Human papillomavirus DNA in oral squamous cell carcinomas from an African population sample
Date
1996
Authors
Van Rensburg E.J.
Engelbrecht S.
Van Heerden W.F.P.
Raubennheimer E.J.
Schoub B.D.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background. The incidence of oral squamous cell carcinoma (OSCC) is on the increase in developing countries. Materials and Methods. Formalin fixed paraffin embedded blocks of OSCCs from a Black South African population sample of peri-urban and rural origin were selected as follows: Group 1-57 OSCCs with a mean age of 59 years; Group 2 - 43 OSCCs all cases younger than 40 years; Group 3 - 46 OSCCs with blocks containing only tumour tissue without any normal epithelium and Group 4, a control group of 38 non-neoplastic epithelial lesions. Type specific primers were used in a standard PCR to amplify a segment of the E6 region of HPV 6, 11, 16 and 18. Results. HPV 11 and 16 DNA were found in one sample each from groups 1 and 2 respectively. Conclusion. HPV is not an etiologic factor in the development of OSCC in the population studied.
Description
Keywords
formaldehyde, paraffin, virus dna, adult, aged, article, controlled study, developing country, female, human, human tissue, male, mouth carcinoma, negro, polymerase chain reaction, priority journal, squamous cell carcinoma, wart virus, Adult, African Americans, African Continental Ancestry Group, Base Sequence, Carcinoma, Squamous Cell, DNA, Viral, Female, Humans, Male, Middle Aged, Molecular Sequence Data, Mouth Neoplasms, Papillomaviridae, South Africa
Citation
Anticancer Research
16
2
16
2