Distribution of acetylator genotypes in the coloured population of the Western Cape region of South Africa

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dc.contributor.authorParkin D.P.
dc.contributor.authorVandenplas M.
dc.contributor.authorDonald P.R.
dc.contributor.authorVandenplas S.
dc.contributor.authorBotha F.J.H.
dc.contributor.authorSeifart H.I.
dc.contributor.authorVan Jaarsveld P.P.
dc.contributor.authorVan Helden P.
dc.date.accessioned2011-05-15T15:55:21Z
dc.date.available2011-05-15T15:55:21Z
dc.date.issued1998
dc.description.abstractRecent advances in molecular biology techniques for polymorphic N-acetyltransferase (NAT2) enzyme characterisation, involving polymerase chain reaction (PCR) multiplication and restriction enzyme cleavage of DNA, were used to determine the distribution of acetylator genotypes and their constituent alleles in the coloured population of the Western Cape region of South Africa. The frequency of slow acetylator individuals in the trial population was q2 = 0.286, indicating a frequency of slow acetylator alleles of q = 0.535. The trial population could be shown to be in Hardy-Weinberg equilibrium in accordance with a trimodal pattern of distribution of acetylator genotypes.
dc.description.versionArticle
dc.identifier.citationSouth African Journal of Science
dc.identifier.citation94
dc.identifier.citation8
dc.identifier.issn382353
dc.identifier.urihttp://hdl.handle.net/10019.1/9725
dc.subjectacetylation
dc.subjectacyltransferase
dc.subjectallele
dc.subjectDNA analysis
dc.subjectenzyme analysis
dc.subjectenzyme characterization
dc.subjectgenotype
dc.subjectpolymerase chain reaction
dc.subjectrestriction enzyme analysis
dc.subjectSouth Africa
dc.titleDistribution of acetylator genotypes in the coloured population of the Western Cape region of South Africa
dc.typeArticle
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