Diabetes mellitus and male infertility
Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Medknow
Abstract
ENGLISH ABSTRACT: Infertility is prevalent in about 10%-25% of couples in their reproductive age, analogous to
60-80 million infertile couples globally. Of these infertility cases, 10%-30% are exclusively
attributed to a problem of the male. Several diseases have been implicated as contributors
to deteriorating male fertility and diabetes mellitus (DM) is included. DM, a chronic noncommunicable disease, has been considered as one of the most appreciable health threats,
as it affects 9% (422 million) of the world’s population as of 2014. It is characterised by
hyperglycaemia, which can result from the inability of the pancreatic毬-cells to secrete
insulin or from the target tissue becoming insensitive to insulin. DM has been reported to
influence male reproductive function through diverse pathways and mechanisms. The adverse
effects of reactive oxygen species and successive development of oxidative stress that occur
due to DM have been investigated and implicated by several studies. The products of nonenzymatic glycosylation are reported to be widely distributed in the reproductive tract of
diabetic men. Additionally, DM has been implicated to impair the processes of male sexual
acts. Data reported in this review were extracted from PubMed, Google Scholar, Science
Direct and Scopus with diabetes and male infertility as the key search words. In light of the
aforementioned, the aim of this review is to provide brief background information on DM as
well highlight and explain the likely mechanisms of male fertility which DM impacts.
Description
CITATION: Omolaoye, T. & Du Plessis, S. S. 2018. Diabetes mellitus and male infertility. Asian Pacific Journal of Reproduction, 7(1):6-14, doi:10.4103/2305-0500.220978.
The original publication is available at http://www.apjr.net
The original publication is available at http://www.apjr.net
Keywords
Diabetes mellitus, Male infertility, Diabetic neuropathy, Oxidative stress
Citation
Omolaoye, T. & Du Plessis, S. S. 2018. Diabetes mellitus and male infertility. Asian Pacific Journal of Reproduction, 7(1):6-14, doi:10.4103/2305-0500.220978.