The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance

Womersley, Jacqueline S. ; Clauss, Lara B. ; Varathan, Olivette ; Engelbrecht, Susan ; Hemmings, Sian M. J. ; Seedat, Soraya ; Spies, Georgina (2019-12-27)

CITATION: Womersley, J. S., et al. 2019. The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance. BMC Research Notes, 12:828, doi:10.1186/s13104-019-4869-9.

The original publication is available at https://bmcresnotes.biomedcentral.com

Article

Objective: Gene–environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were associated with change in cognitive performance. Seventy-three seropositive women completed neuropsychological assessments at baseline and 1-year follow-up. We conducted genetic analyses using DNA obtained from blood and calculated risk scores based on Vpr amino acid 37, 41 and 55 variants that were previously associated with cognitive performance. Results: Global cognitive scores declined significantly over the 1-year study period (p = 0.029). A reduction in global cognitive scores was associated with childhood trauma experience (p = 0.039).

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