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Immunosuppressive therapy for pemphigus vulgaris complicated by malakoplakia of the bladder

dc.contributor.authorJordaan H.F.
dc.contributor.authorHeyns C.F.
dc.contributor.authorAllen F.J.
dc.contributor.authorSchneider J.
dc.date.accessioned2011-05-15T16:16:04Z
dc.date.available2011-05-15T16:16:04Z
dc.date.issued1990
dc.identifier.citationClinical and Experimental Dermatology
dc.identifier.citation15
dc.identifier.citation6
dc.identifier.issn03076938
dc.identifier.urihttp://hdl.handle.net/10019.1/13620
dc.description.abstractPemphigus vulgaris is an uncommon auto-immune disease which responds well to treatment with corticosteroids and azathioprine. Malakoplakia is a rare granulomatous disease associated with coliform infections and an altered cellular immune response. We report a 68-year-old female patient with pemphigus vulgaris who, after 2 years on maintenance prednisone and azathioprine immunotherapy, developed malakoplakia of the bladder associated with chronic E. coli urinary-tract infection. The malakoplakia responded well to treatment with cotrimoxazole, bethanechol chloride and ascorbic acid, combined with tapering of the corticosteroid dosage. Our patient presents an uncommon but interesting complication of long-term immunosuppressive therapy for pemphigus vulgaris.
dc.subjectascorbic acid
dc.subjectazathioprine
dc.subjectbethanechol
dc.subjectcotrimoxazole
dc.subjectprednisone
dc.subjectaged
dc.subjectarticle
dc.subjectbladder
dc.subjectcase report
dc.subjectfemale
dc.subjecthistology
dc.subjecthuman
dc.subjecthuman cell
dc.subjectmalacoplakia
dc.subjectoral drug administration
dc.subjectpemphigus vulgaris
dc.subjectpriority journal
dc.subjectAged
dc.subjectAzathioprine
dc.subjectBladder Diseases
dc.subjectCase Report
dc.subjectEscherichia coli Infections
dc.subjectFemale
dc.subjectHuman
dc.subjectImmunosuppression
dc.subjectMalacoplakia
dc.subjectPemphigus
dc.subjectPrednisolone
dc.subjectUrinary Tract Infections
dc.titleImmunosuppressive therapy for pemphigus vulgaris complicated by malakoplakia of the bladder
dc.typeArticle
dc.description.versionArticle


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