The effect of methylprednisolone, given prior to cardiopulmonary bypass, on indices of gas exchange
This study examined the effect of a single dose of methyl-prednisolone ((MP) 30 mg/kg) given before cardiopulnionary bypass (CPB) on the alveolar/arterial oxygen gradient (AaDO2) and arterial oxygen tension/inspired oxygen fraction quotient (PaO2/FiO2) at 1, 24 and 48 hours after CPB. The study was prospective and patients were randomly allocated to one of two groups. Of the 295 patients entered into the study, 165 received MP and 130 did not. The mortality rate in the MP group was 4.24% and in the control group the mortality rate was 3.85% (P = 0.894). No difference in the postoperative PaO2/FiO2 and AaDO2 could be demonstrated when patients who had received MP were compared with those who had not received MP pre-operatively.