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Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease

dc.contributor.authorGuiedem, Eliseen_ZA
dc.contributor.authorPefura-Yone, Eric Walteren_ZA
dc.contributor.authorIkomey, George Mondindeen_ZA
dc.contributor.authorNkenfou, Celine Nguefeuen_ZA
dc.contributor.authorMesembe, Marthaen_ZA
dc.contributor.authorYivala, Mbanyamsig Mispaen_ZA
dc.contributor.authorChendi, Bih Hycentaen_ZA
dc.contributor.authorJacobs, Graeme Brendonen_ZA
dc.contributor.authorChegou, Novel Njweipien_ZA
dc.contributor.authorOkomo, Marie Claire Assoumouen_ZA
dc.date.accessioned2020-10-12T10:42:06Z
dc.date.available2020-10-12T10:42:06Z
dc.date.issued2020-10-01
dc.identifier.citationGuiedem, E., et al. 2020. Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease. BMC Immunology, 21:52, doi:10.1186/s12865-020-00381-w
dc.identifier.issn1471-2172 (online)
dc.identifier.otherdoi:10.1186/s12865-020-00381-w
dc.identifier.urihttp://hdl.handle.net/10019.1/108885
dc.descriptionCITATION: Guiedem, E., et al. 2020. Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease. BMC Immunology, 21:52, doi:10.1186/s12865-020-00381-w.
dc.descriptionThe original publication is available at https://bmcimmunol.biomedcentral.com
dc.description.abstractBackground: Previous studies have shown that tuberculosis (TB) is a risk factor for chronic airflow limitation. Chronic obstructive pulmonary disease (COPD) is recognized as the result of chronic inflammation, usually related to noxious particles. Post-TB airflow obstruction and tobacco-related COPD have the same functional pathway characterized by persistent airflow limitation. We sought to compare the profile of 29 cytokines in the sputum of subjects with post-TB airflow obstruction and those with COPD related to tobacco. Results: The forced expiratory volume in the first second (FEV1) and forced expiratory volume/forced vital capacity (FEV/FVC) ratio were lower in the COPD patients with the history of smoking compared to the post-TB airflow obstruction subgroup. The stages of the disease were more advanced in COPD / tobacco patients. Among the cytokines, IL-1α, IL-1β, MIP-1β, sCD40L and VEGF levels were higher in COPD patients, compared to the controls with p values of 0.003, 0.0001, 0.03, 0.0001 and 0.02 respectively. When the two COPD subgroups were compared, IL-1α, IL-6, TNF-α and IL-8 levels were higher in the COPD patients with the history of tobacco compared to the COPD patients with the history of TB with p-values of 0.031, 0.05, 0.021 and 0.016, respectively. Conclusion: COPD related to tobacco is more severe than post-TB airflow obstruction. The pathogenesis of post-TB airflow obstruction appears to involve the cytokines IL-1RA, IL-1α, IL-1β, IL-17, GRO and sCD40L, while COPD related to tobacco involves more cytokines.
dc.description.urihttps://bmcimmunol.biomedcentral.com/articles/10.1186/s12865-020-00381-w
dc.format.extent11 pages
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Central
dc.subjectBronchial obstruction
dc.titleCytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary diseaseen_ZA
dc.typeArticle
dc.date.updated2020-10-04T05:32:41Z
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyright


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