Browsing by Author "Tsakalakos, N."
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- ItemAcetylated fetal haemoglobin in neonates born to mothers with established and gestational diabetes(Health and Medical Publishing Group (HMPG), 1985-10) MacFarlane, C. M.; Tsakalakos, N.; Taljaard, J. J. F.Birth weight ratios (BWRs) and cord blood C-peptide values were significantly higher in neonates born to mothers with well-controlled gestational diabetes (GD) than in those born to mothers with well-controlled established diabetes (ED) or mothers with normal results on glucose tolerance testing. The neonates born to the ED mothers had the highest cord blood acetylated fetal haemoglobin (Hb F1) values, and these values correlated with cord C-peptide values. The cord C-peptide values in the GD group correlated with BWRs, but not with Hb F1 values. These results suggest differential tissue utilization of glucose in neonates born to mothers with different types of diabetes.
- ItemNeonatal pancreatic function in infants born to mothers with gestational and overt diabetes(Health and Medical Publishing Group -- HMPG, 1984-11) De Villiers, T. J.; MacFarlane, C. M.; Tsakalakos, N.; Taljaard, J. J. F.Neonatal pancreatic function was assessed in infants born to non-diabetic mothers and to mothers with well-controlled gestational diabetes (GD) and overt diabetes (OD) using cord blood C-peptide estimations and the calculation of cord C-peptide/glucose ratios. Exaggerated pancreatic function was present in infants born to mothers with GD. In these infants the increased cord C-peptide values and cord C-peptide/glucose ratios correlated with their increased birth weight ratios. These results could not be explained on the basis of maternal hyperglycaemia and a possible intrinsic difference in pancreatic response between infants born to mothers with GD and those born to mothers with OD is suggested.
- ItemValue of acetylated haemoglobin assay in fetal assessment(Health & Medical Publishing Group, 1987-5) Macfarlane, C. M.; Tsakalakos, N.; Taljaard, J. J. F.Acetylation of fetal haemoglobin, probably a posttranslational, intracellular, enzyme-mediated reaction, depends upon an adequate supply of glucose and oxygen to the fetus and the nature of the diabetes (if present) in the mother. These complicating factors limit the general usefulness of acetylated fetal haemoglobin assay in fetal assessment.