Splenectomy in haematology - A 5-year single centre experience
Date
2005
Authors
Wood L.
Baker P.M.
Martindale A.
Jacobs P.
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Abstract
Objective: To define indications and outcome in haematologic cases undergoing splenectomy. Study design: A retrospective review of clinica l records from consecutive patients having open or laparoscopic removal of the spleen in an academic centre in the private sector. Endpoints were survival, operating time, spleen size, histopathology, requirements for blood or related products complications and average costs. Results: In the total group (n = 69) there were two deaths. Referrals were for immune thrombocytopaenia (41%), acquired haemolytic anaemia (10%), myeloproliferative syndrome (9%), acute or chronic leukaemia (19%), lymphoma (13%) and a miscellaneous group (8%), comprising cholelithiasis, aplasia or as a diagnostic procedure for otherwise unexplained splenomegaly. An open midline approach was predicated by spleens greater than twice normal size and a history of any bleeding disorder. Here the mean operating time was 83-min (range 40-295) whereas for laparoscopy this was 251-min (range 181-272). Summary: Careful stratification between the two options facilitated optimum haemostasis and consequently reduced requirement for packed red cells and platelets. Neither underlying pathology nor the choice of treatment influenced morbidity or mortality. Overall local experience is consistent with published international standards of surgical practice. Outcome is directly proportional to the number of each procedure carried out by a single team, observance of consistent protocols for preoperative evaluation and standardized proactive management through the recovery period. © 2005 Taylor & Francis.
Description
Keywords
azathioprine, cyclophosphamide, immunosuppressive agent, prednisone, vincristine, acquired hemolytic anemia, acute leukemia, adolescent, adult, aged, aplasia, cholelithiasis, chronic leukemia, controlled study, disease association, female, health care cost, human, laparoscopy, major clinical study, male, myeloproliferative disorder, operation duration, plasmapheresis, priority journal, retrospective study, review, splenectomy, statistical analysis, statistical significance, surgical mortality, survival rate, thrombocytopenia, thrombotic thrombocytopenic purpura, Adolescent, Adult, Aged, Aged, 80 and over, Anemia, Hemolytic, Child, Hematologic Diseases, Humans, Leukemia, Myeloid, Chronic, Lymphoma, Male, Middle Aged, Myeloproliferative Disorders, Retrospective Studies, Splenectomy, Splenomegaly, Thrombocytopenia, Treatment Outcome
Citation
Hematology
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6
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6