Old dogmas and new hearts: A role for adult stem cells in cardiac repair?

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dc.contributor.authorNiesler C.U.
dc.date.accessioned2011-05-15T15:56:43Z
dc.date.available2011-05-15T15:56:43Z
dc.date.issued2004
dc.description.abstractThe vast developmental repertoire of embryonic stem cells is well recognised. These primitive stem cells can differentiate in vivo and in vitro into cells of all three embryonic germ layers (endoderm, mesoderm, ectoderm), making them attractive potential agents to target for enhanced tissue repair and regeneration. Adult stem cells on the other hand are considered more restricted in their lineage differentiation capabilities. Recent research has challenged this dogma with the finding that bone marrow-derived stem cells can differentiate into a wide variety of cell types including muscle (skeletal and cardiac). Furthermore, although the myocardium has for decades been regarded as a post-mitotic organ, a series of studies has indicated that a population of stem cells exists which is capable of at least partial reconstitution of the myocardium following an ischaemic insult. It is therefore now accepted that adult stem cells could be used to enhance myocardial repair. This review discusses the current status of adult stem cell research in the light of its potential for improving myocardial repair.
dc.description.versionConference Paper
dc.identifier.citationCardiovascular Journal of South Africa
dc.identifier.citation15
dc.identifier.citation4
dc.identifier.issn10159657
dc.identifier.urihttp://hdl.handle.net/10019.1/9999
dc.subjectcell differentiation
dc.subjectcell lineage
dc.subjectcell type
dc.subjectconference paper
dc.subjectectoderm
dc.subjectendoderm
dc.subjectheart muscle ischemia
dc.subjecthematopoietic stem cell
dc.subjectmesoderm
dc.subjectstem cell
dc.subjecttissue regeneration
dc.subjecttissue repair
dc.subjectAdult
dc.subjectAnimals
dc.subjectCell Differentiation
dc.subjectCell Movement
dc.subjectChemotaxis
dc.subjectClinical Trials
dc.subjectHumans
dc.subjectMyocardial Ischemia
dc.subjectMyocytes, Cardiac
dc.subjectStem Cell Transplantation
dc.subjectStem Cells
dc.titleOld dogmas and new hearts: A role for adult stem cells in cardiac repair?
dc.typeConference Paper
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