Predictive value of abnormal sperm morphology in in vitro fertilization

Kruger T.F. ; Acosta A.A. ; Simmons K.F. ; Swanson R.J. ; Matta J.F. ; Oehninger S. (1988)


In patients with acceptable sperm count and motility, two patterns of abnormal morphology, judged with strict criteria, were identified and described. Patients with < 4% normal forms and < 30% morphology index (summation of normal and slightly amorphous forms) had a fertilization rate of 7.6% of the oocytes (P pattern, poor prognosis). Patients with normal morphology between 4 and 14% had a significantly better fertilization rate of 63.9% of the oocytes (P < 0.0001). Cases with > 14% normal forms fertilized within the normal range for the laboratory. By evaluating sperm morphology with the proposed strict criteria, its predictive value in in vitro fertilization is enhanced.

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