Predictors of response to pharmacotherapy with citalopram in obsessive-compulsive disorder
Date
2001
Authors
Stein D.J.
Montgomery S.A.
Kasper S.
Tanghoj P.
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Abstract
Although serotonin reuptake inhibitors (SRIs) are the medications of choice in the treatment of obsessive-compulsive disorder (OCD), only 50-60% of patients respond to a single trial of any of these agents. Improved knowledge of the predictors of response to treatment may have important clinical implications. Data from a large randomized placebo-controlled trial of citalopram in OCD was analysed using logistic regression to determine predictors of response. Demographic (age, sex), clinical (OCD severity and duration, depression severity, prior treatment) and trial variables (citalopram dose, treatment duration) were included. Subjects with longer duration of OCD, more severe OCD symptoms or previous selective SRI use were less likely to be responders in the citalopram trial. In contrast, subjects who received adequate medication doses for sufficient periods of time in the citalopram trial were more likely to be responders. Despite greater awareness of OCD in recent years, there is evidence that the disorder continues to be underdiagnosed and undertreated. The data here emphasize the crucial importance of early diagnosis and treatment of OCD, and of pharmacotherapy with appropriate dose and duration. © 2001 Lippincott Williams & Wilkins.
Description
Keywords
citalopram, serotonin uptake inhibitor, adult, aged, article, controlled study, data analysis, disease course, disease severity, dose response, drug efficacy, drug response, early diagnosis, female, human, major clinical study, male, obsession, prediction, priority journal, regression analysis, treatment planning, Adolescent, Adult, Aged, Citalopram, Double-Blind Method, Female, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Odds Ratio, Predictive Value of Tests, Prognosis, Psychiatric Status Rating Scales, Regression Analysis, Serotonin Uptake Inhibitors
Citation
International Clinical Psychopharmacology
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