Mitogen-activated protein kinase (MAPK) in cardiac tissues
Date
1996
Authors
Page C.
Doubell A.F.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Mitogen-activated protein kinase (MAPK) has recently emerged as a prominent role player in intracellular signalling in the ventricular myocyte with attention being focussed on its possible role in the development of ventricular hypertrophy. It is becoming clear that MAPK is also active in other cells of cardiac origin such as cardiac fibroblasts and possible functions of this signalling pathway in the heart have yet to be explored. In this report the mammalian MAPK pathway is briefly outlined, before reviewing current knowledge of the MAPK pathway in cardiac tissue (ventricular myocytes, vascular smooth muscle cells and cardiac fibroblasts). New data is also presented on the presence and activity of MAPK in two additional cardiac celltypes namely atrial myocytes and vascular endothelial cells from the coronary microcirculation.
Description
Keywords
cell receptor, endothelin 1, heart enzyme, mitogen activated protein kinase, animal cell, article, cell type, endothelium cell, enzyme activation, enzyme activity, enzyme isolation, enzyme localization, fibroblast, heart atrium, heart muscle cell, heart ventricle hypertrophy, microcirculation, muscle cell, newborn, nonhuman, rat, signal transduction, smooth muscle fiber, vascular endothelium, vascular smooth muscle, Amino Acid Sequence, Animals, Ca(2+)-Calmodulin Dependent Protein Kinase, Cardiomegaly, Coronary Circulation, Fibroblasts, Heart, Humans, Mammals, Microcirculation, Models, Cardiovascular, Molecular Sequence Data, Myocardium, Rats, Signal Transduction, Substrate Specificity
Citation
Molecular and Cellular Biochemistry
157
02-Jan
157
02-Jan