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Safety assessment of antibiotic and probiotic feed additives for Gallus gallus domesticus

dc.contributor.authorNeveling, D. P.en_ZA
dc.contributor.authorVan Emmenes, L.en_ZA
dc.contributor.authorAhire, J. J.en_ZA
dc.contributor.authorPieterse, E.en_ZA
dc.contributor.authorSmith, C.en_ZA
dc.contributor.authorDicks, L. M. T.en_ZA
dc.date.accessioned2018-11-30T10:34:31Z
dc.date.available2018-11-30T10:34:31Z
dc.date.issued2017
dc.identifier.citationNeveling, D. P., et al. 2017. Safety assessment of antibiotic and probiotic feed additives for Gallus gallus domesticus. Scientific Reports, 7:12767, doi:10.1038/s41598-017-12866-7
dc.identifier.issn2045-2322 (online)
dc.identifier.otherdoi:10.1038/s41598-017-12866-7
dc.identifier.urihttp://hdl.handle.net/10019.1/104759
dc.descriptionCITATION: Neveling, D. P., et al. 2017. Safety assessment of antibiotic and probiotic feed additives for Gallus gallus domesticus. Scientific Reports, 7:12767, doi:10.1038/s41598-017-12866-7.
dc.descriptionThe original publication is available at https://www.nature.com
dc.description.abstractAntibiotics in feed select for resistant strains and is thus a threat to human health. In this study, the effect of a multi-strain probiotic and antibiotics on the growth and health of broilers was studied. Equal numbers of broilers received on a daily basis either a multi-strain probiotic or a combination of sulphadiazine, colistin and trimethoprim, whereas the control group received standard feed. The villi of immature broilers (19 days old) administered antibiotics had a larger surface area and their lymphocyte and basophil counts were higher compared to broilers from the probiotic and control groups. The cecal microbiomes of mature broilers (29 days old) that received probiotics had higher levels of Enterobacteriaceae, but lower numbers of Clostridiales, Brucellaceae, Synergistaceae, Erysipelotrichaceae and Coriobacteriaceae compared to the antibiotic-treated group. A decline in the bioluminescence of Listeria monocytogenes observed for broilers on probiotics suggested that the probiotic may be used to control bacterial infections. No significant differences in total red blood cell, haemoglobin and haematocrit content, and mean values for corpuscular volume, corpuscular haemoglobin and corpuscular haemoglobin numbers were recorded amongst broilers from the different treatment groups. This study provides valuable information on the health and performance of broilers when administered probiotics and antibiotics as additives.en_ZA
dc.description.urihttps://www.nature.com/articles/s41598-017-12866-7
dc.format.extent17 pages
dc.language.isoen_ZAen_ZA
dc.publisherNature Research
dc.subjectProbioticsen_ZA
dc.subjectAntibiotics
dc.subjectChickens
dc.subjectBroilers (Chickens)
dc.titleSafety assessment of antibiotic and probiotic feed additives for Gallus gallus domesticusen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyright


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