Use of spoligotyping for accurate classification of recurrent tuberculosis

Warren R.M. ; Streicher E.M. ; Charalambous S. ; Churchyard G. ; Van der Spuy G.D. ; Grant A.D. ; Van Helden P.D. ; Victor T.C. (2002)


The spoligotyping method has become an important tool for the tracking of Mycobacterium tuberculosis strains in different epidemiological settings. In this study, we demonstrate the ability of the spoligotyping technique to accurately determine the pathogenetic mechanism of recurrent disease. This methodology has advantages over conventional restriction fragment length polymorphism methods which may be useful in large-scale intervention studies.

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