Quality of pilot trial abstracts in heart failure is suboptimal : a systematic survey
Date
2018-05-31
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central
Abstract
Background: Pilot trials are miniature researches carried out with the sole aim of acting as the precursor for larger
more definitive studies. Abstracts are used to summarize and introduce the findings to the reading audience. There
is substantive empirical evidence showing that abstracts, despite their important roles, are not informative enough,
lacking the necessary details. This systematic survey was designed to assess the quality of reporting of heart failure
pilot trial abstracts. The quality of reporting was defined as the completeness of reporting based on adherence to
the CONSORT extension for reporting of pilot trial abstracts. We also identified factors associated with
reporting quality.
Methods: We searched MEDLINE (PubMed), Cochrane Controlled Trials Register, Scopus, and African-wide
information databases for abstracts from heart failure pilot trials in humans published from 1 January 1990
to 30 November 2016. These were assessed to determine the extent of adherence to CONSORT extension
checklist for reporting of abstracts of pilot trials. We screened identified studies for inclusion based on title and
abstract. Data were independently extracted by two reviewers using the checklist. We used regression analysis to
assess the association between completeness of reporting (measured as the number of items in the CONSORT
extension checklist for reporting of abstracts in pilot trials contained in each abstract) and factors influencing the
quality of the reports.
Results: Two hundred and twenty-eight (228) articles were retrieved, of which 92 met the inclusion criteria. The
mean CONSORT extension score was 8.3/16 (standard deviation 1.7); the least reported items were the source of
funding (1% [1/92]), trial registration (13% [12/92]), randomization sequence (13% [12/92]), number randomized to
each arm (16% [15/92]), and number analyzed in each arm (16% [15/92]). Multivariable regression analysis showed
that pharmacological intervention pilot trials [incidence rate ratio (IRR) = 0.88; 95% confidence interval (CI), 0.81–0.97]
were significantly associated with better reporting. Other factors such as structured abstract (IRR = 1.10; 95% CI,
0.99–1.23) and CONSORT endorsement (IRR = 1.10; 95% CI, 0.99–1.23) only showed minimal relationship with better
reporting quality.
Conclusion: The quality of reporting of abstracts of heart failure pilot trials was suboptimal. Pharmacological
intervention was significantly associated with better reporting. These findings are consistent with previous
research on reporting of trials.
Description
CITATION: Isiguzo, G. C., et al. 2018. Quality of pilot trial abstracts in heart failure is suboptimal : a systematic survey. Pilot and Feasibility Studies, 4:107, doi:10.1186/s40814-018-0302-8.
The original publication is available at https://pilotfeasibilitystudies.biomedcentral.com
The original publication is available at https://pilotfeasibilitystudies.biomedcentral.com
Keywords
Heart failure
Citation
Isiguzo, G. C., et al. 2018. Quality of pilot trial abstracts in heart failure is suboptimal : a systematic survey. Pilot and Feasibility Studies, 4:107, doi:10.1186/s40814-018-0302-8