Mapping of the variegate porphyria (VP) gene: Contradictory evidence for linkage between VP and microsatellite markers at chromosome 14q32
Date
1996
Authors
Warnich L.
Meissner P.N.
Hift R.J.
Louw J.H.
Van Heerden C.J.
Retief A.E.
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Abstract
The gene for variegate porphyria (VP), an autosomal dominant disease with a high prevalence in South Africa, evidently due to a founder effect, was previously mapped to chromosome 14q32. In the current study this localization was evaluated by linkage and haplotype analyses using microsatellite markers spanning a region of more than 20 cM on chromosome 14q32. In many recent studies linkage disequilibrium between disease and marker loci has been utilized to map genes in founder populations, but we could not find any association between VP and the markers used in this study. Our data suggest that the allocation of VP to chromosome 14q32 may be incorrect.
Description
Keywords
dna marker, satellite dna, article, chromosome 14q, clinical article, gene mapping, genetic linkage, haplotype, human, human cell, porphyria variegata, priority journal, Chromosome Mapping, Chromosomes, Human, Pair 14, DNA, Satellite, Family, Female, Genes, Dominant, Genetic Markers, Genotype, Humans, Linkage (Genetics), Male, Microsatellite Repeats, Porphyrias, Hepatic, Prevalence, South Africa
Citation
Human Genetics
97
5
97
5