Medical Physiology
Collections in this community
Recent Submissions
-
The role of the intestinal immune system in the development and treatment of type 2 diabetes
(Stellenbosch : Stellenbosch University, 2022-11)ENGLISH ABSTRACT: Background: Type 2 diabetes (T2D) is largely correlated with obesity. Low-grade systemic inflammation and altered immune homeostasis in the gut are implicated in the pathogenesis of T2D. The intestinal ... -
The vascular and endothelial effects of HIV, antiretroviral therapy and rooibos - functional effects and mechanism
(Stellenbosch : Stellenbosch University, 2022-12)ENGLISH ABSTRACT: Individuals infected with human immunodeficiency virus-1 (HIV-1) are living longer but are at increased risk of cardiovascular disease (CVD). Antiretroviral therapy (ART) has been implicated in the ... -
Linking LOXL2 to Cardiac Interstitial Fibrosis
(MDPI, 2020-08)Cardiovascular diseases (CVDs) are the leading causes of death worldwide. CVD pathophysiology is often characterized by increased stiffening of the heart muscle due to fibrosis, thus resulting in diminished cardiac function. ... -
Coenzyme Q10 supplementation improves adipokine levels and alleviates inflammation and lipid peroxidation in conditions of metabolic syndrome : a meta-analysis of randomized controlled trials
(MDPI, 2020-05-04)Evidence from randomized controlled trials (RCTs) suggests that coenzyme Q10 (CoQ10) can regulate adipokine levels to impact inflammation and oxidative stress in conditions of metabolic syndrome. Here, prominent electronic ... -
Intimate partner violence: a risk factor for gestational diabetes
(MDPI, 2020-10)The early detection and management of gestational diabetes mellitus (GDM) is an important public health goal. GDM, which is defined as a glucose intolerance that develops during pregnancy, affects about 14% of pregnancies ... -
The beneficial role of Anchomanes difformis in STZ-induced reproductive dysfunction in male Wistar rats
(Dove Press, 2020-11)Background: Progression of diabetes mellitus has increasingly led to several diabetic complications. Diabetes is one of the major factors implicated in male reproductive system damage. Recent approaches such as the use of ... -
In vitro induction of quiescence in isolated primary human myoblasts
(Springer Nature, 2020-01-28)Adult skeletal muscle stem cells, satellite cells, remain in an inactive or quiescent state in vivo under physiological conditions. Progression through the cell cycle, including activation of quiescent cells, is a tightly ... -
DNA methylation of FKBP5 in South African women : associations with obesity and insulin resistance
(BMC, 2020-09)Background: Disruption of the hypothalamic-pituitary-adrenal (HPA) axis, a neuroendocrine system associated with the stress response, has been hypothesized to contribute to obesity development. This may be mediated through ... -
Effect of human immunodeficiency virus on the brain: a review
(American Association for Anatomy, 2020-11)Thirty million people are infected with human immunodeficiency virus (HIV) worldwide, and HIV-associated neurocognitive disorder (HAND) is one of the most common comorbidities of HIV. However, the effect of HIV on the brain ... -
The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling
(Elsevier Masson SAS, 2020-09)Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide, as it affects up to 30 % of adults in Western countries. Moreover, NAFLD is also considered an independent risk factor ... -
Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients
(2020-04)ABSTRACT Antituberculosis (anti-TB) drug development is dependent on informative trials to secure the development of new antibiotics and combination regimens. Clofazimine (CLO) and pyrazinamide (PZA) are important ... -
N-Acetyl Cysteine Targets Hepatic Lipid Accumulation to Curb Oxidative Stress and Inflammation in NAFLD: A Comprehensive Analysis of the Literature
(2020-12-16)Abstract: Impaired adipose tissue function and insulin resistance remain instrumental in promoting hepatic lipid accumulation in conditions of metabolic syndrome. In fact, enhanced lipid accumulation together with oxidative ... -
Is there a combined dose-response effect of cigarette smoking and alcohol use during pregnancy on birth weight in a diverse western cape community of South Africa?
(Stellenbosch : Stellenbosch University, 2022-04)Introduction: Prenatal cigarette exposure (PCE) and prenatal alcohol exposure (PAE) are associated with obstetric complications such as intrauterine growth restriction. This could lead to small for gestational age (SGA) ... -
A mechanistic study on the mu-opioid receptor in human spermatozoa
(Stellenbosch : Stellenbosch University, 2021-12)Background: Infertility remains a complex and often unexplained phenomenon. The effect of opioids on male reproductive parameters is best understood by the suppression of the hypothalamic- pituitary-gonadal (HPG) axis. ... -
Cardio-metabolic risk profile of people living with HIV: Is retinal microvascular geometric morphology a marker of effect?
(Stellenbosch : Stellenbosch University, 2022-04)Background and Aim Cardiovascular disease in people living with HIV has become of great concern. HI-viral factors, ART-toxicity and HIV/ART-associated cardiometabolic adverse effects have been implicated in the development ... -
Factors that affect the adipocytic differentiation of adipose-derived mesenchymal stem cells
(Stellenbosch : Stellenbosch University, 2022-04)Background – Increased adiposity, particularly the accumulation of visceral adipose tissue is linked to the onset and progression of the metabolic syndrome. Despite the known pathogenicity of excessive visceral fat ... -
Physical exercise potentially targets epicardial adipose tissue to reduce cardiovascular disease risk in patients with metabolic diseases : oxidative stress and inflammation emerge as major therapeutic targets
(MDPI, 2021-11-04)ENGLISH ABSTRACT: Excess epicardial adiposity, within a state of obesity and metabolic syndrome, is emerging as an important risk factor for the development of cardiovascular diseases (CVDs). Accordingly, increased epicardial ... -
The effect of an aspalathin-rich rooibos extract on inflammatory crosstalk between adipocytes and muscle cells
(Stellenbosch : Stellenbosch University, 2021, 2021-12)ENGLISH ABSTRACT: The skeletal muscle not only plays a role in maintaining posture and generating force (contraction), but also is a dynamic metabolically active tissue that plays a central role in the regulation of ... -
Molecular basis of the anti‑hyperglycemic activity of RA‑3 in hyperlipidemic and streptozotocin‑induced type 2 diabetes in rats
(BMC (part of Springer Nature), 2019)Background: Insulin resistance is a hallmark of type 2 diabetes mellitus (T2DM) and the underlying cause of various metabolic changes observed in type 2 diabetic patients. This study investigated the molecular basis of ... -
Cellular regenerative therapy for acquired noncongenital musculoskeletal disorders
(South African Medical Association, 2019-08-10)ENGLISH ABSTRACT: Stem cells have an inherent capacity to facilitate regeneration; this has led to unprecedented growth in their experimental use in various clinical settings, particularly in patients with diseases with ...
RSS 1.0