Maternal risk factors predicting child physical characteristics and dysmorphology in fetal alcohol syndrome and partial fetal alcohol syndrome

Simple item page
dc.contributor.authorMay P.A.
dc.contributor.authorTabachnick B.G.
dc.contributor.authorGossage J.P.
dc.contributor.authorKalberg W.O.
dc.contributor.authorMarais A.-S.
dc.contributor.authorRobinson L.K.
dc.contributor.authorManning M.
dc.contributor.authorBuckley D.
dc.contributor.authorHoyme H.E.
dc.date.accessioned2011-10-13T16:59:02Z
dc.date.available2011-10-13T16:59:02Z
dc.date.issued2011-10-13
dc.description.abstractBackground: Previous research in South Africa revealed very high rates of fetal alcohol syndrome (FAS), of 46-89 per 1000 among young children. Maternal and child data from studies in this community summarize the multiple predictors of FAS and partial fetal alcohol syndrome (PFAS). Method: Sequential regression was employed to examine influences on child physical characteristics and dysmorphology from four categories of maternal traits: physical, demographic, childbearing, and drinking. Then, a structural equation model (SEM) was constructed to predict influences on child physical characteristics. Results: Individual sequential regressions revealed that maternal drinking measures were the most powerful predictors of a child's physical anomalies (R2 = .30, p < .001), followed by maternal demographics (R2 = .24, p < .001), maternal physical characteristics (R2 = .15, p < .001), and childbearing variables (R2 = .06, p < .001). The SEM utilized both individual variables and the four composite categories of maternal traits to predict a set of child physical characteristics, including a total dysmorphology score. As predicted, drinking behavior is a relatively strong predictor of child physical characteristics (β = 0.61, p < .001), even when all other maternal risk variables are included; higher levels of drinking predict child physical anomalies. Conclusions: Overall, the SEM model explains 62% of the variance in child physical anomalies. As expected, drinking variables explain the most variance. But this highly controlled estimation of multiple effects also reveals a significant contribution played by maternal demographics and, to a lesser degree, maternal physical and childbearing variables. © 2011.
dc.description.versionArticle in Press
dc.identifier.citationDrug and Alcohol Dependence
dc.identifier.citationhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79957880200&partnerID=40&md5=8259b632080a370d90c9ef9e3800d8fd
dc.identifier.issn3768716
dc.identifier.other10.1016/j.drugalcdep.2011.05.009
dc.identifier.urihttp://hdl.handle.net/10019.1/16957
dc.subjectDysmorphology
dc.subjectFetal alcohol spectrum disorders (FASD)
dc.subjectFetal alcohol syndrome (FAS)
dc.subjectHuman malformations
dc.subjectMaternal risk factors
dc.subjectPartial fetal alcohol syndrome (PFAS)
dc.titleMaternal risk factors predicting child physical characteristics and dysmorphology in fetal alcohol syndrome and partial fetal alcohol syndrome
dc.typeArticle in Press
Files
Collections
Stellenbosch University - Scopus Publications