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Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique

dc.contributor.authorMachado, Adelinaen_ZA
dc.contributor.authorRito, Teresaen_ZA
dc.contributor.authorGhebremichael, Solomonen_ZA
dc.contributor.authorMuhate, Nuelmaen_ZA
dc.contributor.authorMaxhuza, Gabrielen_ZA
dc.contributor.authorMacuamule, Custodiaen_ZA
dc.contributor.authorMoiane, Ivaniaen_ZA
dc.contributor.authorMacucule, Baltazaren_ZA
dc.contributor.authorMarranangumbe, Angelica Suzanaen_ZA
dc.contributor.authorBaptista, Jorgeen_ZA
dc.contributor.authorManguele, Joaquimen_ZA
dc.contributor.authorKoivula, Tuijaen_ZA
dc.contributor.authorStreicher, Elizabeth M.en_ZA
dc.contributor.authorWarren, Robin Marken_ZA
dc.contributor.authorKallenius, Gunillaen_ZA
dc.contributor.authorVan Helden, Paulen_ZA
dc.contributor.authorCorreia-Neves, Margaridaen_ZA
dc.date.accessioned2020-05-15T15:40:13Z
dc.date.available2020-05-15T15:40:13Z
dc.date.issued2018
dc.identifier.citationMachado, A., et al. 2018. Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique. PLOS Neglected Tropical Diseases, 12(1):e0006147, doi:10.1371/journal.pntd.0006147
dc.identifier.issn1935-2735 (online)
dc.identifier.issn1935-2727 (print)
dc.identifier.otherdoi:10.1371/journal.pntd.0006147
dc.identifier.urihttp://hdl.handle.net/10019.1/108561
dc.descriptionCITATION: Machado, A., et al. 2018. Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique. PLOS Neglected Tropical Diseases, 12(1):e0006147, doi:10.1371/journal.pntd.0006147.
dc.descriptionThe original publication is available at https://journals.plos.org/plosntds
dc.description.abstractBovine tuberculosis is a zoonotic disease with largely unknown impact in Africa, with risk factors such as HIV and direct contact with animals or consumption of Mycobacterium bovis infected animal products. In order to understand and quantify this risk and design intervention strategies, good epidemiological studies are needed. Such studies can include molecular typing of M. bovis isolates. The aim of this study was to apply these tools to provide novel information concerning the distribution of bovine tuberculosis in cattle in Mozambique and thereby provide relevant information to guide policy development and strategies to contain the disease in livestock, and reduce the risk associated with transmission to humans. A collection of 178 M. bovis isolates was obtained from cattle in Mozambique. Using spoligotyping and regions of difference analysis, we classified the isolates into clonal complexes, thus reporting the first characterisation of M. bovis strains in this region. Data from MIRU-VNTR typing was used to compare isolates from a number of African countries, revealing a deeply geographically structured diversity of M. bovis. Eastern Africa appears to show high diversity, suggesting deep evolution in that region. The diversity of M. bovis in Africa does not seem to be a function of recent importation of animals, but is probably maintained within each particular region by constant reinfection from reservoir animals. Understanding the transmission routes of M. bovis in Mozambique and elsewhere is essential in order to focus public health and veterinary resources to contain bovine tuberculosis.en_ZA
dc.description.urihttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006147
dc.format.extent17 pages
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Science
dc.subjectBovine tuberculosis -- Mozambiqueen_ZA
dc.subjectTuberculosis in cattle -- Transmissionen_ZA
dc.subjectMycobacterium bovis -- Risk managementen_ZA
dc.subjectTuberculosis bovis -- Epidemiologyen_ZA
dc.subjectMolecular typingen_ZA
dc.subjectMycobacterium bovis -- Geographic distribution -- Mozambiqueen_ZA
dc.titleGenetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambiqueen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyright


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