The pharmacokinetics of oral indoramin during pregnancy

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dc.contributor.authorSchabort I.
dc.contributor.authorOdendaal H.J.
dc.contributor.authorPierce D.M.
dc.date.accessioned2011-05-15T16:15:46Z
dc.date.available2011-05-15T16:15:46Z
dc.date.issued1990
dc.description.abstractThe pharmacokinetics of indoramin (Baratol; Wyeth) and its active metabolite 6-hydroxyindoramin administered to 13 women as a single 37.5 mg dose of indoramin were compared under pregnant and post-partum conditions. No significant differences were observed between values determined under pregnant and post-partum conditions, for any pharmacokinetic parameter. C(max) and AUC values in individual subjects differed, in most cases, by no more than two-fold, i.e. the same order of magnitude as intra-subject variation seen in volunteers dosed repeatedly with indoramin. Median values of C(max), AUC(0,24) and t( 1/2 ,z) were of a similar order to values seen previously in normal volunteers after a single 37.5 mg dose. It is concluded that in treating hypertension associated with pregnancy, this study does not provide evidence to depart from the usual clinical practice of titrating indoramin dosage with control of blood pressure as the end-point, keeping in mind the restriction of the dose-limiting side-effect of sedation.
dc.description.versionArticle
dc.identifier.citationBritish Journal of Clinical Pharmacology
dc.identifier.citation29
dc.identifier.citation4
dc.identifier.issn03065251
dc.identifier.urihttp://hdl.handle.net/10019.1/13482
dc.subjectindoramin
dc.subjectadult
dc.subjectarticle
dc.subjectclinical article
dc.subjectdrug absorption
dc.subjectdrug blood level
dc.subjectfemale
dc.subjecthuman
dc.subjecthypertension
dc.subjectoral drug administration
dc.subjectpharmacokinetics
dc.subjectpreeclampsia
dc.subjectpregnancy
dc.subjectpriority journal
dc.subjectAdult
dc.subjectFemale
dc.subjectHalf-Life
dc.subjectHuman
dc.subjectIndoles
dc.subjectIndoramin
dc.subjectIntestinal Absorption
dc.subjectPregnancy
dc.subjectSupport, Non-U.S. Gov't
dc.titleThe pharmacokinetics of oral indoramin during pregnancy
dc.typeArticle
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