Distal malignant biliary obstruction : a prospective randomised trial comparing plastic and uncovered self-expanding metal stents in the palliation of symptomatic jaundice
Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Health and Medical Publishing Group
Abstract
Background: The aim of this study was to determine the safety and clinical effectiveness of 10Fr plastic biliary stents
compared to uncovered self-expanding metal stents (SEMS) for palliative treatment of patients with inoperable extra-hepatic
malignant biliary obstruction in a public hospital in South Africa.
Methods: From January 2009 to December 2013, 40 patients who were admitted to a tertiary academic centre because
of distal malignant biliary obstruction were enrolled in a prospective randomized study. Patients were randomly assigned
to receive an uncovered SEMS or a plastic stent deployed through the biliary stricture during endoscopic retrograde
cholangiopancreatography (ERCP).
Results: Patient survival time in the two groups did not differ significantly (median: SEMS – 114 days; plastic – 107 days).
Stent failure was more common in the plastic stent group (7/19 vs. 1/21). The results became significant after 6 months of
follow-up. There was no significant difference between the two groups in the incidence of serious adverse events.
Conclusions: SEMS had a longer duration of patency than plastic stents, which recommends their use in the palliative
treatment of patients with biliary obstruction due to distal malignant biliary obstruction.
Description
CITATION: Bernon, M. M., et al. 2018. Distal malignant biliary obstruction : a prospective randomised trial comparing plastic and uncovered self-expanding metal stents in the palliation of symptomatic jaundice. South African Journal of Surgery, 56(1):30-34, doi:10.17159/2078-5151/2018/v56n1a2208.
The original publication is available at http://www.scielo.org.za
The original publication is available at http://www.scielo.org.za
Keywords
Self-expanding metal stents, Palliative treatment, Jaundice -- Signs, Clinical, Biliary tract -- Cancer
Citation
Bernon, M. M., et al. 2018. Distal malignant biliary obstruction : a prospective randomised trial comparing plastic and uncovered self-expanding metal stents in the palliation of symptomatic jaundice. South African Journal of Surgery, 56(1):30-34, doi:10.17159/2078-5151/2018/v56n1a2208