Browsing by Author "Munoz, Jose F."

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    50 years of Emmonsia disease in humans : the dramatic emergence of a cluster of novel fungal pathogens
    (Public Library of Science, 2015) Schwartz, Ilan S.; Kenyon, Chris; Feng, Peiying; Govender, Nelesh P.; Dukik, Karolina; Sigler, Lynne; Jiang, Yanping; Stielow, J. Benjamin; Munoz, Jose F.; Cuomo, Christina A.; Botha, Alfred; Stchigel, Alberto M.; De Hoog, G. Sybren
    New species of Emmonsia-like fungi, with phylogenetic and clinical similarities to Blastomyces and Histoplasma, have emerged as causes of systemic human mycoses worldwide. They differ from classical Emmonsia species by producing a thermally-dependent, yeast-like phase rather than adiaspores, and by causing disseminated infections, predominantly in immunocompromised patients and often with high case-fatality rates. Such differences will be important for clinicians to consider in diagnosis and patient management, and for microbiologists who may encounter these fungi with increasing frequency.
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    Emergomyces : the global rise of new dimorphic fungal pathogens
    (Public Library of Science, 2019) Schwartz, Ilan S.; Govender, Nelesh P.; Sigler, Lynne; Jiang, Yanping; Maphang, Tsidiso G.; Toplis, Barbra; Botha, Alfred; Dukik, Karolina; Hoving, J. Claire; Munoz, Jose F.; De Hoog, Sybren; Cuomo, Christina A.; Colebunders, Robert; Kenyon, Chris
    Unknown until recently, the genus Emergomyces is composed of dimorphic fungi with human pathogenic potential. Five described species have been implicated as causes of disease in immunocompromised persons on at least 4 continents. In some regions, such as southern Africa, this disease, emergomycosis, is now the most commonly diagnosed dimorphic fungal infection. Herein, we review the history of these fungi, clinical features and pathogenesis of disease, what is known of their biology, and future research directions.