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The effect of salsola tuberculatiformis bostchantzev on the androgen and glucocorticoid receptors in prostate cancer cell lines

dc.contributor.advisorSwart, P.en_ZA
dc.contributor.advisorSwart, Amanda C.en_ZA
dc.contributor.authorKelbe, Lisa Suzanneen_ZA
dc.contributor.otherStellenbosch University. Faculty of Science. Dept. of Biochemistry.en_ZA
dc.date.accessioned2017-05-23T10:10:04Z
dc.date.accessioned2017-12-11T10:38:53Z
dc.date.available2017-05-23T10:10:04Z
dc.date.available2017-12-11T10:38:53Z
dc.date.issued2017-12
dc.identifier.urihttp://hdl.handle.net/10019.1/102666
dc.descriptionThesis (MSc)--Stellenbosch University, 2017.en_ZA
dc.description.abstractENGLISH ABSTRACT: This study describes: 1. The preparation of a biologically active methanol extract from S.tuberculatiformis. 2. The demonstration of biological activity for both the crude S.tuberculatiformis extract and Compound A. 3. The effects of the crude S.tuberculatiformis extract and Compound A on nuclear translocation of the androgen and estrogens receptors in three different prostate cancer cell-lines. 4. Cell viability assays demonstrating the potency (IC50) for Compound A and the crude S.tuberculatiformis extract between the three prostate cancer cell-lines. 5. Caspase assays to demonstrate apoptosis for the crude S.tuberculatiformis extract and Compound A in prostate cancer celllines.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Hierdie studie beskryf: 1. Die bereiding van 'n biologies-aktiewe kru metanolekstrak uit S.tuberculatiformis. 2. Die bepaling van die biologiese aktiwiteit vir beide die kru metanolekstrak uit S.tuberculatiformis en verbinding A. 3. Die effek van die kru S.tuberculatiformis ekstrak en verbindingA op die translokasie van die glukokortikoïed- en androgeenreseptore in drie verskillende prostaatkanker sel-lyne. 4. Sellewensvatbaarheidstoetse (IC50) met drie prostaatkankersellyne om die toksisiteit van die kru metanolekstrak uit S.tuberculatiformis en verbinding A te bepaal. 5. Kaspasetoetse in prostaatkanker sel-lyne om die apoptotiese effek van die kru metanolekstrak uit S.tuberculatiformis en verbinding A te demonstreer.af_ZA
dc.format.extent178 pages : illustrationsen_ZA
dc.language.isoen_ZAen_ZA
dc.publisherStellenbosch : Stellenbosch Universityen_ZA
dc.subjectProstate canceren_ZA
dc.subjectAndrogen receptor -- Effect of salsola tuberculatiformis bostchantzev onen_ZA
dc.subjectGlucocorticoid receptor -- Effect of salsola tuberculatiformis bostchantzev onen_ZA
dc.subjectUCTDen_ZA
dc.titleThe effect of salsola tuberculatiformis bostchantzev on the androgen and glucocorticoid receptors in prostate cancer cell linesen_ZA
dc.typeThesisen_ZA
dc.rights.holderStellenbosch Universityen_ZA


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