Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A meta-analysis of randomized controlled treatment trials
Date
2006
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Abstract
Small studies have shown positive effects from adding a variety of antipsychotic agents in patients with obsessive-compulsive disorder who are unresponsive to treatment with serotonin reuptake inhibitors. The evidence, however, is contradictory. This paper reports a meta-analysis of existing double-blind randomized placebo-controlled studies looking at the addition of the second-generation antipsychotic quetiapine in such cases. Three studies fulfilled the inclusion criteria. Altogether 102 individuals were subjected to analysis using Review Manager (4.2.7). The results showed evidence of efficacy for adjunctive quetiapine (<400 mg/day) on the primary efficacy criterion, measured as changes from baseline in total Yale-Brown Obsessive Compulsive Scale scores (P=0.008), the clinical significance of which was limited by between-study heterogeneity. The mechanism underlying the effect may involve serotonin and/or dopamine neurotransmission. © 2006 Lippincott Williams & Wilkins, Inc.
Description
Keywords
placebo, quetiapine, serotonin uptake inhibitor, adult, article, clinical trial, controlled clinical trial, controlled study, double blind procedure, drug efficacy, drug resistance, female, human, major clinical study, male, Obsessive-compulsive disorder, priority journal, randomized controlled trial, scoring system, treatment outcome, Adult, Antipsychotic Agents, Dibenzothiazepines, Drug Therapy, Combination, Female, Humans, Male, Obsessive-compulsive disorder, Psychiatric Status Rating Scales, Randomized Controlled Trials, Serotonin Uptake Inhibitors, Treatment Outcome
Citation
International Clinical Psychopharmacology
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