Medical Physiology
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THE EFFECT OF LONG TERM SWIM TRAININ G ON PHYSIOLOGICA L STRESS LEVELS IN THE RAT
(The Society of Medical Laboratory Technologists of South Africa, 2010-12)
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AMP kinase activation and glut4 translocation in isolated cardiomyocytes
(http://www.cvja.co.za/index.php, 2010-03)
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Investigating the effects of first line and second line antiretroviral drugs on HIV exposed endothelial function - A clinical study, supported by a mechanistic in-vitro approach
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Background: There is an interaction between HIV, antiretroviral treatment (ART) and endothelial dysfunction; furthermore, HIV-infected individuals (± ART) show an increased incidence of cardiovascular ...
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Effect of Aspalathus linearis supplementation, during anti-retroviral treatment, on the heart and aortas of male Wistar rats and the effects of drinking rooibos on the cardiovascular profile of patients on ART.
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Introduction Improved survival rates in the human immunodeficiency virus (HIV) population, due to the use of antiretroviral therapy (ART), are associated with increased risk for cardiovascular disease ...
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The role of mitophagy in damage incurred by ischaemia/reperfusion
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Background and aims: Mitophagy is a specialised process of autophagy whereby dysfunctional mitochondria are removed. Mitophagy has been increasingly recognised as an essential process to sustain a healthy ...
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The treatment effect of Rooibos on vascular function and signalling pathways of aortas from diet induced obese rats.
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Introduction: Obesity is becoming a worldwide health problem and is a well-documented independent risk factor for the development of endothelial dysfunction (decreased nitric oxide (NO) bioavailability) ...
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Optimization of experimental conditions and analysis tools for the study of phosphodiesterase-5 in a model of cultured adult rat cardiomyocytes
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Part 1 Introduction: Phosphodiesterases (PDEs) hydrolyse cyclic nucleotides that regulate ischemia-reperfusion injury (IRI) in the heart. Phosphodiesterases-5 (PDE5) inhibition increases cyclic guanosine ...
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Effect of different substrates on functional performance and kinase activation during reperfusion after ischaemia in hearts from obese insulin resistant rats
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Obesity is an important risk factor for the development of insulin resistance, the metabolic syndrome and diabetes and has also been implicated as one of the major risk factors for coronary heart disease. ...
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An investigation into the importance of the ATM protein in the myocardial pathology associated with insulin resistance and type 2 diabetes
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Introduction: Ataxia-telangiectasia (A-T) is an autosomal, recessive disorder that is caused by mutations in the ataxia-telangiectasia mutated (ATM) gene. The gene product, ATM, is a 350 kDa serine/threonine ...
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Rooibos and Melatonin: Putative modulation of nicotine-induced effects on vascular function
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT : Introduction and aims: Cigarette smoking is an important risk factor for cardiovascular disease, and nicotine, the addictive substance in tobacco, is implicated in the pathogenesis of atherosclerosis ...
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Compounds specific to Aspalathus linearis protects the diabetic heart against oxidative stress: a mechanistic study
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT : In diabetics, hyperglycemia, hyperlipidemia and inflammation potentiates the development of cardiovascular diseases (CVDs). These conditions provoke excessive generation of oxidative stress that has been ...
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The dietary ionic effects on sex ratios in animal models
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: X-linked disorders are more expressed in male offspring and prevention of these hereditary diseases is the only recourse to date. Influencing conception towards female offspring can circumvent this problem; ...
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Gamete proteomic profile of male patients suffering from sexually transmitted infections
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: The aim of this study was to provide better insight into the effects of Neisseria gonorrhoea, Chlamydia trachomatis, and Trichomonas vaginalis on semen characteristics. In addition, a crucial focus was ...
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The role of Phosphodiesterase 4 in insulin- and phytocannabinoids-induced cardio-protection, and B-adrenergic cardiac damage.
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH ABSTRACT: Introduction: Cardiovascular disease (CVD) is one of the main non-communicable diseases globally contributing to deaths each year. Ischemic heart disease leading to myocardial infarction (or heart attack ...
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Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity : an in vivo and ex vivo approach
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction: An interaction exists between cardiovascular risk factors (e.g. obesity) and antiretroviral treatment (ART) in the pathogenesis of cardiovascular disease. While ART reverses HIV- related ...
