapeutic intervention to reduce I/R injury. ... -
The effects of a green rooibos extract on the reproductive function of obesity-induced insulin resistant or hypertensive male wistar rats
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Diet-induced obesity (DIO) due to a high caloric diet (HCD) predisposes an individual to the development of diabetes and cardiovascular diseases, with high prevalence in young populations. Existing evidence ... -
Observing the Effects of Anxiety Levels on Male Reproductive Parameters
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Literature presents a complex and often contradictory picture of the link between psychological stress and male fertility. Very limited information is available on the specific relationship between anxiety ... -
The prevalence of type 2 diabetes in South Africa : a systematic review protocol
(BMJ Publishing Group, 2018-06)Introduction Type 2 diabetes mellitus is a major source of morbidity and mortality in South Africa, spurred by increased urbanisation and unhealthy lifestyle factors. Local epidemiological data are required to inform ... -
High fat programming and cardiovascular disease
(MDPI, 2018)ENGLISH ABSTRACT: Programming is triggered through events during critical developmental phases that alter offspring health outcomes. High fat programming is defined as the maintenance on a high fat diet during fetal and/or ... -
Cardiac glucolipotoxicity and cardiovascular outcomes
(MDPI, 2018)Cardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the ... -
Phase 2b controlled trial of M72/AS01E vaccine to prevent tuberculosis
(Massachusetts Medical Society, 2018-10-25)BACKGROUND: A vaccine to interrupt the transmission of tuberculosis is needed. METHODS: We conducted a randomized, double-blind, placebo-controlled, phase 2b trial of the M72/AS01E tuberculosis vaccine in Kenya, South ...
RSS 1.0