Tetrazolyl and tetrazolylidene complexes of gold: A synthetic and structural study

Tetrazolyl and tetrazolylidene complexes of gold: A synthetic and structural study

Gabrielli W.F. ; Nogai S.D. ; McKenzie J.M. ; Cronje S. ; Raubenheimer H.G. ; Gabrielli W.F. ; Nogai S.D. ; McKenzie J.M. ; Cronje S. ; Raubenheimer H.G. (2009)

Article

Article

Lithiation of 1-benzyl-1H-tetrazole followed by transmetallation with [AuCl(PPh3)], [Au(C6F5)(tht)] or [AuCl(tht)] (tht = tetrahydrothiophene) and subsequent alkylation afforded cationic 1-benzyl-4-methyl-4,5-dihydro-1H-1,2,3,4-tetrazol-5-ylidene(triphenylphosphine) gold(i), 1, neutral 1-benzyl-4-methyl-4,5-dihydro-1H-1,2,3,4-tetrazol-5- ylidene(pentafluorophenyl)gold(i), 2, and a cationic biscarbene complex, bis(1-benzyl-4-methyl-4,5-dihydro-1H-1,2,3,4-tetrazol-5-ylidene)gold(i), 3. The first complex underwent a homoleptic rearrangement in solution to form 3. Reaction of [Au(N3)PPh3] with the three isocyanides (CH3)2C6H3NC, tBuNC and CyNC, respectively, yielded the corresponding neutral tetrazolyl(phosphine) complexes of gold, [1-(2,6-dimethylphenyl)-1H-tetrazol-5-yl](triphenylphosphine) gold(i), 4, [1-(tert-butyl)-1H-tetrazol-5-yl](triphenylphosphine)gold(i), 6, and [1-(cyclohexyl)-1H-tetrazol-5-yl](triphenylphosphine)gold(i), 7. Alkylation of 4 with methyl triflate on N4 allowed isolation of the crystalline carbene complex 1-(2,6-dimethylphenyl)-4-methyl-4,5-dihydro-1H-1,2,3,4-tetrazol- 5-ylidene)(triphenylphosphine)gold(i), 5. Complex 7 was not isolable in pure form but converts by isocyanide substitution of triphenylphosphine into [1-cyclohexylisocyanide][1-(cyclohexyl)-1H-tetrazol-5-yl]gold(i), 8. From a product mixture of 7 and 8 the transformed molecules [(cyclohexylamino)(ethoxy) carbene](1-cyclohexyl-1H-tetrazol-5-yl)gold(i), 9, and [bis(cyclohexylamino) carbene](1-cyclohexyltetrazol-5-yl)gold(i), 10, co-crystallised spontaneously after a long time at -20 °C. © 2009 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

Lithiation of 1-benzyl-1H-tetrazole followed by transmetallation with [AuCl(PPh3)], [Au(C6F5)(tht)] or [AuCl(tht)] (tht = tetrahydrothiophene) and subsequent alkylation afforded cationic 1-benzyl-4-methyl-4,5-dihydro-1H-1,2,3,4-tetrazol-5-ylidene(triphenylphosphine) gold(i), 1, neutral 1-benzyl-4-methyl-4,5-dihydro-1H-1,2,3,4-tetrazol-5- ylidene(pentafluorophenyl)gold(i), 2, and a cationic biscarbene complex, bis(1-benzyl-4-methyl-4,5-dihydro-1H-1,2,3,4-tetrazol-5-ylidene)gold(i), 3. The first complex underwent a homoleptic rearrangement in solution to form 3. Reaction of [Au(N3)PPh3] with the three isocyanides (CH3)2C6H3NC, tBuNC and CyNC, respectively, yielded the corresponding neutral tetrazolyl(phosphine) complexes of gold, [1-(2,6-dimethylphenyl)-1H-tetrazol-5-yl](triphenylphosphine) gold(i), 4, [1-(tert-butyl)-1H-tetrazol-5-yl](triphenylphosphine)gold(i), 6, and [1-(cyclohexyl)-1H-tetrazol-5-yl](triphenylphosphine)gold(i), 7. Alkylation of 4 with methyl triflate on N4 allowed isolation of the crystalline carbene complex 1-(2,6-dimethylphenyl)-4-methyl-4,5-dihydro-1H-1,2,3,4-tetrazol- 5-ylidene)(triphenylphosphine)gold(i), 5. Complex 7 was not isolable in pure form but converts by isocyanide substitution of triphenylphosphine into [1-cyclohexylisocyanide][1-(cyclohexyl)-1H-tetrazol-5-yl]gold(i), 8. From a product mixture of 7 and 8 the transformed molecules [(cyclohexylamino)(ethoxy) carbene](1-cyclohexyl-1H-tetrazol-5-yl)gold(i), 9, and [bis(cyclohexylamino) carbene](1-cyclohexyltetrazol-5-yl)gold(i), 10, co-crystallised spontaneously after a long time at -20 °C. © 2009 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

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