Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries

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dc.contributor.authorOcklenburg, Sebastianen_ZA
dc.contributor.authorSchmitz, Judithen_ZA
dc.contributor.authorMoinfar, Zahraen_ZA
dc.contributor.authorMoser, Dirken_ZA
dc.contributor.authorKlose, Renaen_ZA
dc.contributor.authorLor, Stephanieen_ZA
dc.contributor.authorKunz, Georgen_ZA
dc.contributor.authorTegenthoff, Martinen_ZA
dc.contributor.authorFaustmann, Pedroen_ZA
dc.contributor.authorFrancks, Clydeen_ZA
dc.contributor.authorEpplen, Jorg T.en_ZA
dc.contributor.authorKumsta, Roberten_ZA
dc.contributor.authorGunturkun, Onuren_ZA
dc.date.accessioned2018-08-21T09:08:38Z
dc.date.available2018-08-21T09:08:38Z
dc.date.issued2017
dc.descriptionCITATION: Ocklenburg, S., et al. 2017. Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries. eLife, 6:e22784, doi:10.7554/eLife.22784.
dc.descriptionThe original publication is available at https://elifesciences.org
dc.description.abstractLateralization is a fundamental principle of nervous system organization but its molecular determinants are mostly unknown. In humans, asymmetric gene expression in the fetal cortex has been suggested as the molecular basis of handedness. However, human fetuses already show considerable asymmetries in arm movements before the motor cortex is functionally linked to the spinal cord, making it more likely that spinal gene expression asymmetries form the molecular basis of handedness. We analyzed genome-wide mRNA expression and DNA methylation in cervical and anterior thoracal spinal cord segments of five human fetuses and show development-dependent gene expression asymmetries. These gene expression asymmetries were epigenetically regulated by miRNA expression asymmetries in the TGF-β signaling pathway and lateralized methylation of CpG islands. Our findings suggest that molecular mechanisms for epigenetic regulation within the spinal cord constitute the starting point for handedness, implying a fundamental shift in our understanding of the ontogenesis of hemispheric asymmetries in humans.en_ZA
dc.description.urihttps://elifesciences.org/articles/22784
dc.description.versionPublisher's version
dc.format.extent19 pages
dc.identifier.citationOcklenburg, S., et al. 2017. Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries. eLife, 6:e22784, doi:10.7554/eLife.22784
dc.identifier.issn2050-084X (online)
dc.identifier.otherdoi:10.7554/eLife.22784
dc.identifier.urihttp://hdl.handle.net/10019.1/104315
dc.language.isoen_ZAen_ZA
dc.publishereLife Sciences Publications
dc.rights.holderAuthors retain copyright
dc.subjectSpine -- Genetic aspectsen_ZA
dc.subjectCerebral dominanceen_ZA
dc.subjectLaterality -- Genetic aspectsen_ZA
dc.subjectLeft- and right-handedness -- Epigeneticsen_ZA
dc.titleEpigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetriesen_ZA
dc.typeArticleen_ZA
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