Association between clinical and environmental factors and the gut microbiota profiles in young South African children

Files
vanzyl_association_2021.pdf(2.72 MB)
Date
2021
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Research (part of Springer Nature)
Abstract
ENGLISH ABSTRACT: Differences in the microbiota in populations over age and geographical locations complicate cross-study comparisons, and it is therefore essential to describe the baseline or control microbiota in each population. This includes the determination of the influence of demographic, clinical and environmental factors on the microbiota in a setting, and elucidates possible bias introduced by these factors, prior to further investigations. Little is known about the microbiota of children in South Africa after infancy. We provide a detailed description of the gut microbiota profiles of children from urban Cape Town and describe the influences of various clinical and environmental factors in different age groups during the first 5 years of life. Prevotella was the most common genus identified in the participants, and after infancy, the gut bacteria were dominated by Firmicutes and Bacteroidetes. In this setting, children exposed to antibiotics and indoor cooking fires were at the most risk for dysbiosis, showing significant losses in gut bacterial diversity.
Description
CITATION: Nel Van Zyl, K., et al. 2021. Association between clinical and environmental factors and the gut microbiota profiles in young South African children. Scientific Reports, 11:15895, doi:1038/s41598-021-95409-5.
The original publication is available at https://www.nature.com
Publication of this article was funded by the Stellenbosch University Open Access Fund
Keywords
Microbiota, Bacterial diversity, Inflammatory bowel diseases, Microorganisms -- Identification, Bacteriology, Clinical, Health -- Environmental aspects
Citation
Van Zyl, K. N., et al. 2021. Association between clinical and environmental factors and the gut microbiota profiles in young South African children. Scientific Reports, 11:15895, doi:1038/s41598-021-95409-5
URI
http://hdl.handle.net/10019.1/123550
Collections
Research Articles (Medical Microbiology)