Evidence for the binding of the carcinogen 3 methylcholanthrene to both the purine and the pyrimidine bases of hamster fibroblast deoxyribonucleic acid

Jones P.A. ; Gevers W. ; Hawtrey A.O. (1973)


The binding of [3H]3 methylcholanthrene to the DNA of hamster fibroblasts was studied by using chemical methods for DNA degradation. DNA depurinated by mild acid hydrolysis released approximately 1/2 of the radioactivity at the same rate as the purine bases, but the resulting apurinic acid still contained radioactive carcinogen.

Please refer to this item in SUNScholar by using the following persistent URL: http://hdl.handle.net/10019.1/12614
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