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An investigation into the effects of aspalathin on myocardial glucose transport using cardiomyocytes from control and obesity-induced insulin resistant rats, and terminally differentiated H9C2 cells
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction: Rooibos is an indigenous South African plant ingested as herbal tea and well-known for its strong anti-oxidant effects. Rooibos has shown to have cardioprotective properties in vitro and ...
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The impact of oocyte meiotic spindle and automated zona pellucida score and sperm chromatin packaging on fertilization and pregnancy for assisted reproduction techniques
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Non-invasive selection of developmentally competent human oocytes may provide information on the true fertilization potential of the spermatozoon in the absence of oocyte limitations. The objective was ...
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The role of Atm in the regulation of cardiomyocyte glucose utilization under normal and insulin resistant conditions
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction: Ataxia-telangiectasia (A-T) is an autosomal, recessive disorder that progressively affects multiple organs. A-T is caused by mutations in the Atm gene (ataxia-telangiectasia mutated gene), ...
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Next generation sequencing demonstrates minor variant HIV drug resistance mutations
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction: The South African public sector antiretroviral therapy (ART) roll-out has been associated with emergence of HIV drug resistance (HIVDR) in therapy-naïve and treated patients. These drug-resistant ...
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Mycobactericidal activity of sutezolid (PNU-100480) in sputum (EBA) and blood (WBA) of patients with pulmonary tuberculosis
(PLoS, 2014-04-14)Rationale: Sutezolid (PNU-100480) is a linezolid analog with superior bactericidal activity against Mycobacterium tuberculosis in the hollow fiber, whole blood and mouse models. Like linezolid, it is unaffected by mutations ...
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High resolution imaging study of interactions between the 37 kDa/67 kDa Laminin receptor and APP, beta-secretase and gamma-secretase in Alzheimer’s Disease
(PLoS, 2014-06-27)Alzheimer's disease (AD) is the most prevalent form of dementia affecting the elderly. Neurodegeneration is caused by the amyloid beta (Aβ) peptide which is generated from the sequential proteolytic cleavage of the Amyloid ...
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Effect of melatonin on myocardial susceptibility to ischaemia and reperfusion damage in a rat model of high-fat diet-induced obesity
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: Obesity has reached epidemic proportions worldwide and is currently a serious health problem. It is associated with metabolic abnormalities, oxidative stress, hypertension, insulin resistance and an ...
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The responses of endothelium to insult : does endothelial heterogeneity play a role in in vitro cell models
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: Endothelial injury and dysfunction precede the development of cardiovascular diseases. The endothelium may be regarded as the first line of defence against inflammation / obesity-induced vascular injury, ...
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The role of the beta3-adrenergic receptor (β3-AR) in cardioprotection
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: It is well-established that transient activation of the β-adrenergic signalling pathway with ligands such as isoproterenol, formoterol and dobutamine, elicits cardioprotection against subsequent long ...
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An investigation of the importance of the ATM protein in the endothelium and its role in the signalling pathways of NO production
(Stellenbosch : Stellenbosch University, 2015-04)ENGLISH ABSTRACT: Ataxia telangiectasia (AT) is a well-characterized neurodegenerative disease resulting from a genetic defect in the Atm gene causing an absence or very low expression of the ATM protein. As AT patients ...
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Changes in hyo-laryngeal elevation post-pharyngeal electrical stimulation
(Stellenbosch : Stellenbosch University, 2015-04)ENGLISH ABSTRACT: Swallowing disorders are prevalent in many elderly individuals and are common amongst individuals suffering from neurological diseases. These individuals are affected from slight swallowing difficulty to ...
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Investigating the cholesterol-independent (pleiotropic) effects of selected hypolipidaemic agents in functional and dysfunctional endothelial cells
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH ABSTRACT: Vascular endothelium forms the first line of defence against harmful stimuli in the circulation. Endothelial dysfunction is a valuable predictor of cardiovascular disease and therapies aimed at improving ...
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The effect of Cyclopia maculata extract on β-cell function, protection against oxidative stress and cell survival
(Stellenbosch : Stellenbosch University, 2014-12)ENGLISH ABSTRACT: Insights into the role of oxidative stress and pancreatic β-cell dysfunction in the pathogenesis of type 2 diabetes (T2D) reveals an opportunity for the development of novel therapeutics that directly ...
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Nitric oxide and the endothelium : characterisation of in vitro nitric oxide detection techniques and an ex vivo method of measuring endothelial function
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Introduction: Nitric oxide (NO) is an important chemical messenger in the cardiovascular system. Despite considerable progress in this field, there remains an on-going need for affordable and user-friendly ...
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