Efficacy of fibrin sealant in prevention of adhesion formation on ovarian surgical wounds in a rabbit model

Vandendael A. ; Struwig D. ; Nel J.T. ; Kruger T.F. ; Lombard C.J. (1996)


The aim of the study was to determine whether the use of fibrin sealant decreases adhesion formation in ovarian surgical wounds in a rabbit model. A total of 20 female rabbits underwent a midline laparotomy. Microsurgical techniques were used to bivalve each ovary. After randomization one ovary was treated with fibrin sealant, while the other ovary served as a control. Prior to the study project a control group of 15 rabbits was included to study the effect of the laparotomy on the adhesion score of non-bivalved ovaries. At 3 weeks after surgery the adhesion scores were compared using the Wilcoxon signed rank test. The mean adhesion score of the fibrin sealant-treated ovaries (5.20 ± 1.24) was significantly different from the control ovaries (7.35 ± 2.32) (P = 0.0009; confidence intervals 95%). In our study we were able to demonstrate a benefit from using fibrin sealant to decrease postoperative adhesion formation of ovarian surgical wounds in a rabbit model. No influence of the laparotomy on the ovaries was shown. These findings can have applications in endoscopic surgery when procedures are performed on ovaries of human subjects.

Please refer to this item in SUNScholar by using the following persistent URL: http://hdl.handle.net/10019.1/13801
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