Clinical significance of the low normal sperm morphology value as proposed in the fifth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen

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dc.contributor.authorMenkveld R.
dc.date.accessioned2011-05-15T16:15:39Z
dc.date.available2011-05-15T16:15:39Z
dc.date.issued2010
dc.description.abstractThe very low cut-off value for sperm morphology of 4% morphologically normal spermatozoa, as proposed in the new edition of the World Health Organization (WHO) manual on semen analysis, is in agreement with recently published values and reflects the trend of a decline in reported mean values for normal sperm morphology. The reduced value for morphologically normal spermatozoa over the years may be due to several factors. The first is the introduction of strict criteria for the evaluation of sperm morphology. Other reasons may include the introduction of additional criteria for sperm morphology abnormalities and the suggested decrease in semen parameters because of increasing negative environmental influences. Although on its own the newly proposed very low normal value may not provide the strong predictive value for a males' fertility potential, as originally reported for sperm morphology evaluated according to strict criteria, a good predictive value can still be obtained if the holistic, strict approach for sperm morphology evaluation is followed together with additional sperm morphology parameters now available, because certain morphology patterns and sperm abnormalities are now known to be of strong prognostic value. In addition, better international standardization of the technical methodology, consensus on the interpretation of sperm morphology evaluation criteria and standardized international external quality control (EQC) schemes, are of utmost importance to maintain the good predictive value of sperm morphology. © 2010 AJA, SIMM & SJTU.
dc.description.versionReview
dc.identifier.citationAsian Journal of Andrology
dc.identifier.citation12
dc.identifier.citation1
dc.identifier.issn1008682X
dc.identifier.other10.1038/aja.2009.14
dc.identifier.urihttp://hdl.handle.net/10019.1/13432
dc.subjectsalazosulfapyridine
dc.subjectacrosome
dc.subjectcell elongation
dc.subjectcytoplasm
dc.subjectdrug substitution
dc.subjectdrug use
dc.subjectdrug withdrawal
dc.subjectenvironmental factor
dc.subjectglobozoospermia
dc.subjecthuman
dc.subjectlarge head spermatozoa
dc.subjectleukocyte count
dc.subjectmale fertility
dc.subjectmegalo head spermatozoa
dc.subjectmethodology
dc.subjectmorphology
dc.subjectprognosis
dc.subjectquality control
dc.subjectresidue analysis
dc.subjectreview
dc.subjectsemen abnormality
dc.subjectsemen analysis
dc.subjectshort tail syndrome
dc.subjectsmall head spermatozoa
dc.subjectsperm
dc.subjectspermatozoon
dc.subjectulcerative colitis
dc.subjectworld health organization
dc.subjectHumans
dc.subjectInfertility, Male
dc.subjectMale
dc.subjectManuals as Topic
dc.subjectPrognosis
dc.subjectReference Values
dc.subjectSemen Analysis
dc.subjectSpermatozoa
dc.subjectWorld Health Organization
dc.titleClinical significance of the low normal sperm morphology value as proposed in the fifth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen
dc.typeReview
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