Dihydropteroate synthase and novel dihydrofolate reductase gene mutations in strains of Pneumocystis jirovecii from South Africa
Date
2005
Authors
Robberts F.J.L.
Chalkley L.J.
Weyer K.
Goussard P.
Liebowitz L.D.
Journal Title
Journal ISSN
Volume Title
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Abstract
Dihydropteroate synthase (DHPS) gene mutations have raised concerns about emerging sulfonamide resistance in Pneumocystis jirovecii. DHPS and dihydrofolate reductase (DHFR) gene products were amplified in clinical specimens from South African patients. One of 53 DHPS genes sequenced contained the double mutation Thr55Ala Pro57Ser. DHFR gene mutations detected were Ala67Val and the new mutations Arg59Gly and C278T. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Description
Keywords
alanine, arginine, cotrimoxazole, dihydrofolate reductase, dihydropteroate synthase, gene product, glycine, sulfonamide, antibiotic resistance, article, bacterium identification, fungal gene, fungal strain, fungus mutation, gene amplification, gene mutation, gene sequence, human, nonhuman, nucleotide sequence, Pneumocystis jiroveci, Pneumocystis pneumonia, prevalence, priority journal, South Africa, Dihydropteroate Synthase, Humans, Mutation, Pneumocystis, Tetrahydrofolate Dehydrogenase, Pneumocystis jirovecii
Citation
Journal of Clinical Microbiology
43
3
43
3