Association between tuberculosis and a polymorphic NFκB binding site in the interferon γ gene
Date
2003
Authors
Rossouw M.
Nel H.J.
Cooke G.S.
Van Helden P.D.
Hoal E.G.
Journal Title
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Volume Title
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Abstract
Interferon γ is believed to be crucial for host defence against many infections. To test the hypothesis that a polymorphism in the gene for interferon γ (IFNG) is associated with susceptibility to tuberculosis, we did two independent investigations. In a case-control study of 313 tuberculosis cases, we noted a significant association between a polymorphism (+874A→T) in IFNG and tuberculosis in a South African population (p=0.0055). This finding was replicated in a family-based study, in which the transmission disequilibrium test was used in 131 families (p=0.005). The transcription factor NFκB binds preferentially to the +874T allele, which is over-represented in controls. This preferential binding suggests that genetically determined variability in interferon γ and expression might be important for the development of tuberculosis.
Description
Keywords
DNA, gamma interferon, immunoglobulin enhancer binding protein, transcription factor, allele, article, binding affinity, binding site, case control study, controlled study, disease course, DNA polymorphism, family study, gene expression, genetic analysis, genetic association, genetic susceptibility, genetic variability, human, infection sensitivity, major clinical study, population research, priority journal, South Africa, tuberculosis, Alleles, Case-Control Studies, Genetic Predisposition to Disease, Humans, Interferon-alpha, NF-kappa B, Polymorphism, Single Nucleotide, South Africa, Tuberculosis
Citation
Lancet
361
9372
361
9372