IS6110-Mediated Deletion Polymorphism in Isogenic Strains of Mycobacterium tuberculosis
Date
2004
Authors
Sampson S.L.
Richardson M.
Van Helden P.D.
Warren R.M.
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Abstract
Previous studies have described IS6110-mediated polymorphism as an important driving force in Mycobacterium tuberculosis genome evolution and have provided indirect evidence for IS6110-driven deletion events. This study provides the first description of an IS6110-mediated deletion event in truly isogenic strains. We also provide further support for the hypothesis that the region from Rv1754 to Rv1765 is a hot spot for IS6110 insertion and deletion events.
Description
Keywords
article, bacterial genome, DNA polymorphism, gene deletion, gene insertion sequence, Mycobacterium tuberculosis, nonhuman, priority journal, sequence analysis, Southern blotting, Chromosomes, Bacterial, DNA Transposable Elements, Evolution, Molecular, Genome, Bacterial, Mycobacterium tuberculosis, Phylogeny, Polymerase Chain Reaction, Polymorphism, Genetic, Sequence Deletion, Actinobacteria (class), Bacteria (microorganisms), insertion sequences, Mycobacterium, Mycobacterium tuberculosis, Prokaryota, uncultured actinomycete, unidentified insertion sequence
Citation
Journal of Clinical Microbiology
42
2
42
2