Medical Physiology

Investigating the Modulating effects of Fermented Rooibos (Aspalathus linearis) and Fermented Honeybush (Cyclopia intermedia) on aortic endothelial function and antioxidant status in Streptozotocin (STZ) – induced diabetic Wistar rats

Mahlangu, Dawn Nomusa (Stellenbosch : Stellenbosch University, 2020-03)

ENGLISH ABSTRACT: Introduction: Diabetes mellitus is a metabolic disorder that causes chronic hyperglycaemia due to insulin resistance and deficiency. The implications that chronic hyperglycaemia has on vascular function ...

Epacs exchange protein directly activated by cAMP role in obesity-induced cardiovascular diseases

Ndlovu, Zibele (Stellenbosch : Stellenbosch University, 2020-03)

ENGLISH ABSTRACT: Introduction and aims: The strong association between obesity and cardiovascular diseases (CVD) stresses the necessity of elucidating the underlying molecular mechanisms linking these pathologies. ...

HIV/AIDS and air pollution as emerging cardiovascular risk factors in Cape Town populations : is endothelial function a marker of effect

Everson, Frans Pieter (Stellenbosch : Stellenbosch University, 2020-03)

ENGLISH ABSTRACT: Background: HIV and antiretroviral therapy (ART) are associated with cardiovascular disease (CVD). Concomitantly,air pollution is a global health concern and associated with CVD. Although South Africa ...

The Possible Ameliorating effects of Rooibos, Honeybush and Sutherlandia on diabetes-induced reproductive impairment in adult male Wistar rats

Omolaoye, Temidayo Siyanbola (Stellenbosch : Stellenbosch University, 2020-03)

ENGLISH ABSTRACT: The global prevalence of infertility is on the rise, and so is male factor infertility. Out of the approximately 72.4 million infertile couples worldwide, male factor is responsible for 50%. It has ...

Investigating the ameliorative potential of Aspalathus linearis and Cyclopia intermedia against lipid accumulation, lipolysis, oxidative stress and inflammation

Mamushi, Mokadi Peggy (Stellenbosch : Stellenbosch University, 2020-03)

Background Despite the availability of several treatment regimens, obesity continues to be one of the greatest health challenges of the 21st century. In recent years, plant polyphenols have attracted increasing attention ...

Chronic stress and semen parameters

Van der Merwe, Esmari (Stellenbosch : Stellenbosch University, 2020-03)

ENGLISH ABSTRACT: It has been well documented that stress has adverse effects on the body and can lead to various health issues. Stress has been investigated as a cause for unexplained infertility in both men and women. ...

Highly active antiretroviral therapy alters sperm parameters and testicular antioxidant status in diet-induced obese rats

Oyeyipo, Ibukun P.; Skosana, Bongekile T.; Everson, Frans P.; Strijdom, Hans; Du Plessis, Stefan S. (Korean Society of Toxicology, 2018)

The efficacy of highly active antiretroviral therapy (HAART) has led to an increase demand for therapeutic use, thereby necessitating investigation into drug toxicity. This study was designed to investigate the in vivo ...

Investigating the effect of simulated Ischemia on phosphatases : comparing a cardiomyocytes (H9c2) cell line with a breast cancer (MDA-MB 231) cell line

Maumela, Lutendo (Stellenbosch : Stellenbosch University, 2020-03)

Background: Reversible phosphorylation is responsible for an estimated 30% of protein regulation. Protein phosphorylation is catalysed by protein kinases and dephosphorylation by protein phosphatases. Ischemia, which is ...

Protein phosphorylation in Ischaemia and reperfusion of the heart : a focus on protein phosphatase 2A

White, Charlize (Stellenbosch : Stellenbosch University, 2020-03)

ENGLISH ABSTRACT: Understanding the mechanism and signalling pathways involved in myocardial ischaemia/reperfusion (I/R) injury is a prerequisite for elucidating any novel therapeutic intervention to reduce I/R injury. ...

The effects of a green rooibos extract on the reproductive function of obesity-induced insulin resistant or hypertensive male wistar rats

Manirafasha, Claudine (Stellenbosch : Stellenbosch University, 2019-12)

ENGLISH ABSTRACT: Diet-induced obesity (DIO) due to a high caloric diet (HCD) predisposes an individual to the development of diabetes and cardiovascular diseases, with high prevalence in young populations. Existing evidence ...

Observing the Effects of Anxiety Levels on Male Reproductive Parameters

De Jager, Terri-Ann Lenice (Stellenbosch : Stellenbosch University, 2019-12)

ENGLISH ABSTRACT: Literature presents a complex and often contradictory picture of the link between psychological stress and male fertility. Very limited information is available on the specific relationship between anxiety ...

The prevalence of type 2 diabetes in South Africa : a systematic review protocol

Pheiffer, Carmen; Pillay-Van Wyk, Victoria; Joubert, Jane D.; Levitt, Naomi; Nglazi, Mweete D.; Bradshaw, Debbie (BMJ Publishing Group, 2018-06)

Introduction Type 2 diabetes mellitus is a major source of morbidity and mortality in South Africa, spurred by increased urbanisation and unhealthy lifestyle factors. Local epidemiological data are required to inform ...

High fat programming and cardiovascular disease

Cerf, Marlon E. (MDPI, 2018)

ENGLISH ABSTRACT: Programming is triggered through events during critical developmental phases that alter offspring health outcomes. High fat programming is defined as the maintenance on a high fat diet during fetal and/or ...

Cardiac glucolipotoxicity and cardiovascular outcomes

Cerf, Marlon E. (MDPI, 2018)

Cardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the ...

Phase 2b controlled trial of M72/AS01E vaccine to prevent tuberculosis

Van der Meeren, Olivier; Hatherill, Mark; Nduba, Videlis; Wilkinson, Robert J.; Muyoyeta, Monde; Van Brakel, Elana; Ayles, Helen M.; Henostroza, German; Thienemann, Friedrich; Scriba, Thomas J.; Diacon, Andreas; Blatner, Gretta L.; Demoitie, Marie-Ange; Tameris, Michele; Malahleha, Mookho; Innes, James C.; Hellstrom, Elizabeth; Martinson, Neil; Singh, Tina; Akite, Elaine J.; Khatoon Azam, Aisha; Bollaerts, Anne; Ginsberg, Ann M.; Evans, Thomas G.; Gillard, Paul; Tait, Dereck R. (Massachusetts Medical Society, 2018-10-25)

BACKGROUND: A vaccine to interrupt the transmission of tuberculosis is needed. METHODS: We conducted a randomized, double-blind, placebo-controlled, phase 2b trial of the M72/AS01E tuberculosis vaccine in Kenya, South ...