Browsing by Author "Van Buuren, A. J."
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- ItemLow plasma pyridoxal-5'-phosphate levels in children with the nephrotic syndrome(Health & Medical Publishing Group, 1985) Van Buuren, A. J.; Shephard, G. S.; Labadarios, D.Of 35 children with the nephrotic syndrome in relapse, 88% were found to have low circulating plasma pyridoxal-5'-phosphate (PLP) levels. Remission of the syndrome was associated with spontaneous normalization of plasma PLP levels in 23 such children. A significant (P < 0.001) positive correlation (r = 0.81) was found between plasma albumin and PLP levels and a significant (P < 0.001) negative correlation (r = -0.66) between plasma PLP and serum cholesterol levels. The low plasma PLP levels may be due to enhanced urinary excretion of albumin-bound PLP in view of the severe proteinuria which characterizes the nephrotic syndrome.