Effect of selective noradrenergic denervation on noradrenaline content and [3H]dopamine release in rat nucleus accumbens slices

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dc.contributor.authorRussell V.A.
dc.contributor.authorLamm M.C.L.
dc.contributor.authorAllin R.
dc.contributor.authorDe Villiers A.S.
dc.contributor.authorSearson A.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:28Z
dc.date.available2011-05-15T16:17:28Z
dc.date.issued1989
dc.description.abstractDSP4 (N-(2-chloroetyl)-N-ethyl-2-bromobenzylamine) treatment (50 mg/kg i.p., 10 days previously) significantly decreased the noradrenaline (NA) content of the rostral part of the nucleus accumbens. The medial and caudal areas were not affected. The nucleus accumbens appears to receive noradrenergic innervation predominantly from subcoeruleus nuclei of the pons-medulla while the locus coeruleus neurons project to the rostral area. The isoproterenol-induced enhancement of the K+-evoked release of [3H]dopamine (DA) was not affected by DSP4 treatment. Noradrenergic denervation does not appear to have been sufficient to cause up-regulation of postsynaptic β-adrenoceptors.
dc.description.versionArticle
dc.identifier.citationNeurochemical Research
dc.identifier.citation14
dc.identifier.citation2
dc.identifier.issn03643190
dc.identifier.urihttp://hdl.handle.net/10019.1/14229
dc.subjectamphetamine
dc.subjectisoprenaline
dc.subjectnomifensine
dc.subjectradioisotope
dc.subjectanimal cell
dc.subjectdopamine release
dc.subjectmale
dc.subjectnonhuman
dc.subjectnoradrenergic system
dc.subjectnucleus accumbens
dc.subjectpriority journal
dc.subjectrat
dc.subjectAnimal
dc.subjectBenzylamines
dc.subjectBiogenic Amines
dc.subjectBrain
dc.subjectDopamine
dc.subjectIn Vitro
dc.subjectMale
dc.subjectNeurotoxins
dc.subjectNorepinephrine
dc.subjectNucleus Accumbens
dc.subjectOrgan Specificity
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectReference Values
dc.subjectSeptal Nuclei
dc.subjectSupport, Non-U.S. Gov't
dc.titleEffect of selective noradrenergic denervation on noradrenaline content and [3H]dopamine release in rat nucleus accumbens slices
dc.typeArticle
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